Evaluation of health related quality of life in children with immune thrombocytopenia with the PedsQL™ 4.0 Generic Core Scales: a study on behalf of the pays de Loire pediatric hematology network

Table 3 Health related quality of life scores for ITP children and adolescents

	ITP diagnosis (n = 73)						ITP month 6 (n = 55)				Δ	Original norm data ¹		Healthy children, France ²(n = 185)
	Mean	SD	% floor	% ceiling	Cronbach α coefficient	MCID	Mean	SD	% floor	% ceiling		Mean	SD	Mean	SD
Children
Global score	80.6	10.7	0.0	0.0	0.83	4.3	85.1	16.2	0.0	10.8	4.5*	83.8	12.6	77.6	12.5
Physical summary score	86.0	10.4	0.0	22.0	0.88	3.6	88.4	12.7	0.0	33.3	2.4	87.5	13.5	81.6	13.5
Psychosocial summary score	77.7	14.1	0.0	0.0	0.71	7.6	84.1	13.9	0.0	10.8	6.4	81.9	14.0	75.5	14.3
Emotional functioning	72.0	18.6	0.0	12.8	0.80	8.3	81.4	17.8	0.0	27.0	9.4*	79.3	18.1	69.8	18.4
Social functioning	86.4	16.2	0.0	30.0	0.81	7.0	90.7	13.8	0.0	48.6	4.3	85.1	16.7	80.5	17.9
School functioning	74.0	16.2	0.0	5.1	0.77	7.7	79.9	17.6	0.0	16.6	5.9	81.1	16.4	76.4	16.6
Parent
Global score	82.7	12.3	0.0	4.1	0.85	4.6	87.2	12.5	0.0	14.5	4.5	82.7	15.4	80.4	12.1
Physical summary score	87.2	14.3	0.0	30.1	0.86	5.3	90.8	13.1	0.0	42.8	3.6	84.5	19.5	85.7	13.7
Psychosocial summary score	80.2	14.0	0.0	5.5	0.76	6.8	85.2	13.4	0.0	14.5	5	81.7	15.2	77.4	13.2
Emotional functioning	71.1	19.5	0.0	12.6	0.83	8.1	77.5	20.1	0.0	22.2	6.4	81.3	16.5	71.8	16.3
Social functioning	89.5	14.2	0.0	47.2	0.84	5.5	93.5	11.6	0.0	66.0	4	83.7	19.4	84.4	16.2
School functioning	80.6	18.1	0.0	24.6	0.82	7.6	86.1	14.3	0.0	30.1	5.5	78.8	19.6	76.1	16.7

% Floor/Ceiling = the proportion of scores at the extremes of the scaling range/SD = Standard deviation. Impaired health-related QOL was defined as a score that was more than 1 SD below the healthy sample mean/MCID = Minimal Clinically Important Difference. Standard Error of measurement computed by multiplying the standard deviation at diagnosis by the square root of 1 - alpha (Cronbach alpha coefficient)/Δ = the difference between mean scores at diagnosis and month 6. An improvement in quality of life between diagnosis and month 6 requires a Δ at least equal to the value of MCID score.
*p < 0.01.
¹Varni et al., 2007: correspond to the standards obtained from a population of 5480 healthy US children ().
²Tessier et al., 2009.

ISSN: 1477-7525