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Table 1 Overview of HRQOL assessment instruments and MCID [23]- [27]

From: Improvements in patient-reported outcomes with apremilast, an oral phosphodiesterase 4 inhibitor, in the treatment of moderate to severe psoriasis: results from a phase IIb randomized, controlled study

Instrument Description Scale MCID
Pruritus VAS Pruritus visual analog scale 0–100 mm, including “anchors” 10.0 points
(best to worst)
DLQI Dermatology Life Quality Index 0–30 points 5.0 points
Subject report, 10 questions addressing: (best to worst)
– Symptoms
– Feelings
– Daily activities
– Leisure
– Work
– Personal relationships
SF-36 domains* Patient report, 36 items 0–100 mm 5.0 points
– Physical Functioning (worst to best)
– Role-Physical
– Bodily Pain
– General Health
– Vitality
– Role-Emotional
– Social Functioning
– Mental Health
SF-36 PCS and MCS scores Calculated based upon domain scores Normative value: mean=50, SD=10 2.5 points
  1. *Based on transformed scale scores.
  2. HRQOL, health-related quality of life; MCID, minimum clinically important differences; MCS, mental component summary; PCS, physical component summary; SF-36, 36-Item Short-Form Health Survey version 2.