Outcomes | Estimated risk with Placebo | Absolute reduction in risk with Paroxetine | Relative effect (95% CI) | Number of participants (studies) |
Confidence in effect estimate
^{1}
| Comments |
---|---|---|---|---|---|---|

(A) Standard deviation units
| The depression score in the paroxetine groups was on average 0.31 SDs (0.24 to 0.38 lower than in the placebo groups) | --- | 5736 (34) |
⊕⊕ OO^{2,3} low
| As a rule of thumb, 0.2 SD represents a small difference, 0.5 moderate, and 0.8 large (Cohen, 1988) | |

(B) Natural units
| ||||||

Major depression measured on Hamilton Rating Scale for Depression, generally scored from 0 to 50, higher scores indicate more severe depression | The mean depression scores with placebo ranged from 3.1 to 11.3 | The mean depression score in the intervention groups was on average 2.47 (1.91 to 3.03) lower | 5736 (34) |
⊕⊕ OO^{2,3} low
| Scores estimated based on an SMD of 0.31 (95% CI 0.24 to 0.38)The minimal important difference on the 0 to 50 depression scale is 7 points. Although the depression score was on average only 2.47 lower, the corresponding NNT is 11 | |

(C) Risk difference
| 50 per 100 patients | 39 per 100 patients | OR=1.64 (95% CI 1.47 to 1.84) | 5736 (34) |
⊕⊕ OO^{2,3} low
| This approach uses binomial and equal variance assumptions and baseline risks, and demonstrates that for every 100 patients treated with paroxetine, 11 will achieve important improvement |

Differences in proportion achieving important improvement | ||||||

0.11 (95% CI 0.07 to 0.16) in favor of paroxetine | ||||||

(D) Ratio of means
| --- | --- | Ratio of means | 5736 (34) |
⊕⊕ OO^{2,3} low
| Weighted average of the mean depression score in paroxetine group divided by mean depression score in placebo. RoM method provides similar effect estimates compared with the traditionally used standard deviation unit, with SMDs of 0.2, 0.5, and 0.8, corresponding to increases in RoM of approximately 8%, 22%, and 37%, respectively (Friedrich 2011). |

1.27 (1.18 to 1.36) | ||||||

(E) Minimal important difference units
| The depression score in the paroxetine groups was on average 0.38 (95% CI 0.30 to 0.47) minimal important difference units less than the control group | --- | 5736 (34) |
⊕⊕ OO^{2,3} low
| An effect less than half the minimal important difference suggests a small effect |