Estimation of minimally important differences in EQ-5D utility and VAS scores in cancer

Table 5 MID estimates for EQ-5D VAS scores by ECOG grade and FACT-G quintile

Cancer Group	Quintile FACT	FACT mean	n	Mean	SD	Median	Mean Diff	SEM	0.5 SD	0.33 SD
All	1	56.7	102	52	18	50	11	10	9	6
	2	68.9	107	63	18	70	8	10	9	6
	3	76.9	111	71	18	70	5	10	9	6
	4	83.7	101	76	16	80	3	9	8	5
	5	92.7	107	78	19	80		11	9	6
Mean MID							7	10	9	6
Lung	1	56.7	7	45	19	50	16	11	9	6
	2	68.9	11	61	18	60	21	10	9	6
	3	76.9	6	82	7	85	-7	4	4	2
	4	83.7	10	75	18	75	0	10	9	6
	5	92.7	16	75	24	80		14	12	8
Mean MID							7	10	9	6
	ECOG Grade
All	0		122	77	19	80	8	11	10	6
	1		258	69	18	70	8	10	9	6
	2		133	61	20	60	3	11	10	7
	3		21	57	23	50		13	12	8
Mean MID							8	11	10	6
Lung	0		9	80	11	80	9	6	5	4
	1		29	71	16	75	17	9	8	5
	2		11	54	17	69	24	10	9	6
	3		1	30		30
Mean MID							12	9	8	5

ECOG – Eastern Cancer Oncology Group (grade ranges from level 0 is fully active to level 3, capable of only limited self-care and confined to bed more than 50% of waking hours); MID – minimally important difference; SEM – standard error of the mean; SD – standard deviation

ISSN: 1477-7525