| |
Baseline
|
Month 6
|
Month 12
|
Month 18
|
Month 24
|
|---|
|
MusiQoL
|
M (SD)
|
M (SD)
|
D
M6-BL
|
ES
|
M (SD)
|
D
M12-BL
|
ES
|
M (SD)
|
D
M18-BL
|
ES
|
M (SD)
|
D
M24-BL
|
ES
|
|---|
|
ADL
|
50.0 (24.4)
|
46.9 (25.2)
|
−3.33
|
−0.14
|
49.4 (26.1)
|
−1.04
|
−0.04
|
47.1 (26.9)
|
−3.04
|
−0.12
|
46.8 (28.2)
|
−3.53
|
−0.14
|
|
PWB
|
62.6 (22.1)
|
62.5 (23.0)
|
−0.56
|
−0.02
|
64.8 (22.5)
|
2.04
|
0.09
|
61.7 (23.2)
|
−1.33
|
−0.06
|
64.3 (23.9)
|
1.67
|
0.08
|
|
SPT
|
64.7 (21.3)
|
68.1 (21.6)
|
3.54*
|
0.16
|
69.2 (20.4)
|
4.29**
|
0.20
|
65.3 (21.6)
|
0.22
|
0.07
|
67.2 (21.3)
|
2.16
|
0.10
|
|
RFr
|
62.2 (25.0)
|
59.3 (24.6)
|
−2.72
|
−0.11
|
60.3 (24.0)
|
−1.33
|
−0.05
|
64.4 (23.4)
|
1.55
|
0.06
|
60.3 (23.6)
|
−1.67
|
−0.07
|
|
RFa
|
74.6 (22.5)
|
73.2 (21.9)
|
−1.35
|
−0.06
|
69.7 (25.3)
|
−4.46
|
−0.20
|
73.4 (23.0)
|
−1.83
|
−0.08
|
72.6 (23.2)
|
−2.17
|
−0.10
|
|
SSL
|
63.3 (29.4)
|
59.5 (28.7)
|
−3.65
|
−0.12
|
57.7 (29.3)
|
−4.89*
|
−0.16
|
54.3 (30.5)
|
−9.62***
|
−0.32
|
56.1 (30.6)
|
−6.38*
|
−0.21
|
|
COP
|
66.1 (27.0)
|
66.7 (26.1)
|
0.36
|
0.01
|
67.2 (26.1)
|
0.12
|
0.00
|
67.3 (27.2)
|
1.14
|
0.04
|
64.5 (28.6)
|
−0.73
|
−0.03
|
|
REJ
|
78.7 (27.7)
|
78.1 (24.4)
|
−0.36
|
−0.01
|
79.4 (23.8)
|
0.61
|
0.02
|
78.1 (24.8)
|
−0.38
|
−0.01
|
78.2 (24.8)
|
−0.12
|
−0.00
|
|
RHCS
|
86.8 (14.8)
|
82.6 (19.1)
|
−4.49**
|
−0.30
|
82.9 (17.2)
|
−3.96**
|
−0.
27
|
81.9 (20.4)
|
−4.93**
|
−0.
33
|
80.7 (19.7)
|
−5.98***
|
−0
.40
|
|
Index
|
67.0 (13.1)
|
65.8 (13.9)
|
−1.12
|
−0.09
|
66.1 (13.1)
|
−1.08
|
−0.08
|
65.7 (13.8)
|
−2.46**
|
−0.19
|
65.2 (15.0)
|
−2.26
|
−0.17
|
|
SF-36v2
|
M (SD)
|
M (SD)
|
D
M6-BL
|
ES
|
M (SD)
|
D
M12-BL
|
ES
|
M (SD)
|
D
M18-BL
|
ES
|
M (SD)
|
D
M24-BL
|
ES
|
|
PF
|
48.4 (28.5)
|
45.2 (29.0)
|
−2.95
|
−0.10
|
46.6 (29.8)
|
−2.19
|
−0.08
|
42.9 (30.4)
|
−5.37**
|
−0.19
|
41.1 (32.0)
|
−7.84***
|
−0.
28
|
|
RP
|
50.4 (27.9)
|
50.3 (28.8)
|
−0.04
|
−0.00
|
50.9 (28.1)
|
−0.55
|
−0.02
|
45.1 (27.8)
|
−4.60
|
−0.17
|
46.0 (29.8)
|
−4.83*
|
−0.17
|
|
BP
|
67.6 (26.3)
|
64.1 (26.7)
|
−3.88
|
−0.15
|
64.1 (25.7)
|
−3.10
|
−0.12
|
61.6 (28.2)
|
−5.88**
|
−0.
22
|
60.9 (27.3)
|
−7.44***
|
−0.
28
|
|
GH
|
49.5 (21.2)
|
50.2 (18.8)
|
0.89
|
0.04
|
47.4 (20.1)
|
−2.83
|
−0.13
|
49.3 (20.0)
|
−0.59
|
−0.03
|
47.9 (21.4)
|
−2.27
|
−0.11
|
|
Vi
|
43.5 (18.3)
|
45.7 (20.2)
|
2.08
|
0.11
|
44.6 (19.6)
|
1.04
|
0.06
|
43.1 (19.4)
|
−0.58
|
−0.03
|
44.1 (20.3)
|
0.58
|
0.03
|
|
SF
|
65.8 (24.1)
|
64.9 (25.5)
|
−1.09
|
−0.04
|
65.3 (27.4)
|
−0.25
|
−0.01
|
65.0 (25.5)
|
−0.98
|
−0.04
|
61.9 (28.7)
|
−3.85
|
−0.16
|
|
RE
|
53.0 (14.9)
|
54.8 (12.5)
|
1.29
|
−0.09
|
52.5 (13.3)
|
−0.59
|
−0.04
|
52.8 (13.7)
|
−0.80
|
−0.05
|
51.7 (14.4)
|
−1.94
|
−0.13
|
|
MH
|
65.4 (18.7)
|
66.8 (18.0)
|
0.98
|
0.05
|
64.6 (20.5)
|
−1.04
|
−0.06
|
64.3 (18.2)
|
−1.85
|
−0.10
|
63.2 (20.4)
|
−3.12
|
−0.17
|
|
PCS
|
39.6 (9.9)
|
38.1 (9.8)
|
−1.19
|
−0.12
|
38.9 (9.5)
|
−0.93
|
−0.09
|
37.4 (10.6)
|
−2.13**
|
−0.
22
|
37.3 (11.1)
|
−2.59***
|
−0.
26
|
|
MCS
|
44.9 (8.6)
|
46.2 (8.5)
|
1.30
|
0.15
|
45.1 (8.6)
|
0.50
|
0.06
|
45.1 (8.1)
|
0.16
|
0.02
|
45.1 (8.9)
|
−0.11
|
−0.01
|
- MusiQoL Multiple Sclerosis Quality of Life questionnaire.
- ADL activity of daily living, PWB psychological well-being, SPT symptoms, RFr relationships with friends, RFa relationships with family, SSL sentimental and sexual life, COP coping, REJ rejection, RHCS relationships with health care system.
- SF-36v2 Short Form 36 version 2.
- PF physical functioning, RP role physical, BP bodily pain, GH general health, Vi vitality, SF social functioning, RE role-emotional, MH mental health, PCS physical component summary, MCS mental component summary.
- M (SD), mean (standard deviation).
- DMi-BL: difference mean between the score of the evaluation time and the baseline score (a positive difference indicates a QoL improvement and a negative difference indicates a QoL deterioration), *p < =0.05, **p < =0.01, ***p < =0.001.
- ES, effect size; bold values indicate effect sizes > = 0.20.
