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Table 4 Changes in utility measures at 2 yrs by presence or absence of Serious Adverse Event episodes

From: Which health-related quality of life score? A comparison of alternative utility measures in patients with Type 2 diabetes in the ADVANCE trial

Serious Adverse Event episodes (in 2-year period)   Dolan Shaw Brazier SF6D (SF12) Brazier SF6D (SF36) Lundberg Lawrence Franks MEPS Franks Fryback
NO Mean difference* -.024 -.017 -.019 -.019 -.021 -.023 -.022 -.018 -.013
  Std. Deviation .196 .139 .115 .121 .078 .142 .146 .146 .068
YES Mean difference* -.042 -.028 -.035 -.031 -.037 -.046 -.052 -.058 -.015
  Std. Deviation .230 .157 .127 .125 .087 .156 .173 .190 .068
Regression coeff** (P value) -.040 (.003) -.028 (.003) -.033 (<.001) -.032 (<.001) -.024 (<.001) -.046 (<.001) -.053 (<.001) -.062 (<.001) -.017 (<.001)
Signal/Noise ratio .090 .082 .136 .104 .202 .161 .205 .277 .037
  1. Note1: * Mean difference is the mean of the difference between the two-year and baseline values for each utility measure.
  2. Note2: ** Regression model assessed significance of Serious Adverse Event episodes on difference in 2 yr score, adjusted for baseline score.