Table 5 Responsiveness of the FSS score
From: Validation of the Fatigue Severity Scale in chronic hepatitis C
| FSS scores | Treatment-naïve | Treatment-experienced | ||
|---|---|---|---|---|
| (PILLAR) | (ASPIRE) | |||
| Mean CFB (SD) | P value | Mean CFB (SD) | P value | |
| Hemoglobin | ||||
| Baseline to Week 24a | ||||
| Worsened | 1.3 (1.61) | 1.0 (1.47) | ||
| Not worsened | 0.8 (1.48) | n.s. | 0.8 (1.51) | n.s. |
| EOT to 24-wk FUb | ||||
| Improved | -1.6 (1.73) | -1.3 (1.55) | ||
| Unimproved | -1.1 (1.38) | ** | -1.0 (1.52) | n.s. |
| EQ-5D VAS | ||||
| Baseline to Week 24 | ||||
| Worsened | 1.6 (1.61) | 1.5 (1.47) | ||
| Not worsened | 0.5 (1.33) | *** | 0.5 (1.33) | *** |
| EOT to 24-wk FU | ||||
| Improved | -2.1 (1.62) | -1.6 (1.65) | ||
| Unimproved | -0.8 (1.37) | *** | -0.7 (1.23) | *** |
| EQ-5D “Usual Activities” | ||||
| Baseline to Week 24 | ||||
| “No problems” to “some problems” | 1.90 (1.51) | 1.72 (1.44) | ||
| Not worsened | 0.52 (1.35) | *** | 0.57 (1.34) | *** |
| EOT to 24-wk FU | ||||
| “Some problems” to “no problems” | -2.27 (1.68) | -2.05 (1.53) | ||
| Unimproved | -0.98 (1.30) | *** | -0.80 (1.35) | *** |