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Table 2 Clinical characteristics of patients with multiple sclerosis included in this study and results of EDSS, EQ-5D, FAMS, MSFC, M-FIS, and BDI-II at baseline, 6 months and 12 months follow-up investigation

From: Preference-based Health status in a German outpatient cohort with multiple sclerosis

Variable Baseline 6 months Δ Baseline – 6 M 12 months Δ Baseline – 12 M
  Median (range) Median (range) p-value Median (range) p-value
  Mean ± SD Mean ± SD p-value Mean ± SD p-value
EDSS (N = 55) 3.50 (0–8.5) 3.25 (0–8.0) n.s. 4.0 (0–9.0) <0.001
EuroQol      
  EQ-5D Index Score (N = 56) 0.79 ±0.20 0.79 ±0.19 n.s. 0.78 ±0.23 n.s.
  EQ VAS (N = 51) 59.84 ±20.0 61.82 ±18.7 n.s. 61.37 ±18.4 n.s.
FAMS (N = 56)      
  Sum Score 113.7 ±32.3 115.1 ± 31.6 n.s. 110.3 ± 31.6 n.s.
  Mobility 16.7 ±7.1 16.4 ± 7.0 n.s. 15.7 ± 7.1 n.s.
  Symptoms 20.1 ±5.6 20.3 ± 5.3 n.s. 20.1 ± 5.2 n.s.
  Emotional Well-being 19.3 ±6.2 19.8 ± 6.0 n.s. 18.9 ± 6.1 n.s.
  General Contentment 17.2 ±6.6 17.5 ± 6.2 n.s. 16.8 ± 5.9 n.s.
  Thinking and Fatigue 21.0 ±9.1 21.4 ± 9.2 n.s. 19.3 ± 9.6 n.s.
  Family/ Social Well-being 19.5 ±6.5 19.7 ± 6.5 n.s. 19.5 ± 5.4 n.s.
MSFC (Z-composite) (N = 55) - 0.162 ±0.764 −0.155 ± 0.763 n.s. - 0.120 ±0.985 n.s.
M-FIS Sum Score (N = 52) 37.9 ±18.1 37.4 ±21.4 n.s. 36.1 ±20.6 n.s.
BDI Sum Score (N = 55) 14.4 ±9.8 14.8 ±10.0 n.s. 14.6 ±8.9 n.s.
  % (n) % (n)   % (n)  
  Normal (0–8 pts) 30.9 (17) 32.7 (18)   25.5 (14)  
  Minimal (9–13 pts) 27.3 (15) 21.8 (12)   14.5 (8)  
  Mild (14–19 pts) 20.0 (11) 23.7 (13)   21.8 (12)  
  Medium (20–28 pts) 14.5 (8) 10.9 (6)   32.7 (18)  
  Severe (29–63 pts) 7.3 (4) 10.9 (6)   5.5 (3)  
  1. EDSS Extended Disability Symptom Scale, EQ-5D EuroQoL, EQ VAS Visual Analogue Scale, FAMS Functional Assessment in Multiple Sclerosis, MSFC Multiple Sclerosis Functional Composite, M-FIS Modified Fatigue Impact Scale, BDI-II Beck Depression Inventory.
  2. Changes from baseline to either 6 months or 12 months did not reach statistical significance (p > 0.10, Pillai’s Trace) except for EDSS at 12 months.