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Table 8 Estimates of MCID for PRO measures

From: The validity and responsiveness of three quality of life measures in the assessment of psoriasis patients: results of a phase II study

Change in Measure

MID-1: PASI Improvement 25–49%

MID-2: PASI Improvement 50–74%

MID-3: Difference Between Non-Responders (n = 34) and Minimal Responders (n = 41) on PGA

SEM

0.5 SD

DLQI Total Score

-4.05 (4.95)

-6.95 (5.71)

-5.69

2.33

3.59

SF-36

     

   Physical Functioning1

N/A

N/A

N/A

N/A

N/A

   Role-Physical

3.41 (51.35)

14.29 (31.20)

10.51

15.02

18.78

   Bodily Pain

11.59 (22.96)

16.76 (22.74)

9.05

10.76

12.69

   General Health

4.41 (18.37)

9.19 (11.29)

4.97

9.67

10.31

   Vitality

4.77 (20.44)

6.90 (17.43)

6.54

8.22

11.40

   Social Functioning

-1.70 (27.36)

13.10 (17.44)

13.62

10.67

13.78

   Role-Emotional

-7.58 (38.40)

17.46 (34.35)

24.71

14.59

17.70

   Mental Health

0.18 (18.66)

9.52 (13.53)

4.90

6.10

9.65

   Physical Summary Score (PCS)

3.91 (10.88)

2.57 (7.78)

0.51

2.71

5.12

   Mental Summary Score (MCS)

-1.82 (11.38)

6.05 (6.90)

6.61

3.89

5.61

EQ-5D

     

   Index Score

0.10 (0.24)

0.20 (0.21)

0.09

0.22

0.14

   VAS-General Health

3.82 (22.07)

8.43 (11.24)

4.59

N/A

10.34

  1. Note: MID-1 corresponds to the score for the PASI 25–49 group; MID-2 corresponds to the score for the PASI50-74; for MID-3 and MID-4, reliability estimates for computing SEM were obtained from the data in this study for the DLQI and from estimates found in the literature for the SF-36 and EQ-5D.
  2. 1MID estimates are not provided for the SF-36 Physical Function domain since there were not significant differences among responder groups.
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Health and Quality of Life Outcomes

ISSN: 1477-7525

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