Table 2 Mean changes in HRQoL scores from baseline to study phase completion (week 16) by ACR improvement categories, all dose groups combined
|  | ACR < 20% (n = 100) | ACR 20-49% (n = 49) | ACR 50-69% (n = 24) | ACR 70% (n = 9) | F | p-value |
|---|---|---|---|---|---|---|
PRO Instruments | Â | Â | Â | Â | Â | Â |
SF-36 | Â | Â | Â | Â | Â | Â |
Physical functioning | 2.1 (15.6) | 8.5 (17.2) | 17.9 (18.5) | 24.4 (28.4) | 9.1 | 0.0000 |
Role physical | 2.7 (17.3) | 12.8 (22.5) | 23.9 (23.5) | 27.8 (35.2) | 10.2 | 0.0000 |
Bodily pain | 0.4 (14.7) | 18.1 (16.6) | 24.0 (19.0) | 39.1 (13.2) | 33.1 | 0.0000 |
General health | -1.9 (12.7) | 4.7 (12.8) | 15.9 (13.6) | 18.7 (11.3) | 17.7 | 0.0000 |
Vitality | 0.1 (16.1) | 9.9 (19.6) | 18.5 (21.1) | 29.9 (24.8) | 13.2 | 0.0000 |
Social functioning | -1.5 (23.9) | 12.8 (21.9) | 7.8 (27.0) | 29.2 (37.0) | 7.0 | 0.0000 |
Role emotional | -2.1 (22.5) | 8.9 (27.2) | 13.5 (26.6) | 29.6 (27.0) | 7.1 | 0.0000 |
Mental health | -0.2 (15.2) | 6.8 (16.5) | 9.4 (23.6) | 23.9 (23.0) | 7.2 | 0.0000 |
Physical summary | 0.8 (4.9) | 4.6 (5.9) | 9.3 (6.1) | 10.1 (10.3) | 20.8 | 0.0000 |
Mental summary | -1.0 (8.9) | 4.0 (9.3) | 4.3 (12.9) | 13.7 (16.0) | 8.1 | 0.0000 |
FACIT-Fatigue | 0.6 (7.2) | 5.7 (7.2) | 8.8 (8.0) | 11.3 (4.5) | 14.9 | 0.0000 |