SF-36 domain scores at baseline and week 16 with apremilast 30 mg BID. Spydergram of SF-36 domain scores in patients receiving apremilast 30 mg BID versus US age-/gender-matched norms (lavender) and baseline (dark blue). Gridlines represent changes of 10 points each (10 = 2× MCID of 5 points). An increase in score indicates improvement. Treatment associated improvements (light blue) are statistically significant in four of eight domains and ≥MCID in three of eight domains. MCID, minimal clinically important difference; SF-36, 36-item Short-Form Health Survey.*≥MCID.