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Table 4 Multiple linear regression on HRQOL scores*

From: Health-related quality of life of Southern Chinese with chronic hepatitis B infection

 

SF-6D

SF36v2-PCS

SF36v2-MCS

CLDQ-Overall

 

Coefficient (95% CI)

Coefficient (95% CI)

Coefficient (95% CI)

Coefficient (95% CI)

Stage of illness (vs. uncomplicated CHB)

    

Impaired LF

-0.04† (-0.116, 0.034)

-3.80 (-9.083, 1.476)

-1.14 (-7.194, 4.914)

-0.44† (-0.94, 0.065)

Cirrhosis

-0.08†‡ (-0.143, 0.015)

-5.36‡ (-9.856, 0.869)

-2.59 (-7.742, 2.563)

-0.68†‡ (-1.106, 0.251)

HCC

-0.10†‡ (-0.16, -0.03)

-5.62‡ (-10.196, -1.045)

-3.70 (-8.944, 1.548)

-0.73†‡ (-1.161, -0.29)

Have taken treatment (vs. no treatment)

-0.04†‡ (-0.079, -0.003)

-1.84 (-4.536, 0.86)

-3.62†‡ (-6.71, -0.523)

-0.26†‡ (-0.516, -0.003)

Clinical

    

Bilirubin (umol/L, 10-2)

-0.05 (-0.107, 0.008)

-7.38†‡ (-11.429, -3.337)

-4.33 (-8.968, 0.31)

-0.42†‡ (-0.807, -0.037)

Co-morbidity

    

Psychological illness, present (vs. absent)

-0.10†‡ (-0.193, -0.015)

-4.36 (-10.643, 1.932)

-12.78†‡ (-19.993, -5.574)

-0.67†‡ (-1.272, -0.075)

Socio-demographic

    

Smoking status (vs. never smoker)

    

Former smoker

-0.06†‡ (-0.109, -0.017)

-3.24 (-6.491, 0.016)

-4.52†‡ (-8.248, -0.788)

-0.24 (-0.548, 0.071)

Current smoker

0.01† (-0.058, 0.074)

-3.21 (-7.854, 1.43)

4.46† (-0.862, 9.782)

0.23 (-0.212, 0.671)

Age (years, 10-1)

0.04†‡ (0.015, 0.056)

0.80 (-0.642, 2.239)

1.88†‡ (0.229, 3.532)

0.15†‡ (0.012, 0.286)

Sex, female (vs. male)

-0.07†‡ (-0.126, -0.015)

-5.73†‡ (-9.609, -1.859)

-2.08 (-6.528, 2.359)

-0.30 (-0.671, 0.066)

Occupation, others (vs. professional and administrative)

0.01 (-0.034, 0.057)

-3.45†‡ (-6.644, -0.259)

0.56 (-3.097, 4.225)

-0.14 (-0.443, 0.164)

Household income (vs. >30000)

    

<10000

-0.07‡ (-0.127, -0.006)

-3.74 (-7.992, 0.503)

-3.90 (-8.766, 0.974)

-0.14 (-0.544, 0.264)

10000–19999

-0.03 (-0.095, 0.031)

0.40 (-4.038, 4.833)

-2.21 (-7.3, 2.872)

0.08 (-0.344, 0.5)

20000–29999

-0.01 (-0.076, 0.061)

-0.20 (-5.014, 4.621)

0.25 (-5.273, 5.774)

0.11 (-0.347, 0.569)

Constant

0.70 (0.582, 0.824)

52.63 (44.11, 61.146)

45.88 (36.118, 55.652)

5.63 (4.824, 6.444)

R-square

0.23

0.29

0.24

0.25

  1. PCS = Physical Component Summary Score; MCS = Mental Component Summary Score; CHB = Chronic Hepatitis B; LF = Liver Function; HCC = Hepatocellular Carcinoma. Notes:
  2. *Stage of illness, treatment, clinical, co-morbidities, and socio-demographic variables were entered as independent variables. Biomarkers (ALT, AST and bilirubin), duration of illness and age were treated as continuous variables; all other variables were entered as categorical variables. Sex, education attainment, marital status, occupation, taking anti-viral treatment, co-morbidity, and family history of HB/CLD and biomarker (AFP) were coded as dichotomous variables: female vs. male; primary or below vs. other educational levels; other marital status vs. married; other occupation vs. administrative, managerial and professionals, presence vs. absence of a diagnosis, abnormal vs. normal.
  3. † Significant in overall model (p < 0.05).
  4. ‡ Significant difference compared with reference group which indicates in bracket, except for bilirubin and age (p < 0.05).
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