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Table 2 Mean change in scores from baseline to week 48: Responsiveness based on clinical improvement (clearing of the target nail)

From: The OnyCOE-t™ questionnaire: responsiveness and clinical meaningfulness of a patient-reported outcomes questionnaire for toenail onychomycosis

 

Clinically improved N = 400

Clinically not improved N = 52

Symptom Frequency

34.5 (<.0001)

21.2 (<.0001)

Symptom Bothersomeness

24.1 (<.0001)

14.5 (.0022)

Physical Activities Problems

30.1 (<.0001)

11.3 (.0100)

Appearance Problems

34.4 (<.0001)

13.6 (.0013)

Overall Problem

44.0 (<.0001)

24.5 (<.0001)

Stigma

15.4 (<.0001)

5.1 (.1416)

Treatment Satisfaction

46.1 (<.0001)

1.7 (.8868)

  1. (p-values are from the one-sample t-test)