Figure 1

Change in MacNew scores. (t0: baseline; t1: 1 month; t2: 6 months; t3: 12 months, t4: 24 months). Boxes show median and quartiles, whiskers maximum within 1.5 interquartile range, dots outliers outside 1.5 interquartile range and stars outliers outside 3.0 interquartile range. Horizontal lines at 0.5 and −0.5 designate the range of clinical important change (≥0.5) in MacNew Global score.