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Table 4 Partial correlations between IBS-QOL total score and other clinical measures—controlling for dose level

From: Evaluation of the Irritable Bowel Syndrome Quality of Life (IBS-QOL) questionnaire in diarrheal-predominant irritable bowel syndrome patients

Variable

Time point

N

Correlation type

Correlation value

p-Value

IBS-SSS

Week 12

427

Pearson

-0.604

<0.0001

 

Change from Baseline

383

Pearson

-0.629

<0.0001

EQ-5D

Week 12

694

Pearson

0.581

<0.0001

 

Change from Baseline

690

Pearson

0.404

<0.0001

Pain/14-Day

Week 12

550

Pearson

-0.392

<0.0001

 

Change from Baseline

549

Pearson

-0.350

<0.0001

Pain/7-Day

Week 12

536

Pearson

-0.397

<0.0001

 

Change from Baseline

535

Pearson

-0.357

<0.0001

IBS-AR

Week 12

693

Point Biserial

0.379

<0.0001

(t-Test)

(10.788)

Biserial

0.483

<0.0001

(t-Test)

(14.523)

FDA clinical responder definition

Week 12

694

Point Biserial

0.282

<0.0001

(t-Test)

(7.750)

Biserial

0.395

<0.0001

(t-Test)

(11.316)

  1. Note: Point biserial and biserial correlation coefficients are evaluated via constructing a t-test.