Skip to main content

Table 6 Change in PRO measures among responder1 groups

From: The validity and responsiveness of three quality of life measures in the assessment of psoriasis patients: results of a phase II study

Change in Measure Mean Change Score for Responders (n = 66) Mean Change Score for Non-Responders (n = 53) Difference t-value P Value Effect Size
DLQI Total Score -12.17 (6.78) -1.77 (5.52) -10.39 9.0 <.0001 0.40
SF-36       
   Physical Functioning 9.12 (23.50) 3.52 (20.19) 5.59 1.4 0.1724 0.01
   Role-Physical 20.08 (35.69) -5.19 (44.76) 25.26 3.4 0.0008 0.08
   Bodily Pain 26.47 (27.40) 4.21 (22.74) 22.26 4.7 <.0001 0.15
   General Health 8.87 (15.62) 1.47 (17.77) 7.39 2.4 0.0178 0.04
   Vitality 13.01 (22.58) 1.13 (18.20) 11.87 3.1 0.0024 0.07
   Social Functioning 21.59 (28.13) -2.59 (25.04) 24.19 4.9 <.0001 0.16
   Role-Emotional 19.70 (32.54) -9.62 (36.95) 29.31 4.6 <.0001 0.14
   Mental Health 14.55 (17.77) -0.38 (18.15) 14.92 4.5 <.0001 0.14
   Physical Summary Score (PCS) 5.35 (9.67) 1.47 (9.08) 3.88 2.2 0.0287 0.03
   Mental Summary Score (MCS) 8.03 (10.59) -2.03 (10.42) 10.06 5.1 <.0001 0.17
EQ-5D       
   Index Score 0.25 (0.30) 0.04 (0.26) 0.22 4.2 <.0001 0.12
   VAS General Health 15.69 (18.96) 1.92 (23.24) 13.77 3.5 0.0006 0.09
  1. 1Responder is defined as PASI improvement ≥ 75%; non-responder is defined as PASI improvement <50%.