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Table 1 Studies on the economic burden associated with incontinence

From: Health-related quality of life and economic impact of urinary incontinence due to detrusor overactivity associated with a neurologic condition: a systematic review

Citation; CEBM Evidence grade [9]

Study design/methodology

Cost data source

Country

Populations

Frantz et al. 2003 [39]; 2

Secondary data analysis

Medical records

US

Residents of long-term care facility

• N = 63

• Mean age 87 ± 7 yr

• 77% were female

• 54% were incontinent

Green et al. 2003 [34]; 3

Retrospective analysis

Registry

Australia

6773 episodes of care provided to 6455 rehabilitation and geriatric evaluation and management patients

New Zealand

Irwin et al. 2008 [36]; 3

Economic cost of illness model; included costs for 2002 ICS-defined OAB and urgency UI-related comorbidities and nursing home costs

Economic model

Canada

EPIC survey population with OAB or urgent UI

Germany

Italy

• Aged 18+ yr

Spain

Sweden

UK

Morris et al. 2005 [33]; 3

Prospective burden of illness study

Prospective chart data

Australia

Incontinent patients

• Mean age 85 (range 74–91) yr

Papanicolaou et al. 2005 [35]; 3

Prospective urinary incontinence research (PURE) is a non-interventional, longitudinal, prospective, observational, multicentre, multinational study to determine the direct cost for patients with UI

Prospective survey data

Germany

Patients with UI

Spain

• Germany: n = 2696, mean age 65.1 ± 13.4 yr

UK/Ireland

• Spain: n = 2127, mean age 57.9 ± 12.7 yr

• UK/Ireland: n = 1070, mean age 60.1 ± 14.3 yr

Prasopsanti et al. 2007 [41]; 3

Economic model using diagnostic and treatment algorithms from clinical practice guidelines and current disease prevalence data

Economic model

Thailand

Patients with UI (prevalence estimates used in model derived from elsewhere)

Shih et al. 2003 [40]; 3

Prospective study

Prospective survey data

US

Patients with UI in long-term care facilities

Subak et al. 2006 [42]; 3

Cross-sectional study

Prospective survey data

US

Women with UI

• N = 293

• Mean age 56 ±11 yr

Tediosi et al. 2000 [37]; 3

Cross-sectional study/home interview with costs quantified for stress UI and other types of UI separately

Interview data and retrospective database (Italian National Health Service tariffs)

Italy

Women with UI

• N = 229

Age >40 yr

Thom et al. 2005 [38]; 3

Database study

Retrospective database

US

Women with UI

• N = N/A (combination of large public and private population data sources, including CMS, MEPS, NHANES, NCHS, VA, NACHRI, and MarketScan)

• Age >60 yr

Wefer et al. 2010 [15]; 2

Multicentre, cross-sectional, retrospective cohort study

Retrospective chart review

Germany

Neurological disorders:

SCI, 80.8%

MS, 5.2%

Spina bifida, 14.0%

• N = 214

    

• Mean age 38 (14.8) yr

  1. UI = urinary incontinence; OAB = overactive bladder; CEBM = Oxford Centre for Evidence-Based Medicine; CMS = Centers for Medicare and Medicaid Services; MEPS = Medical Expenditure Panel Survey; NHANES = National Health and Nutrition Examination Survey; VA = Department of Veterans Affairs; NACHRI = National Association of Children’s Hospitals and Related Institutions.