Item selection, reliability and validity of the Shortness of Breath with Daily Activities (SOBDA) questionnaire: a new outcome measure for evaluating dyspnea in chronic obstructive pulmonary disease

Table 1 Inclusion and exclusion criteria

Key criteria
Inclusion	Exclusion
Current clinical diagnosis of COPD based on the GOLD 2008 guideline criteria [20]
Ages 40–80 years
Current or former smoker with smoking history of ≥ 10 pack-years
Evidence of SOB confirmed by clinician mMRC dyspnea rating of ≥ 2 for GOLD spirometric classifications II–IV patients
	Experienced an exacerbation in the 60 days preceding enrolment
	Concurrent diagnosis of asthma
	Known respiratory disorders other than COPD^a
	Organic heart disease with resultant left ventricular failure and New York Heart Association class 2–4
	Known neuromuscular disease

^aα-1 antitrypsin deficiency as the underlying cause of COPD, active tuberculosis, lung cancer, bronchiectasis, sarcoidosis, lung fibrosis, pulmonary hypertension and interstitial lung disease.
COPD Chronic obstructive pulmonary disease.
mMRC Modified Medical Research Council.

ISSN: 1477-7525