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Table 6 Studies on relationship between quality of life data and survival in patients with head and neck cancer

From: Quality of life data as prognostic indicators of survival in cancer patients: an overview of the literature from 1982 to 2008

Author(s) Year Sample HRQOL measure(s) Results*
De Boer [77] 1998 133 head and neck Self-reported psychosocial and physical functioning Patients with higher perceived physical abilities were likely to survive more and less likely to develop a recurrence.
de Graeff et al. [78] 2001 208 head and neck EORTC QLQ-C30 + QLQ-H&N35 + CES-D Cognitive functioning was predictor of survival while physical functioning; mood and global QOL were not.
Fang et al. [79] 2004 102 advanced head and neck EORTC QLQ-C30 + EORTC QLQ-H&N35 Baseline fatigue was predictive of survival while changes in QOL scores during treatment was not.
Mehanna and Morton [80] 2006 200 head and neck AQLQ + LSS + GHQ QOL at diagnosis was not significant predictor of survival. One year after diagnosis poor life satisfaction score and pain were significant predictors of survival.
Nordgren et al. [81] 2006 89 head and neck EORTC QLQ-C30 Physical functioning was significant predictor of survival.
Coyne et al. [82] 2007 1093 locally advanced head and neck cancer Emotional well-being (FACT-G) Emotional functioning was not an independent predictor of survival.
Siddiqui et al. [83] 2008 1093 locally advanced head and neck cancer FACT-H&N The FACT-H&N score was independently predictive of loco-regional control but not overall survival.
Karvonen-Gutierrez et al. [84] 2008 495 head and neck cancer SF-36, HNQOL The SF-36 physical component summary score and three domains of the HNQOL (pain, eating and speech) were associated with survival.
  1. Abbreviations: AQLQ: Auckland Quality of Life Questionnaire; CES-D: Centre for Epidemiologic Studies-Depression Scale; EORTC QLQ-C30: European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire; EORTC QLQ-H&N35: EORTC Head and Neck Cancer specific Quality of Life Questionnaire; FACT-G: Functional Assessment of Cancer Therapy-General module; FACT-H&N: Functional Assessment of Cancer Therapy-Head & Neck module; HNQOL: Head and Neck Quality of Life Questionnaire; GHQ: General Health Questionnaire; LSS: Life Satisfaction Score; QOL: quality of life; SF-36: 36-item Short Form Health Survey
  2. * All results obtained from multivariate analyses after controlling for one or more demographic and known biomedical prognostic factors.