Table 2 Time-varying covariates. Means ± SD at baseline and change after 2-years follow-up in untreated and treated MS groups
From: Influence of Interferon beta treatment on quality of life in multiple sclerosis patients
Untreated n. 77 | IFN-β treated n.41 | p-value* | ||||
|---|---|---|---|---|---|---|
Time-varying covariates | Baseline | Change | Baseline | Change | Baseline | Change |
Relapse rate** | 0.2 ± 0.3 | 0.0 ± 0.4 | 0.7 ± 0.5 | -0.1 ± 0.6 | <0.0001 | 0.37 |
EDSS | 3.1 ± 1.7 | 0.4 ± 0.8 | 3.0 ± 1.8 | 0.4 ± 1.1 | 0.84 | 0.93 |
BDI | 9.5 ± 7.7 | 1.3 ± 10.3 | 10.8 ± 9.2 | 2.2 ± 9.8 | 0.57 | 0.88 |
FSS | 2.5 ± 1.8 | 1.1 ± 1.7 | 2.8 ± 1.9 | 1.2 ± 1.8 | 0.53 | 0.75 |
MMSE-c | 28.5 ± 2.0 | -0.6 ± 2.4 | 28.1 ± 3.7 | -0.5 ± 2.5 | 0.78 | 0.70 |
MSQoL-54 Measures | ||||||
Physical health composite score | 65.5 ± 21.4 | -5.5 ± 17.2 | 65.1 ± 22.3 | -9.1 ± 18.9 | 0.91 | 0.45 |
Mental health composite score | 69.1 ± 19.8 | 1.2 ± 20.2 | 71.6 ± 18.2 | -12.1 ± 19.1 | 0.54 | 0.006 |
Physical function | 67.7 ± 35.8 | -2.3 ± 14.7 | 69.5 ± 35.4 | -8.8 ± 19.1 | 0.80 | 0.13 |
Health perceptions | 47.5 ± 23.4 | -3.0 ± 23.1 | 48.7 ± 22.7 | -6.0 ± 26.9 | 0.76 | 0.64 |
Energy | 47.7 ± 22.6 | 1.1 ± 23.0 | 47.0 ± 23.0 | -1.2 ± 23.0 | 0.91 | 0.57 |
Role limitation-physical | 67.6 ± 43.5 | -4.6 ± 42.9 | 65.2 ± 40.7 | -14.3 ± 41.8 | 0.48 | 0.52 |
Bodily pain | 79.7 ± 25.7 | -8.7 ± 30.9 | 74.0 ± 29.7 | -8.1 ± 28.6 | 0.39 | 0.41 |
Sexual function | 83.1 ± 26.6 | -6.0 ± 35.6 | 81.5 ± 27.0 | -12.0 ± 36.5 | 0.67 | 0.62 |
Social function | 74.2 ± 23.3 | -5.8 ± 23.4 | 74.4 ± 21.3 | -10.0 ± 21.5 | 0.87 | 0.49 |
Health distress | 70.8 ± 23.0 | -2.0 ± 31.6 | 71.9 ± 20.4 | -13.3 ± 24.0 | 0.98 | 0.06 |
Overall quality of life | 67.5 ± 19.0 | -1.0 ± 22.3 | 64.4 ± 18.8 | -8.6 ± 24.3 | 0.46 | 0.17 |
Cognitive function | 78.6 ± 20.6 | -0.4 ± 23.0 | 82.4 ± 20.6 | -12.2 ± 23.9 | 0.31 | 0.06 |
Emotional well-being | 57.1 ± 22.8 | 5.4 ± 43.2 | 59.5 ± 16.7 | -21.6 ± 42.5 | 0.65 | 0.014 |
Role limitation- emotional | 70.6 ± 43.3 | 0.4 ± 27.2 | 78.9 ± 36.3 | -6.4 ± 21.0 | 0.37 | 0.22 |
Satisfation with sexual function | 60.4 ± 26.7 | 2.0 ± 34.9 | 54.3 ± 30.6 | -3.7 ± 37.0 | 0.33 | 0.40 |
Change in health | 47.1 ± 19.9 | 0.5 ± 21.3 | 50.6 ± 22.7 | 4.6 ± 35.5 | 0.43 | 0.36 |