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Table 3 HRQoL of children with SCD aged 6-11 compared to age matched healthy siblings and Dutch norm population of the KIDSCREEN-52

From: Double disadvantage: a case control study on health-related quality of life in children with sickle cell disease

Ā 

Children with SCD

(n = 17)

Healthy siblings

(n = 19)

SCD versus healthy siblings

Norm population

(n = 641)

SCD versus norm population

Ā 

Mean

SD

Mean

SD

Effect size

Mean

SD

Point estimate of mean difference (95% CI)

Physical Well-being

51 *

9.5

58

11.7

0.7

57

9.5

-6 (-11; +1)

Psychological Well-being

55

8.7

57

9.1

0.2

56

9.1

-1 (-5; +3)

Moods & Emotions

46 *

11.0

48

12.3

0.2

53

9.5

-7 (-12; -2)

Self-Perception

50 *

7.9

54

11.0

0.4

57

9.8

-7 (-12; -2)

Autonomy

49 *

6.8

50 *

9.4

0.1

57

8.6

-8 (-12; -4)

Parent Relation

48 *

10.4

50 *

10.1

0.2

56

8.4

-8 (-12; -4)

Financial Resources

44 *

11.8

43 *

14.2

0.1

51

10.6

-7 (-12; -2)

Social Support & Peers

53

11.7

49

13.9

0.3

53

9.1

0 (-4; +4)

School Environment

56

8.1

57

11.2

0.1

58

10.2

-2 (-7; +3)

Bullying

42 *

10.9

46

12.6

0.3

48

11.0

-6 (-11; +1)

  1. Higher scores represent better HRQoL.
  2. *p < 0.05 children with SCD and/or healthy siblings versus Dutch norm population of the KIDSCREEN-52.