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Table 5 Predictors of Mental health MSQoL-54 scales by IFN-β treatment (Multivariate hierarchical analysis)

From: Influence of Interferon beta treatment on quality of life in multiple sclerosis patients

  Emotional well being Role limitation emotional Health distress Cognitive function Overall quality of life
Effect β p β p β p β p β p
Intercept* 73.6 <.0001 53.68 <.0001 69.6 <.0001 78.3 <.0001 68.6 <.0001
Age at inclusion -0.31 0.32 -0.11 0.45 0.08 0.57 -0.41 0.01 0.02 0.86
Gender (Male vs. Female) -19.83 0.003 1.68 0.57 -3.69 0.19 -8.55 0.01 -4.05 0.14
Disease duration -0.29 0.49 0.13 0.50 0.08 0.69 -0.16 0.49 0.13 0.49
Disease course (SP vs. RR) 15.2 0.15 8.75 0.08 4.21 0.37 14.8 0.008 -2.55 0.57
Relapse rate 2-yrs before study entry -0.31 0.97 0.15 0.96 -0.31 0.92 -0.40 0.92 -1.40 0.66
EDSS 1.15 0.71 -2.13 0.14 -0.11 0.93 -0.70 0.67 -1.51 0.25
BDI -1.50 <.0007 -1.86 <.0001 -1.75 <.0001 -1.01 <.0001 -1.35 <.0001
FSS -8.33 <.0005 1.67 0.12 -2.86 0.005 -1.06 0.38 0.02 0.98
MMSE-c 0.15 0.91 0.42 0.44 0.84 0.11 1.69 0.009 0.39 0.46
IFN-β treatment (Yes vs No) 7.67 0.34 5.22 0.13 4.99 0.13 3.12 0.44 -1.16 0.73
Relapse rate change after 2-yrs -4.36 0.57 3.64 0.39 -1.90 0.72 2.90 0.51 -3.34 0.35
EDSS change after 2-yrs 2.95 0.44 -1.32 0.54 1.57 0.56 3.09 0.17 -0.24 0.89
BDI change after 2-yrs -1.65 <.0001 -1.20 <.0001 -0.84 0.003 -0.91 .0001 -1.15 <.0001
FSS change after 2-yrs -3.63 0.13 -1.14 0.38 -3.66 0.02 -0.20 0.88 -2.65 0.02
MMSE-c change after 2-yrs -1.29 0.42 0.58 0.50 1.42 0.20 0.04 0.97 -1.40 0.6
Time** 5.68 0.37 5.31 0.11 4.15 0.32 -0.64 0.86 0.31 0.91
Time × IFN-β treatment (Yes vs no) -19.11 0.03 -4.95 0.27 -12.29 0.03 -9.65 0.05 2.53 0.54
  1. *Intercept value represents the baseline mean score for reference group (Untreated)
  2. **Time value represents the mean score change for reference group (Untreated) after 2 years of follow-up