Minimal clinically important differences for the EQ-5D and QWB-SA in Post-traumatic Stress Disorder (PTSD): results from a Doubly Randomized Preference Trial (DRPT)

Table 4 Estimated Minimal Clinically Important Differences (MCIDs) and their 95% Confidence Intervals (CIs) for EQ-5D and QWB-SA using both anchor- and distribution-based approaches

ANCHOR-BASED APPROACH				DISTRIBUTION-BASED APPROACH
HRQOL health-utility	CGI-I*	CGI-S*	Treatment response status†	0.2 SD	0.5 SD
EQ-5D	0.08 (0.04–0.11)	0.05 (0.03–0.07)	0.05	0.04	0.10
QWB-SA	0.05 (0.03–0.08)	0.03 (0.02–0.05)	0.03	0.02	0.05

HRQOL, Health-Related Quality of Life; CGI-I, Clinical Global Impression-Improvement; CGI-S, Clinical Global Impression-Severity; SD, Standard Deviation at baseline or pre-treatment; EQ-5D, EuroQol Group-5 Dimensions; QWB-SA, Quality of Well-Being-Self Administration.
* Anchor-based approach using ordinary least squares regression method (also refer to Figures 2 and 3).
† Anchor-based approach using ROC curve analysis (also refer to Figure 4).

ISSN: 1477-7525