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Table 2 Clinical characteristics of patients with multiple sclerosis included in this study and results of EDSS, EQ-5D, FAMS, MSFC, M-FIS, and BDI-II at baseline, 6 months and 12 months follow-up investigation

From: Preference-based Health status in a German outpatient cohort with multiple sclerosis

Variable

Baseline

6 months

Δ Baseline – 6 M

12 months

Δ Baseline – 12 M

 

Median (range)

Median (range)

p-value

Median (range)

p-value

 

Mean ± SD

Mean ± SD

p-value

Mean ± SD

p-value

EDSS (N = 55)

3.50 (0–8.5)

3.25 (0–8.0)

n.s.

4.0 (0–9.0)

<0.001

EuroQol

     

  EQ-5D Index Score (N = 56)

0.79 ±0.20

0.79 ±0.19

n.s.

0.78 ±0.23

n.s.

  EQ VAS (N = 51)

59.84 ±20.0

61.82 ±18.7

n.s.

61.37 ±18.4

n.s.

FAMS (N = 56)

     

  Sum Score

113.7 ±32.3

115.1 ± 31.6

n.s.

110.3 ± 31.6

n.s.

  Mobility

16.7 ±7.1

16.4 ± 7.0

n.s.

15.7 ± 7.1

n.s.

  Symptoms

20.1 ±5.6

20.3 ± 5.3

n.s.

20.1 ± 5.2

n.s.

  Emotional Well-being

19.3 ±6.2

19.8 ± 6.0

n.s.

18.9 ± 6.1

n.s.

  General Contentment

17.2 ±6.6

17.5 ± 6.2

n.s.

16.8 ± 5.9

n.s.

  Thinking and Fatigue

21.0 ±9.1

21.4 ± 9.2

n.s.

19.3 ± 9.6

n.s.

  Family/ Social Well-being

19.5 ±6.5

19.7 ± 6.5

n.s.

19.5 ± 5.4

n.s.

MSFC (Z-composite) (N = 55)

- 0.162 ±0.764

−0.155 ± 0.763

n.s.

- 0.120 ±0.985

n.s.

M-FIS Sum Score (N = 52)

37.9 ±18.1

37.4 ±21.4

n.s.

36.1 ±20.6

n.s.

BDI Sum Score (N = 55)

14.4 ±9.8

14.8 ±10.0

n.s.

14.6 ±8.9

n.s.

 

% (n)

% (n)

 

% (n)

 

  Normal (0–8 pts)

30.9 (17)

32.7 (18)

 

25.5 (14)

 

  Minimal (9–13 pts)

27.3 (15)

21.8 (12)

 

14.5 (8)

 

  Mild (14–19 pts)

20.0 (11)

23.7 (13)

 

21.8 (12)

 

  Medium (20–28 pts)

14.5 (8)

10.9 (6)

 

32.7 (18)

 

  Severe (29–63 pts)

7.3 (4)

10.9 (6)

 

5.5 (3)

 
  1. EDSS Extended Disability Symptom Scale, EQ-5D EuroQoL, EQ VAS Visual Analogue Scale, FAMS Functional Assessment in Multiple Sclerosis, MSFC Multiple Sclerosis Functional Composite, M-FIS Modified Fatigue Impact Scale, BDI-II Beck Depression Inventory.
  2. Changes from baseline to either 6 months or 12 months did not reach statistical significance (p > 0.10, Pillai’s Trace) except for EDSS at 12 months.