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Table 2 Included studies on GH therapy and psychological variables

From: Differential effect sizes of growth hormone replacement on quality of life, well-being and health status in growth hormone deficient patients: a meta-analysis

First author, year [ref]

N

Mean age (range) (years)

Duration therapy (months)

Trial design

Tests

Ahmad, 2001 [28]

46

Unknown

3

Open

QoL-AGHDA

Baum, 1998 [29]

40

Median 51 (24–64)

18

Controlled

NHP, PGWB, GHQ, MMPI-2

Burman, 1995 [30]

36

46 (28–57)

9

Controlled

NHP, PGWB, HSCL

Carroll, 1997 [31]

38

42.9

6

Controlled

NHP, PGWB

Cuneo, 1998 [32]

83

41.2

12

Controlled-open

NHP

Degerblad, 1990 [33]

6

20–38

3

Controlled

Sjoberg, POMS

Deijen, 1998 [34]

48

27 (19–37)

24

Controlled-open

POMS vigor, STAI state, HSCL

Giusti, 1998 [35]

26

51 (21–74)

6

Controlled

KSQ, HDS

Hernberg, 2001 [36]

304

M: 50.8

F: 48.6

12

Open

QoL-AGHDA, VAS

Murray, 1999 [37]

65

38.7 (17–72)

8

Open

QoL-AGHDA, PGWB

Sartorio, 1995 [38]

8

29.6 (25–34)

6

Open

Dysphoria, Anxiety

Soares, 1999 [39]

9

39.4 (28–52)

12

Controlled-open

HDS, BDI

Stouthart, 2003 [9]

20

21 (17–27)

12

Open

QLS, STAI, POMS, SCL-90, HSCL

Wallymahmed, 1997 [40]

30

35

24

Controlled-open

NHP, MFQ

Wiren, 1998 [41]

71

45 (19–76)

24

Open

NHP, PGWB

  1. BDI = Beck Depression Inventory; GHQ = General Health Questionnaire; HSCL = Hopkins Symptom Check list; HDS = Hamilton Depression Scale; MFQ = Mental Fatigue Questionnaire; MMPI-2 = Minnesota Multiphasic Personality Inventory-2; NHP = Nottingham Health Profile; KSQ = Kellner Symptom Questionnaire; PGWB = Psychological General Well Being Schedule; POMS = Profile of Mood States; SCL-90 = Symptoms Check List-90; Sjöberg = Sjöberg mood questionnaire; STAI = State-Trait Anxiety Inventory; QLS = Quality of Life Scale; QoL-AGHDA = Quality of Life Assessment of Growth Hormone Deficiency in Adults; VAS = Visual Analogue Scale.