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Table 4 Estimated Minimal Clinically Important Differences (MCIDs) and their 95% Confidence Intervals (CIs) for EQ-5D and QWB-SA using both anchor- and distribution-based approaches

From: Minimal clinically important differences for the EQ-5D and QWB-SA in Post-traumatic Stress Disorder (PTSD): results from a Doubly Randomized Preference Trial (DRPT)

ANCHOR-BASED APPROACH DISTRIBUTION-BASED APPROACH
HRQOL health-utility CGI-I* CGI-S* Treatment response status† 0.2 SD 0.5 SD
EQ-5D 0.08 (0.04–0.11) 0.05 (0.03–0.07) 0.05 0.04 0.10
QWB-SA 0.05 (0.03–0.08) 0.03 (0.02–0.05) 0.03 0.02 0.05
  1. HRQOL, Health-Related Quality of Life; CGI-I, Clinical Global Impression-Improvement; CGI-S, Clinical Global Impression-Severity; SD, Standard Deviation at baseline or pre-treatment; EQ-5D, EuroQol Group-5 Dimensions; QWB-SA, Quality of Well-Being-Self Administration.
  2. * Anchor-based approach using ordinary least squares regression method (also refer to Figures 2 and 3).
  3. † Anchor-based approach using ROC curve analysis (also refer to Figure 4).