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Table 3 Magnitude and direction of response shift for the entire sample

From: Minimal important differences and response shift in health-related quality of life; a longitudinal study in patients with multiple myeloma

EORTC QLQ-C30 domain

N

n

Response shift

95% CI for response shift

p-value

ES

Pain

235

 

4.8

 

< 0.01

0.16

    improved

 

58

-2.9

-11, 5

0.49

-0.09

    unchanged

 

127

6.4

3, 10

< 0.01

0.23

    deteriorated

 

50

9.7

3, 17

< 0.01

0.35

Fatigue

236

 

6.2

 

< 0.01

0.25

    improved

 

56

-0.4

-6, 5

0.82

-0.02

    unchanged

 

121

6.2

3, 9

< 0.01

0.25

    deteriorated

 

59

12.4

7, 18

< 0.01

0.49

Physical function

230

 

-1.5

 

0.10

-0.07

    improved

 

74

2.9

0, 6

0.09

0.13

    unchanged

 

98

-1.4

-4, 1

0.22

-0.06

    deteriorated

 

58

-7.4

-12, -3

< 0.01

-0.33

Quality of life

238

 

2.7

 

< 0.01

0.11

    improved

 

79

7.1

3, 12

< 0.01

0.27

    unchanged

 

110

0.8

-2, 4

0.55

0.04

    deteriorated

 

49

-0.2

-5, 4

0.86

-0.01

  1. CI: Confidence interval
  2. ES: Effect size (mean score change/SDpretest)
  3. Response shift: Pre-test - Then-test