# Table 3 Model characteristics and differences between the four groups, after adjusting for age, gender, VI, number of comorbidities other than CVCs, duration of PXE and help needed to fill in questionnaires (analysis of covariance).

Adjusted mean/RC* 95% CI Significance of the model/change* Partial Eta2 +
Corrected model Groups A-D as a predictor within the model
Functional IVI    p < 0.001 0.812 + 0.241 +
Group A (reference) 23.66 (20.92; 26.40)
Group B -1.89 (-4.91; 1.13) 0.216
Group C -5.60 (-9.19; -2.01) 0.003
Group D -6.90 (-10.41; -3.39) < 0.001
Emotional IVI    p < 0.001 0.662 + 0.128 +
Group A (reference) 7.47 (5.97; 8.97)
Group B -0.33 (-1.88; 1.22) 0.777
Group C 1.94 (0.06; 3.82) 0.043
Group D 1.32 (-0.66; 3.31) 0.188
Rasch guided SF-36 Physical Functioning    p = 0.086 0.187+ 0.064+
Group A (reference) 21.50 (15.51; 27.49)
Group B -2.34 (-8.66; 3.97) 0.461
Group C -6.03 (-13.49; 1.45) 0.111
Group D -0.81 (-8.70; 7.09) 0.839
Rasch guided SF-36 Mental Health    p = 0.093 0.159+ 0.044+
Group A (reference) 16.28 (12.06; 20.50)
Group B -3.77 (-8.41; 0.87) 0.109
Group C -0.19 (-5.87; 5.49) 0.947
Group D -2.28 (-7.64; 3.09) 0.400
1. Presented are fully adjusted models including interactions between all variables.
2. Functional and emotional subscale scores of both the IVI and SF-36 contributed reciprocally and were also adjusted for.
3. RC = regression coefficient, *reported for the model/change of mean in groups compared to group A (reference); CI = Confidence interval; Group A = No impairment; Group B = Only CVCs; Group C = Only VI; Group D = CVCs & VI; Bolded values indicate statistical significance; + Partial Eta2 effect size: ≥0.01 small, ≥0.06 medium, ≥0.14 large effect[53]