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Table 4 The prognostic effect of SF-36 HRQoL dimensions 3 months after NSCLC diagnosis on survival (bivariate and multivariate analyses)

From: Quality of life after the initial treatments of non-small cell lung cancer: a persistent predictor for patients’ survival

Model without general health
Variables Bivariate analysis Multivariate analysis
  HR 95% CI P HR 95% CI p
HRQoL dimensions      
Physical functioning ≥50 0.750 0.550 - 1.023 0.069 0.946 0.667 - 1.341 0.755
Physical role ≥50 0.651 0.428 - 0.991 0.046 0.576 0.326 - 1.016 0.057
Bodily pain ≥50 0.590 0.430 - 0.810 0.001 0.580 0.400 - 0.840 0.004
Emotional role ≥50 0.665 0.452 - 0.980 0.039 1.564 0.923 - 2.648 0.096
Social functioning ≥50 0.676 0.489 - 0.933 0.017 0.652 0.455 - 0.935 0.020
Mental health ≥50 0.792 0.581 - 1.081 0.142    
Vitality ≥50 0.605 0.405 - 0.905 0.015 0.784 0.472 - 1.303 0.349
Patient characteristics     
Age 1.002 0.9 - 1.02 0.798 1.102 1.041 - 1.167 <0.001
Sex:       
 - Men 1    1   
 - Women 0.859 0.575 - 1.285 0.460 0.556 0.351 - 0.881 0.012
Education level:       
 - Primary 1      
 - Secondary 0.820 0.581 - 1.157 0.259    
 - Post secondary 0.739 0.374 - 1.461 0.384    
Stage of cancer       
 - Stage I - II 1    1   
 - Stage III 1.670 1.088 - 2.565 0.019 21.388 3.460 - 132.187 0.001
 - Stage IV 3.341 2.025 - 5.511 <0.001 633.964 21.799 - 18437.11 <0.001
Treatment before the HRQoL measurement     
 - Chemotherapy only 1    1   
 - Chemo and radiotherapy 0.691 0.420 - 1.138 0.146 0.651 0.387 - 1.095 0.106
 - Surgery alone or surgery and radiotherapy or chemotherapy 0.219 0.144 - 0.333 <0.001 0.186 0.115 - 0.300 <0.001
Interaction       
Age * Stage of cancer 0.969 0.945 - 0.994 0.016 0.952 0.926 - 0.978 <0.001
  1. *The interaction between Age and Stage of cancer.
  2. HR = hazard ratio; 95% CI = 95% confidence interval.
  3. Scores range from 0 to 100, with high scores reflecting better QoL.