Table 4 Responsiveness of HRQoL and clinical symptoms
From: Estimating EQ-5D and OAB-5D health state utilities for patients with overactive bladder
A. Overall population | ||||||
|---|---|---|---|---|---|---|
Clinical symptom | Response in symptoms | N (%) | Change from baseline in utility EQ-5D, adjusted mean (±SD) a | P value vs. ‘Stable’ b | Change from baseline in utility OAB-5D, adjusted mean (±SD) a | P value vs. ‘Stable’ b |
Micturitions/24 h | Improvement ≥ 1 level | 2286 (56.4%) | 0.046 (±0.213) | 0.0058 | 0.076 (±0.092) | <.0001 |
Stable | 1260 (31.1%) | 0.027 (±0.202) | NA | 0.039 (±0.087) | NA | |
Worsening ≥ 1 level | 506 (12.5%) | 0.023 (±0.195) | 0.7291 | 0.021 (±0.085) | 0.0001 | |
Incontinence episodes/24 h | Improvement ≥ 1 level | 1874 (46.3%) | 0.053 (±0.223) | 0.0002 | 0.081 (±0.096) | <.0001 |
Stable | 1849 (45.6%) | 0.028 (±0.206) | NA | 0.042 (±0.089) | NA | |
Worsening ≥ 1 level | 329 (8.1%) | 0.007 (±0.197) | 0.0662 | 0.022 (±0.086) | <.0001 | |
B. Patients with mild symptoms at baseline (level 1 to 3 in terms of micturitions frequency, or incontinence episodes) | ||||||
Clinical symptom | Response in symptoms | N (%) | Change from baseline in utility EQ-5D, adjusted mean (±SD) a | P value vs. ‘Stable’ b | Change from baseline in utility OAB-5D, adjusted mean (±SD) a | P value vs. ‘Stable’ b |
Micturitions/24 h | Improvement ≥ 1 level | 1329 (50.7%) | 0.046 (±0.205) | 0.3518 | 0.079 (±0.089) | <.0001 |
Stable | 863 (32.9%) | 0.038 (±0.197) | NA | 0.047 (±0.085) | NA | |
Worsening ≥ 1 level | 432 (16.5%) | 0.029 (±0.189) | 0.3886 | 0.021 (±0.082) | <.0001 | |
Incontinence episodes/24 h | Improvement ≥ 1 level | 1038 (35.9%) | 0.049 (±0.197) | 0.0416 | 0.079 (±0.099) | <.0001 |
Stable | 1564 (54.1%) | 0.033 (±0.191) | NA | 0.046 (±0.102) | NA | |
Worsening ≥ 1 level | 287 (9.9%) | 0.010 (±0.188) | 0.0628 | 0.023 (±0.087) | <.0001 | |
C. Patients with severe symptoms at baseline (level 4 or 5 in terms of micturitions frequency, or incontinence episodes) | ||||||
Clinical symptom | Response in symptoms | N (%) | Change from baseline in utility EQ-5D, adjusted mean (±SD) a | P value vs. ‘Stable’ b | Change from baseline in utility OAB-5D, adjusted mean (±SD) a | P value vs. ‘Stable’ b |
Micturitions/24 h | Improvement ≥ 1 level | 957 (67.0%) | 0.046 (±0.250) | 0.0004 | 0.074 (±0.098) | <.0001 |
Stable | 397 (27.8%) | 0.002 (±0.219) | NA | 0.020 (±0.090) | NA | |
Worsening ≥ 1 level | 74 (5.2%) | -0.009 (±0.208) | 0.6873 | 0.022 (±0.090) | 0.8938 | |
Incontinence episodes/24 h | Improvement ≥ 1 level | 836 (71.9%) | 0.064 (±0.299) | 0.0004 | 0.078 (±0.143) | <.0001 |
Stable | 285 (24.5%) | 0.012 (±0.246) | NA | 0.014 (±0.111) | NA | |
Worsening ≥ 1 level | 42 (3.6%) | -0.019 (±0.219) | 0.3865 | 0.008 (±0.094) | 0.7158 | |