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Table 4 Responsiveness of HRQoL and clinical symptoms

From: Estimating EQ-5D and OAB-5D health state utilities for patients with overactive bladder

A. Overall population
Clinical symptom Response in symptoms N (%) Change from baseline in utility EQ-5D, adjusted mean (±SD) a P value vs. ‘Stable’ b Change from baseline in utility OAB-5D, adjusted mean (±SD) a P value vs. ‘Stable’ b
Micturitions/24 h Improvement ≥ 1 level 2286 (56.4%) 0.046 (±0.213) 0.0058 0.076 (±0.092) <.0001
Stable 1260 (31.1%) 0.027 (±0.202) NA 0.039 (±0.087) NA
Worsening ≥ 1 level 506 (12.5%) 0.023 (±0.195) 0.7291 0.021 (±0.085) 0.0001
Incontinence episodes/24 h Improvement ≥ 1 level 1874 (46.3%) 0.053 (±0.223) 0.0002 0.081 (±0.096) <.0001
Stable 1849 (45.6%) 0.028 (±0.206) NA 0.042 (±0.089) NA
Worsening ≥ 1 level 329 (8.1%) 0.007 (±0.197) 0.0662 0.022 (±0.086) <.0001
B. Patients with mild symptoms at baseline (level 1 to 3 in terms of micturitions frequency, or incontinence episodes)
Clinical symptom Response in symptoms N (%) Change from baseline in utility EQ-5D, adjusted mean (±SD) a P value vs. ‘Stable’ b Change from baseline in utility OAB-5D, adjusted mean (±SD) a P value vs. ‘Stable’ b
Micturitions/24 h Improvement ≥ 1 level 1329 (50.7%) 0.046 (±0.205) 0.3518 0.079 (±0.089) <.0001
Stable 863 (32.9%) 0.038 (±0.197) NA 0.047 (±0.085) NA
Worsening ≥ 1 level 432 (16.5%) 0.029 (±0.189) 0.3886 0.021 (±0.082) <.0001
Incontinence episodes/24 h Improvement ≥ 1 level 1038 (35.9%) 0.049 (±0.197) 0.0416 0.079 (±0.099) <.0001
Stable 1564 (54.1%) 0.033 (±0.191) NA 0.046 (±0.102) NA
Worsening ≥ 1 level 287 (9.9%) 0.010 (±0.188) 0.0628 0.023 (±0.087) <.0001
C. Patients with severe symptoms at baseline (level 4 or 5 in terms of micturitions frequency, or incontinence episodes)
Clinical symptom Response in symptoms N (%) Change from baseline in utility EQ-5D, adjusted mean (±SD) a P value vs. ‘Stable’ b Change from baseline in utility OAB-5D, adjusted mean (±SD) a P value vs. ‘Stable’ b
Micturitions/24 h Improvement ≥ 1 level 957 (67.0%) 0.046 (±0.250) 0.0004 0.074 (±0.098) <.0001
Stable 397 (27.8%) 0.002 (±0.219) NA 0.020 (±0.090) NA
Worsening ≥ 1 level 74 (5.2%) -0.009 (±0.208) 0.6873 0.022 (±0.090) 0.8938
Incontinence episodes/24 h Improvement ≥ 1 level 836 (71.9%) 0.064 (±0.299) 0.0004 0.078 (±0.143) <.0001
Stable 285 (24.5%) 0.012 (±0.246) NA 0.014 (±0.111) NA
Worsening ≥ 1 level 42 (3.6%) -0.019 (±0.219) 0.3865 0.008 (±0.094) 0.7158
  1. A. aSD: Standard deviation. b t- test to test the null hypothesis that the associated utility change equals the utility change in patients with “Stable” response. NA: Not applicable.
  2. B. aSD: Standard deviation. b t- test to test the null hypothesis that the associated utility change equals the utility change in patients with “Stable” response. NA: Not applicable.
  3. C. aSD: Standard deviation. b t- test to test the null hypothesis that the associated utility change equals the utility change in patients with “Stable” response. NA: Not applicable.