Preference-based Health status in a German outpatient cohort with multiple sclerosis

Table 3 Percentage of age-grouped individuals with problems in the different EQ-5D dimensions

	Mobility			Self-care			Usual activities			Pain			Anxiety/depression
	Tot.	M	F	Tot.	M	F	Tot.	M	F	Tot.	M	F	Tot.	M	F
Gen. Pop. ¹[%]	15.9	14.9	16.8	2.8	2.2	3.4	9.9	8.9	10.7	27.6	24.9	30.0	4-3	3.6	4.9
MS ²[%]	60.4	55.6	62.6	19.4	22.2	18.2	65.3	62.2	66.7	69.4	62.2	72.7	56.3	44.4	61.6
	UV OR [CI]	MV OR [CI]		UV OR [CI]	MV OR [CI]		UV OR [CI]	MV OR [CI]		UV OR [CI]	MV OR [CI]		UV OR [CI]	MV OR [CI]
RRMS^§	.077** [.026;.232]	n.s.		.07** [.04;.25]	n.s.		.10** [.03;.31]	n.s.		n.s.	n.s.		n.s.	17.92* [1.50;214.83]
SPMS	8.92** [2.96;26.87]	n.s.		8.14** [3.29;20.15]	n.s.		9.72** [2.82;33.57]	n.s.		n.s.	n.s.		n.s.	22.83* [1.94;269.30]
Age	1.11** [1.07;1.15]	n.s.		1.11** [1.06;1.16]	n.s.		1.10** [1.03;1.10]	n.s.		n.s.	n.s.		n.s.	n.s.
Gender	n.s.	n.s.		n.s.	n.s.		.82** [.40;1.72]	n.s.		n.s.	n.s.		n.s.	n.s.
Disease Duration	1.16** [1.08;1.25]	n.s.		1.14** [1.07;1.21]	n.s.		1.13* [1.05;1.21]	n.s.		n.s.	n.s.		n.s.	n.s.
EDSS Score	3.19** [2.20;4.61]	2.86** [1.95;4.18]		4.01** [2.37;6.81]	4.10** [2.36;7.12]		1.94** [1.50;2.50]	1.61* [1.21;2.13]		n.s.	n.s.		n.s.	n.s.
MSFC z-score ^§	.19** [.09;.37]	n.s.		.08** [.03;.23]	n.s.		.31** [.17;.58]	n.s.		n.s.	n.s.		n.s.	n.s.
BDI Score	n.s.	n.s.		n.s.	n.s.		1.10** [1.05;1.15]	n.s.		1.14** [1.07;1.21]	n.s.		1.19** [1.12;1.28]	1.13* [1.04;1.24]
M-FIS Score	1.05** [1.03;1.08]	n.s.		1.04* [1.02;1.07]	n.s.		1.08** [1.05;1.10]	n.s.		1.08** [1.05;1.11]	1.08** [1.05;1.12]		1.06 ** [1.04;1.09]	n.s.
FAMS Score^§	.97** [.96;.99]	n.s.		.98* [.96;.99]	n.s.		.96** [.94;.97]	.96** [.95;.98]		.96** [.95;.98]	n.s.		.96** [.95;.98]	.97* [.05;.99]

^1,2Percentage of people having problems in the EQ-5D subdimensions: comparison between data concerning the general population [26] and the specific MS population in our study, ^§protecting factors, **(p < .001); *(p < .05), n.s. not significant (p > .05).
RRMS Relapsing-Remitting MS; SPMS Secondary Progressive MS; EDSS Extended Disability Symptom Scale, MSFC Multiple Sclerosis Functional Composite; BDI-II Beck Depression Inventory; M-FIS Modified Fatigue Impact Scale; FAMS Functional Assessment of Multiple Sclerosis; Gen. Pop.: General population; Tot.: Total; M: male; F: female.
Uni- and multivariate logistic regression analysis identifying predictors for each EQ-5D subdimension.

ISSN: 1477-7525