Table 5 The prognostic effect of QLQ C-30 variables 3 months after NSCLC diagnosis on survival (bivariate and multivariate analyses)

Functioning domains (100 = good)

Physical functioning ≥50

0.612

0.431 - 0.869

0.006

0.787

0.506 - 1.226

0.289

Role functioning ≥50

0.640

0.469 - 0.874

0.005

0.907

0.573 - 1.437

0.677

Cognitive functioning ≥50

0.916

0.554 - 1.152

0.733

Social functioning ≥50

0.656

0.477 - 0.900

0.009

1.058

0.695 - 1.609

0.794

Emotional functioning ≥50

0.841

0.604 - 1.170

0.304

Symptom domains (100 = severe)

Pain <50

0.774

0.567 - 1.056

0.106

Fatigue <50

0.616

0.445 - 0.851

0.003

0.703

0.471 - 1.049

0.084

Sleep disturbance <50

0.876

0.641 - 1.197

0.406

Constipation <50

0.660

0.460 - 0.948

0.024

0.786

0.523 - 1.181

0.246

Nausea and vomiting <50

0.624

0.434 - 0.897

0.011

0.849

0.529 - 1.363

0.498

Apetite loss <50

0.628

0.457 - 0.863

0.004

0.890

0.599 - 1.324

0.567

Diarhoea <50

0.660

0.373 - 1.168

0.153

Dyspnea <50

1.095

0.803 - 1.491

0.567

Patient characteristics

Age

1.011

0.979 - 1.044

0.497

1.085

1.023 - 1.152

0.007

Sex:

 - Men

1

1

 - Women

0.732

0.293 - 1.831

0.505

0.633

0.411 - 0.976

0.038

Education level:

 - Primary

1

 - Secondary

0.783

0.554 - 1.107

0.167

 - Post secondary

0.695

0.352 - 1.372

0.294

Stage of cancer

 - Stage I - II

1

1

 - Stage III

1.971

0.916 - 4.239

0.011

13.463

2.036 - 89.038

0.007

 - Stage IV

4.898

1.518 - 15.801

<0.001

207.281

6.471 - 6639.251

0.003

Treatment before the HRQoL measurement

 - Chemotherapy only

1

1

 - Chemo and radiotherapy

0.656

0.388 - 1.109

0.115

0.635

0.366 - 1.103

0.107

 - Surgery alone or surgery and radiotherapy or chemotherapy

0.229

0.152 - 0.345

<0.001

0.227

0.143 - 0.363

<0.001

Interaction

Age*stage of cancer

0.973

0.947 - 1.000

0.049

0.959

0.932 - 0.987

0.004

Model with global health only

Bivariate analysis

Multivariate analysis

Variables

HR

95% CI

p

HR

95% CI

p

(100 = good)

Global HRQoL ≥50

0.688

0.504 - 0.938

0.018

0.689

0.501 - 0.946

0.021

Patient characteristics

Age

1.011

0.979 - 1.044

0.497

1.083

1.022 - 1.147

0.007

Sex:

 - Men

1

1

 - Women

0.732

0.293 - 1.831

0.505

0.682

0.452 - 1.029

0.068

Education level:

 - Primary

1

 - Secondary

0.783

0.554 - 1.107

0.167

 - Post secondary

0.695

0.352 - 1.372

0.294

Stage of cancer

 - Stage I - II

1

1

 - Stage III

1.971

0.916 - 4.239

0.011

11.982

1.881 - 76.310

0.009

 - Stage IV

4.898

1.518 - 15.801

<0.001

167.961

5.666 - 4979.331

0.003

Treatment before the HRQoL measurement

 - Chemotherapy only

1

1

 - Chemo and radiotherapy

0.656

0.388 - 1.109

0.115

0.690

0.406 - 1.173

0.171

 - Surgery alone or surgery and radiotherapy or chemotherapy

0.229

0.152 - 0.345

<0.001

0.239

0.151 - 0.377

<0.001

Interaction

Age*stage of cancer

0.973

0.947 - 1.000

0.049

0.962

0.935 - 0.989

0.007