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Table 3 Characteristics of the clinical sample with treated hypothyroidism in proven autoimmune thyroid disease and the healthy control group

From: Patient-reported outcomes in adequately treated hypothyroidism – insights from the German versions of ThyDQoL, ThySRQ and ThyTSQ

Sample characteristics Treated patient group n = 18 Healthy control group n = 18 p-value
  Mean SD Range Mean SD Range  
Age (years) 32.2 9.60 [18–54] 32.1 8.90 [18–53] >0.1
Sex (female/male) 16/2 16/2 >0.1
TSH (mU/l)* 1.96 1.42 [0.2 - 5.3] 2.63 0.95 [0.9 - 5.0] <0.05
fT3 (pmol/l)* 4.28 0.62 [3.2 - 5.6] 4.72 0.83 [3.2 - 6.3] =0.07
fT4 (pmol/l)* 18.2 1.61 [14–21] 15.6 2.24 [14–23] <0.001
TPOAb (U/ml)* 140 132 [9–457] 10.2 2.14 [7–14] <0.001
TgAb (U/ml)* 313 604 [5–2424] 17.3 7.47 [5–36] <0.001
Treatment duration (years) 4.41 4.21 [1–15] not applicable
Current dose (μg/day) 96.5 29.6 [50–150]     
  1. *laboratory values of initial blood sample, reference range was 0.4-4.0 for Thyroid Stimulating Hormone (TSH), 3.1-6.79 for free Triiodothyronine (fT3), 12.8-20.4 for free Thyroxine (fT4), < 34 for Thyroid Peroxidase Antibodies (TPOAb) and < 33 for Thyroglobulin Antibodies (TgAb) [4, 35]. Patients with slightly altered laboratory values that spontaneously recovered to the normal range in a second blood sample taken 3–6 months later were considered as thyroid healthy or adequately treated and included into the analysis. Abbreviaton: SD – Standard Deviation.