Treatment group | n | Mean change from baseline | Mean difference from placebo | t-Value | Degrees of freedom | p-Value | Effect sizes | ||
---|---|---|---|---|---|---|---|---|---|
d Pooled | d Placebo | ||||||||
IBS-QOL total score, Observed Data(a) | 5 mg | 66 | 19.73 | 2.02 | 0.64 | 189 | 0.522 | 0.09 | 0.09 |
25 mg | 135 | 18.75 | 1.04 | 0.43 | 258 | 0.664 | 0.05 | 0.05 | |
100 mg | 130 | 25.25 | 7.54 | 3.10 | 253 | 0.002 | 0.39 | 0.33 | |
200 mg | 107 | 25.06 | 7.35 | 2.68 | 230 | 0.008 | 0.35 | 0.32 | |
Placebo | 125 | 17.70 | |||||||
IBS-QOL total score, Longitudinal Model(b) | 5 mg | 105 | 19.33 | 2.00 | 1.09 | 262 | 0.279 | 0.13 | 0.09 |
25 mg | 167 | 18.46 | 1.13 | 0.67 | 324 | 0.507 | 0.07 | 0.05 | |
100 mg | 163 | 24.53 | 7.20 | 4.20 | 320 | <.001 | 0.47 | 0.31 | |
200 mg | 160 | 23.33 | 6.00 | 3.64 | 317 | <.001 | 0.41 | 0.26 | |
Placebo | 159 | 17.33 |