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Table 4 The prognostic effect of SF-36 HRQoL dimensions 3 months after NSCLC diagnosis on survival (bivariate and multivariate analyses)

From: Quality of life after the initial treatments of non-small cell lung cancer: a persistent predictor for patients’ survival

Model without general health

Variables

Bivariate analysis

Multivariate analysis

 

HR

95% CI

P

HR

95% CI

p

HRQoL dimensions

     

Physical functioning ≥50

0.750

0.550 - 1.023

0.069

0.946

0.667 - 1.341

0.755

Physical role ≥50

0.651

0.428 - 0.991

0.046

0.576

0.326 - 1.016

0.057

Bodily pain ≥50

0.590

0.430 - 0.810

0.001

0.580

0.400 - 0.840

0.004

Emotional role ≥50

0.665

0.452 - 0.980

0.039

1.564

0.923 - 2.648

0.096

Social functioning ≥50

0.676

0.489 - 0.933

0.017

0.652

0.455 - 0.935

0.020

Mental health ≥50

0.792

0.581 - 1.081

0.142

   

Vitality ≥50

0.605

0.405 - 0.905

0.015

0.784

0.472 - 1.303

0.349

Patient characteristics

    

Age

1.002

0.9 - 1.02

0.798

1.102

1.041 - 1.167

<0.001

Sex:

      

 - Men

1

  

1

  

 - Women

0.859

0.575 - 1.285

0.460

0.556

0.351 - 0.881

0.012

Education level:

      

 - Primary

1

     

 - Secondary

0.820

0.581 - 1.157

0.259

   

 - Post secondary

0.739

0.374 - 1.461

0.384

   

Stage of cancer

      

 - Stage I - II

1

  

1

  

 - Stage III

1.670

1.088 - 2.565

0.019

21.388

3.460 - 132.187

0.001

 - Stage IV

3.341

2.025 - 5.511

<0.001

633.964

21.799 - 18437.11

<0.001

Treatment before the HRQoL measurement

    

 - Chemotherapy only

1

  

1

  

 - Chemo and radiotherapy

0.691

0.420 - 1.138

0.146

0.651

0.387 - 1.095

0.106

 - Surgery alone or surgery and radiotherapy or chemotherapy

0.219

0.144 - 0.333

<0.001

0.186

0.115 - 0.300

<0.001

Interaction

      

Age * Stage of cancer

0.969

0.945 - 0.994

0.016

0.952

0.926 - 0.978

<0.001

  1. *The interaction between Age and Stage of cancer.
  2. HR = hazard ratio; 95% CI = 95% confidence interval.
  3. Scores range from 0 to 100, with high scores reflecting better QoL.