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Table 4 Improvement of the GERCOR prognostic index

From: Could baseline health-related quality of life (QoL) predict overall survival in metastatic colorectal cancer? The results of the GERCOR OPTIMOX 1 study

GERCOR prognostic index

Variable

HR (95% CI)

P value

c-index

Schemper (%)

NRI (95% CI)

GERCOR (2 vs. 1)

1.82 [1.43 – 2.33]

<0.0001

   

    GERCOR (3 vs. 1)

3.10 [2.38 – 4.05]

<0.0001

0.63 [0.61 -0.66] *0.63

6.44

 

Improvement of the GERCOR prognostic index clinical and QoL factors: complete-case analysis

GERCOR (2 vs. 1)

1.70 [1.14 – 2.54]

=0.0090

  

NRI at 12 months = 0.35 [0.06; 0.44]

GERCOR (3 vs. 1)

3.35 [2.20 – 5.10]

<0.0001

0.67 [0.63 -0.71] *0.67

11.52

NRI at 24 months = 0.27 [0.04; 0.38]

 

NRI at 36 months = 0.28 [0.01; 0.45]

Mobility (2–3 vs. 1)

1.77 [1.19 – 2.62]

=0.0047

   

Anxiety/depression (2–3 vs. 1)

1.41 [1.03 – 1.92]

=0.0314

   

Improvement of the GERCOR prognostic index clinical and QoL factors: multiple imputation

GERCOR (2 vs. 1)

1.77 [1.36 – 2.30]

<0.0001

   

GERCOR (3 vs. 1)

2.49 [1.84 – 3.38]

<0.0001

   

ALP (>1ULN vs. ≤ 1ULN)

1.25 [1.00 – 1.57]

=0.0480

0.67 [0.64 -0.71]

9.56 [8.76 – 11.52]

 

Mobility (2–3 vs. 1)

1.42 [1.08 – 1.86]

=0.0120

R = 60%

  

Pain/discomfort (2–3 vs. 1)

1.55 [1.10 – 2.20]

=0.0140

R = 138%

  
  1. LD = lactate dehydrogenase.
  2. ULN = Upper Limit of Normal.
  3. * = bootstrap C-index.
  4. R = relative increase in variance due to missing data.
  5. QoL = Quality of Life.
  6. HR = Hazard ratio.
  7. NRI = net reclassification improvement.
  8. For multiple imputations, a logistic model was used: response variable=QoL scale (2–3 vs. 1) and exploratory variables were number of metastatic sites, liver involvement, WHO Performance Status, CEA, APL and LDH.
  9. Variables considered in the imputation method (last model) were selected more than 5 times among the 10 replications of multiple imputations (see statistical method).