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Table 7 PRO change scores corresponding to levels of PASI improvement

From: The validity and responsiveness of three quality of life measures in the assessment of psoriasis patients: results of a phase II study

Change in Measure PASI Improvement <25% (n = 31) PASI Improvement 25–49% (n = 22) PASI Improvement 50–74% (n = 21) PASI Improvement ≥75% (n = 66) Overall F Value p Values1
DLQI Total Score -0.16 (5.41) -4.05 (4.95) -6.95 (5.71) -12.17 (6.78) 30.4*** 2**,3***,5***,6*
SF-36       
   Physical Functioning 2.15 (17.67) 5.45 (23.60) 0.02 (22.36) 9.12 (23.50) 1.2  
   Role-Physical -11.29 (39.18) 3.41 (51.35) 14.29 (31.20) 20.08 (35.69) 4.9** 3**
   Bodily Pain -1.03 (21.42) 11.59 (22.96) 16.76 (22.74) 26.47 (27.40) 9.0*** 3***
   General Health -0.61 (17.33) 4.41 (18.37) 9.19 (11.29) 8.87 (15.62) 2.8*  
   Vitality -1.45 (16.29) 4.77 (20.44) 6.90 (17.43) 13.01 (22.58) 3.8* 3*
   Social Functioning -3.23 (23.71) -1.70 (27.36) 13.10 (17.44) 21.59 (28.13) 8.7*** 3***, 5**
   Role-Emotional -11.11 (36.44) -7.58 (38.40) 17.46 (34.35) 19.70 (32.54) 7.6*** 2*, 3**, 5*
   Mental Health -0.77 (18.08) 0.18 (18.66) 9.52 (13.53) 14.55 (17.77) 7.2*** 3**,5*
   Physical Summary -0.31 (7.18) 3.91 (10.88) 2.57 (7.78) 5.35 (9.67) 2.7*  
   Mental Summary -2.19 (9.86) -1.82 (11.38) 6.05 (6.90) 8.03 (10.59) 9.9*** 2*, 3***, 5**
EQ-5D       
   Index Score -0.01 (0.26) 0.10 (0.24) 0.20 (0.21) 0.25 (0.30) 7.1*** 3***
   VAS General Health 0.58 (24.31) 3.82 (22.07) 8.43 (11.24) 15.69 (18.96) 4.8** 3**
Mean PASI Improvement2 0.94 (4.07) -6.24 (2.99) -8.94 (3.47) -14.33 (7.65)   
  1. 1Pairwise comparisons between means were performed using Scheffe's test adjusting for multiple comparisons. 1 = improvement <25% vs. improvement 25–49%, 2 = improvement <25% vs. improvement 50–74%, 3 = improvement <25% vs. improvement ≥ 75%, 4 = improvement 25–49% vs. improvement 50–74%, 5 = improve 25–49% vs. improvement ≥ 75%, and 6 = improvement 50–74% vs. improvement ≥ 75%. *p < 0.05, **p < 0.01, ***p < 0.001.
  2. 2Negative change scores indicate improvement.