Table 3 Recalibration component of response shift effect assessed with the then-test method at each measurement time
Baseline HRQoL | Then-test 1 minus pre-test | Then-test 2 minus pre-test | HRQoL at three months | Then-test 3 minus pre-test | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | Mean (SD) | N | Mean (SD) | P | Effect size | N | Mean (SD) | P | Effect size | N | Mean (SD) | N | Mean (SD) | P | Effect size | |
QLQ-C30 | ||||||||||||||||
Global Health Status | 310 | 68.66 (20.52) | 280 | -0.80 (16.67) | 0.600 | -0.04 | 275 | -4.21 (18.45) | <0.001 | -0.21 | 300 | 60.02 (20.19) | 266 | 0.91 (21.30) | 0.48 | 0.05 |
Physical functioning | 313 | 90.01 (15.50) | 283 | -0.50 (10.78) | 0.987 | -0.03 | 280 | -1.59 (13.26) | 0.053 | -0.11 | 301 | 81.31 (16.76) | 273 | 5.10 (14.52) | <0.001 | 0.31 |
Role functioning | 309 | 89.28 (20.38) | 281 | -1.90 (18.70) | 0.182 | -0.09 | 282 | -6.50 (23.72) | <0.001 | -0.32 | 300 | 74.06 (30.16) | 269 | 8.55 (28.99) | <0.001 | 0.30 |
Emotional functioning | 308 | 64.86 (26.20) | 279 | 5.36 (18.64) | <0.001 | 0.21 | 280 | 6.97 (21.48) | <0.001 | 0.27 | 300 | 72.80 (22.54) | 270 | -2.85 (24.55) | 0.054 | -0.11 |
Cognitive functioning | 313 | 83.23 (20.76) | 280 | 2.80 (14.97) | 0.027 | 0.13 | 281 | 2.37 (18.27) | 0.041 | 0.11 | 301 | 82.84 (21.11) | 239 | 4.03 (20.80) | 0.004 | 0.17 |
Social functioning | 307 | 90.34 (18.88) | 264 | -0.51 (16.18) | 0.644 | -0.03 | 276 | -5.01 (20.70) | <0.001 | -0.27 | 298 | 81.37 (25.42) | 266 | 6.02 (25.77) | <0.001 | 0.22 |
Fatigue | 310 | 22.89 (22.92) | 278 | -1.48 (18.22) | 0.039 | -0.06 | 279 | 1.75 (20.92) | 0.228 | 0.08 | 300 | 32.82 (24.08) | 270 | -11.03 (25.36) | <0.001 | -0.43 |
Nausea and vomiting | 312 | 3.53 (11.18) | 270 | -0.77 (8.34) | 0.130 | -0.07 | 282 | 1.77 (15.11) | 0.092 | 0.16 | 299 | 3.44 (10.90) | 269 | -3.22 (19.95) | 0.010 | -0.18 |
Pain | 316 | 12.45 (20.87) | 285 | 0.53 (19.04) | 0.897 | 0.02 | 283 | 3.24 (23.03) | 0.032 | 0.15 | 304 | 25.08 (24.82) | 274 | -6.02 (23.98) | <0.001 | -0.23 |
Dyspnea | 310 | 11.72 (31.87) | 280 | -2.02 (15.19) | 0.036 | -0.09 | 279 | -1.08 (15.58) | 0.333 | -0.05 | 301 | 12.86 (20.89) | 269 | -3.59 (24.08) | 0.009 | -0.15 |
Insomnia | 307 | 38.11 (31.87) | 277 | -5.30 (27.14) | 0.003 | -0.17 | 274 | -6.93 (30.94) | <0.001 | -0.22 | 299 | 36.63 (30.27) | 266 | -5.64 (32.59) | 0.002 | -0.18 |
Appetite loss | 312 | 11.75 (22.46) | 280 | -3.45 520.35 | 0.005 | -0.15 | 280 | -1.19 (23.75) | 0.323 | -0.05 | 299 | 10.20 (20.13) | 267 | -4.62 (25.02) | 0.004 | -0.18 |
Constipation | 310 | 12.47 (22.80) | 276 | -1.09 (21.15) | 0.520 | -0.05 | 277 | 1.56 (24.93) | 0.284 | 0.07 | 298 | 21.38 (30.87) | 264 | -4.29 (26.61) | 0.006 | -0.16 |
Diarrhea | 309 | 8.63 (16.48) | 278 | -2.88 (12.66) | <0.001 | -0.17 | 277 | -2.89 (17.25) | 0.010 | -0.17 | 296 | 4.76 (12.30) | 263 | -0.63 (22.07) | 0.483 | -0.04 |
Financial difficulties | 300 | 4.56 (14.60) | 264 | 0.38 (12.83) | 0.741 | 0.03 | 269 | 0.99 (16.51) | 0.453 | 0.07 | 299 | 5.86 (15.93) | 264 | -2.15 (18.14) | 0.048 | -0.10 |
QLQ-BR23 | ||||||||||||||||
Body image | 295 | 90.04 (17.32) | 262 | -0.76 (11.95) | 0.505 | -0.05 | 257 | -8.16 (16.96) | <0.001 | 0.48 | 302 | 70.76 (30.77) | 269 | 7.78 (24.82) | <0.001 | 0.25 |
Sexual functioning | 274 | 76.46 (24.01) | 232 | -0.50 (13.82) | 0.207 | -0.02 | 222 | -1.21 (15.92) | 0.206 | -0.05 | 267 | 79.65 (22.06) | 224 | -4.69 (18.52) | 0.002 | -0.21 |
Sexual enjoyment | 126 | 43.92 (28.79) | 99 | 2.36 (11.91) | 0.124 | 0.09 | 100 | 3.33 (22.97) | 0.284 | 0.12 | 138 | 52.17 (29.31) | 108 | -1.54 (23.41) | 0.548 | -0.06 |
Future perspective | 295 | 47.46 (30.86) | 261 | 7.41 (30.60) | <0.001 | 0.24 | 259 | 6.95 (32.47) | <0.001 | 0.23 | 301 | 54.49 (32.76) | 269 | -0.12 (33.02) | 0.968 | -0.01 |
STSE | 308 | 13.29 (15.30) | 280 | -1.71 (9.89) | 0.008 | -0.11 | 271 | 0.73 (13.84) | 0.563 | 0.05 | 301 | 25.13 (20.20) | 271 | -4.76 (19.52) | <0.001 | -0.24 |
Breast symptoms | 273 | 11.25 (14.92) | 243 | -0.73 (14.39) | 0.152 | -0.05 | 239 | 2.15 (19.76) | 0.379 | 0.14 | 302 | 24.73 (22.97) | 273 | -7.28 (20.70) | <0.001 | -0.31 |
Arm symptoms | 297 | 8.06 (14.42) | 268 | 1.58 (18.49) | 0.572 | 0.11 | 261 | 2.43 (16.53) | 0.011 | 0.17 | 302 | 16.39 (18.54) | 273 | -2.71 (17.70) | 0.010 | -0.15 |
Hair loss | 55 | 32.73 (36.57) | 34 | 0.98 (17.38) | 0.749 | 0.03 | 31 | 1.08 (25.07) | 0.506 | 0.03 | 131 | 53.69 (39.78) | 54 | -8.03 (40.92) | 0.173 | -0.21 |