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Table 2 Mean change in scores from baseline to week 48: Responsiveness based on clinical improvement (clearing of the target nail)

From: The OnyCOE-t™ questionnaire: responsiveness and clinical meaningfulness of a patient-reported outcomes questionnaire for toenail onychomycosis

  Clinically improved N = 400 Clinically not improved N = 52
Symptom Frequency 34.5 (<.0001) 21.2 (<.0001)
Symptom Bothersomeness 24.1 (<.0001) 14.5 (.0022)
Physical Activities Problems 30.1 (<.0001) 11.3 (.0100)
Appearance Problems 34.4 (<.0001) 13.6 (.0013)
Overall Problem 44.0 (<.0001) 24.5 (<.0001)
Stigma 15.4 (<.0001) 5.1 (.1416)
Treatment Satisfaction 46.1 (<.0001) 1.7 (.8868)
  1. (p-values are from the one-sample t-test)