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Table 2 Patient Clinical and Quality-of-Life Measurements (Total N = 120)

From: Comparison of health-related quality of life measures in chronic obstructive pulmonary disease

Measure
mean (SD)
Total Sample
(n = 120)
GOLD
Stage 1
(n = 23)
GOLD
Stage 2
(n = 53)
GOLD
Stage 3
(n = 27)
GOLD
Stage 4
(n = 17)
ANOVA   ANOVA KWT
       F-stat RE p-value p-value
FEV1 (%) 58.4 (24.8) 92.9 (13.7) 65.5 (9.1) 37.4 (5.7) 23.0 (4.8) 254.2   <0.001 <0.001
6MWT (m) 312.5 (108.0) 356.7 (124.3) 321.0 (95.8) 315.0 (98.8) 222.5 (89.6) 6.01   <0.001 <0.001
Borg Dyspnea 2.48 (1.64) 1.19 (1.11) 2.33 (1.65) 3.48 (1.67) 3.12 (0.49) 11.55   <0.001 <0.001
SGRQ Total 41.3 (19.7) 28.8 (15.0) 37.2 (18.6) 52.2 (19.6) 54.1 (13.5) 11.15 Ref <0.001 <0.001
SGRQ Symptom 50.0 (24.1) 42.4 (21.4) 46.8 (23.9) 60.1 (26.1) 54.4 (20.2) 2.98 0.27 0.03 0.02
SGRQ Activity 57.3 (27.6) 38.0 (23.8) 53.5 (28.1) 65.7 (23.0) 82.5 (10.0) 12.36 1.11 <0.001 <0.001
SGRQ Impact 29.9 (18.9) 19.4 (14.9) 25.8 (16.3) 41.9 (20.0) 37.8 (17.5) 9.34 0.84 <0.001 <0.001
SF-36 PCS 34.4 (9.6) 39.5 (10.1) 34.4 (10.7) 32.4 (7.8) 30.9 (4.2) 3.49 0.31 0.02 0.002
SF-36 MCS 49.6 (10.9) 52.60 (9.4) 50.5 (10.4) 47.9 (12.5) 45.5 (10.7) 1.75 0.16 0.16 0.114
EQ-5D US Index 0.73 (0.19) 0.80 (0.13) 0.70 (0.21) 0.72 (0.19) 0.72 (0.16) 1.35 0.11 0.26 0.079
EQ-5D UK Index 0.63 (0.27) 0.73 (0.19) 0.59 (0.32) 0.63 (0.25) 0.63 (0.24) 1.38 0.12 0.25 0.069
EQ-5D VAS 65.3 (18.9) 74.3 (16.3) 66.2 (20.0) 60.1 (18.4) 58.7 (15.8) 3.31 0.30 0.02 0.004
  1. GOLD: global burden of obstructive lung disease; Ref: Reference; RE: Relative efficiency ratio; SGRQ: St. George's Respiratory Questionnaire; ref: reference; ANOVA: analysis of variance; KWT: Kruskal-Wallis test