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Table 8 Studies on relationship between quality of life data and survival in patients with other cancers

From: Quality of life data as prognostic indicators of survival in cancer patients: an overview of the literature from 1982 to 2008

Author(s) Year Sample HRQOL measure(s) Results*
Andrykowski et al. [92] 1994 42 leukemia Depressed mood + Functional QOL + MAC Anxious preoccupation and functional QOL were independent predictors of survival.
Tannock et al. [93] 1996 161 symptomatic hormone-resistant prostate EORTC QLQ-C30 + QLQ-PR25 + PROSQOLI Appetite loss, pain, and physical functioning were associated with survival.
Wisloff and Hjorth [94] 1997 468 multiple myeloma EORTC QLQ-C30 Physical functioning was independent prognostic factor of survival.
Meyers et al. [95] 2000 80 brain (recurrent glioblastoma multiforme or anaplastic astrocytoma) FACT-Br + ADL Measures of QOL and ADL were not independently related to survival.
Jerkeman et al. [96] 2001 95 aggressive lymphoma EORTC QLQ-C30 Pretreatment global QOL was an independent prognostic marker of overall survival.
Roychowdury et al. [97] 2003 364 locally advanced and metastatic bladder EORTC QLQ-C30 Longer survival was associated with high physical functioning, low role functioning and no anorexia.
Sehlen et al. [98] 2003 153 brain tumors FACT-G The FACT-G sum score was a significant predictor of survival.
Collette et al. [99] 2004 391 symptomatic metastatic hormone-resistant prostate cancer EORTC QLQ-C30 Insomnia and appetite loss were significant independent predictors of survival.
Monk et al. [100] 2005 179 advanced cancer of cervix FACT-G + Cervix subscale + FACT/GOG-Ntx+ BPI Baseline FACT-Cx (FACT-G + Cervix subscale) scores was associated with survival.
Brown et al. [101] 2005 273 brain (high grade gloima) LASA scales (to measure overall QOL)+ FACT-Br + Fatigue (SDS) + Sleep (ESS) + depression (POMS-SF)+ Mental health (MMSE) Changes in QOL measures over time were not found to be associated with survival.
Brown et al. [102] 2006 194 brain (high grade glioma) LASA scales (to measure overall QOL)+ FACT-Br + Fatigue (SDS) + Sleep (ESS) + depression (POMS-SF) + Mental health (MMSE) Fatigue was significant independent predictor of survival.
Yeo et al. [103] 2006 233 unresectable hepatocellular EORTC QLQ-C30 Appetite loss, physical and role functioning scores were significant predictor of survival.
Lis et al. [104] 2006 55 pancreatic cancer Ferrans and Powers QLI Health and physical subscale was marginally significant predictor of survival.
Dubois et al. [105] 2006 202 refractory multiple myeloma EORTC QLQ-C30 + QLQ-MY24 + FACIT-F + FACT/GOG-Ntx Fatigue was significant predictor of survival.
Sullivan et al. [106] 2006 809 metastatic hormon-refractory prostate EORTC QLQ-C30 + FACT-P Baseline QOL scores (global QOL, physical, role, and social functioning and pain, fatigue and appetite loss) were significant predictors of survival.
Mauer et al. [107] 2007 247 brain (anaplastic oligodenroglimas) EORTC QLQ-C30 + EORTC QLQ-BN20 Emotional functioning, communication deficit, future uncertainty, and weakness of legs were significant prognostic of survival. Baseline QOL scores added little to clinical factors to predict survival.
Mauer et al. [108] 2007 490 brain (new diagnosed glioblastoma) EORTC QLQ-C30 + QLQ-BN20 Cognitive functioning, global health status, and social functioning were significant prognostic factors of survival. Baseline QOL scores added little to clinical factors to predict survival.
Fielding and Wong [44] 2007 358 liver and lung FACT-G Global QOL scores did not predict survival in liver and lung cancer. Physical well-being and appetite predicted survival in lung cancer.
Viala et al. [109] 2007 202 multiple myeloma EORTC QLQ-C30, EORTC QLQ-MY24, FACIT-F, FACT/GOG-Ntx 14 out of 21 patient-reported outcomes were significant predictors of mortality. Clinical plus PRO data increased the predictive power.
Bonnetain et al. [110] 2008 538 advanced hepatocellular carcinoma Spitzer QLI Baseline QOL was independent prognostic factor for survival.
Carey et al. [111] 2008 244 advanced ovarian cancer EORTC QLQ-C30 Performance status and global QOL scores at baseline were prognostic factors for both progression-free survival and overall survival.
Gupta et al. [112] 2008 90 ovarian cancer Ferrans and Powers QLI No statistically significant prognostic association of patient satisfaction with QOL was observed with survival.
Robinson et al. [113] 2008 86 pancreatic cancer FACIT-F+ FAACT + BPI + SF-36 Fatigue strongly predicted survival.
Strasser-Weippl and Ludwig [114] 2008 92 multiple myeloma EORTC QLQ-C30 Role, emotional, cognitive and social functioning but not physical functioning and global QOL were found to be independent prognostic factors of overall survival.
  1. Abbreviations: ADL: Activities of Daily Living; BPI: Brief Pain Inventory; EORTC QLQ-C30: European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire; EORTC QLQ-BN20: EORTC Brain Cancer specific Quality of Life Questionnaire; EORTC QLQ-MY24: EORTC Myeloma specific Quality of Life Questionnaire; EORTC QLQ-PR25: EORTC Prostate Cancer specific Quality of Life Questionnaire; ESS: Epworth Sleepiness Scale; FACIT-F: Functional Assessment of Chronic Illness Therapy-Fatigue scale; FACT-Br: Functional Assessment of Cancer Therapy-Brain module; FACT-G: Functional Assessment of Cancer Therapy-General module; FACT-P: Functional Assessment of Chronic Illness Therapy-Prostate module; FAACT: Functional Assessment of Anorexia/Cachexia Therapy; FACT/GOG-Ntx: FACT Gynecologic Oncology Group Neurotoxicity scale; LASA: Linear Analog Self Assessment; MAC: Mental Adjustment to Cancer Scale; MMSE: Folstein Mini-Mental State Examination; POMS-SF: Profile of Mood State-Short Form; PRO: patient-reported outcomes; PROSQOL: Prostate Cancer-Specific Quality-of-Life Instrument; QLI: Quality of Life Index; QOL: quality of life; SDS: Symptom Distress Scale; SF-36: 36-item Short Form Health Survey
  2. * All results obtained from multivariate analyses after controlling for one or more demographic and known biomedical prognostic factors.