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Table 2 Responsiveness of MusiQoL and SF-36 in the 107 worsened patients

From: Responsiveness of the Multiple Sclerosis International Quality of Life questionnaire to disability change: a longitudinal study

  Baseline Month 6 Month 12 Month 18 Month 24
MusiQoL M (SD) M (SD) D M6-BL ES M (SD) D M12-BL ES M (SD) D M18-BL ES M (SD) D M24-BL ES
ADL 50.0 (24.4) 46.9 (25.2) −3.33 −0.14 49.4 (26.1) −1.04 −0.04 47.1 (26.9) −3.04 −0.12 46.8 (28.2) −3.53 −0.14
PWB 62.6 (22.1) 62.5 (23.0) −0.56 −0.02 64.8 (22.5) 2.04 0.09 61.7 (23.2) −1.33 −0.06 64.3 (23.9) 1.67 0.08
SPT 64.7 (21.3) 68.1 (21.6) 3.54* 0.16 69.2 (20.4) 4.29** 0.20 65.3 (21.6) 0.22 0.07 67.2 (21.3) 2.16 0.10
RFr 62.2 (25.0) 59.3 (24.6) −2.72 −0.11 60.3 (24.0) −1.33 −0.05 64.4 (23.4) 1.55 0.06 60.3 (23.6) −1.67 −0.07
RFa 74.6 (22.5) 73.2 (21.9) −1.35 −0.06 69.7 (25.3) −4.46 −0.20 73.4 (23.0) −1.83 −0.08 72.6 (23.2) −2.17 −0.10
SSL 63.3 (29.4) 59.5 (28.7) −3.65 −0.12 57.7 (29.3) −4.89* −0.16 54.3 (30.5) −9.62*** −0.32 56.1 (30.6) −6.38* −0.21
COP 66.1 (27.0) 66.7 (26.1) 0.36 0.01 67.2 (26.1) 0.12 0.00 67.3 (27.2) 1.14 0.04 64.5 (28.6) −0.73 −0.03
REJ 78.7 (27.7) 78.1 (24.4) −0.36 −0.01 79.4 (23.8) 0.61 0.02 78.1 (24.8) −0.38 −0.01 78.2 (24.8) −0.12 −0.00
RHCS 86.8 (14.8) 82.6 (19.1) −4.49** −0.30 82.9 (17.2) −3.96** −0. 27 81.9 (20.4) −4.93** −0. 33 80.7 (19.7) −5.98*** −0 .40
Index 67.0 (13.1) 65.8 (13.9) −1.12 −0.09 66.1 (13.1) −1.08 −0.08 65.7 (13.8) −2.46** −0.19 65.2 (15.0) −2.26 −0.17
SF-36v2 M (SD) M (SD) D M6-BL ES M (SD) D M12-BL ES M (SD) D M18-BL ES M (SD) D M24-BL ES
PF 48.4 (28.5) 45.2 (29.0) −2.95 −0.10 46.6 (29.8) −2.19 −0.08 42.9 (30.4) −5.37** −0.19 41.1 (32.0) −7.84*** −0. 28
RP 50.4 (27.9) 50.3 (28.8) −0.04 −0.00 50.9 (28.1) −0.55 −0.02 45.1 (27.8) −4.60 −0.17 46.0 (29.8) −4.83* −0.17
BP 67.6 (26.3) 64.1 (26.7) −3.88 −0.15 64.1 (25.7) −3.10 −0.12 61.6 (28.2) −5.88** −0. 22 60.9 (27.3) −7.44*** −0. 28
GH 49.5 (21.2) 50.2 (18.8) 0.89 0.04 47.4 (20.1) −2.83 −0.13 49.3 (20.0) −0.59 −0.03 47.9 (21.4) −2.27 −0.11
Vi 43.5 (18.3) 45.7 (20.2) 2.08 0.11 44.6 (19.6) 1.04 0.06 43.1 (19.4) −0.58 −0.03 44.1 (20.3) 0.58 0.03
SF 65.8 (24.1) 64.9 (25.5) −1.09 −0.04 65.3 (27.4) −0.25 −0.01 65.0 (25.5) −0.98 −0.04 61.9 (28.7) −3.85 −0.16
RE 53.0 (14.9) 54.8 (12.5) 1.29 −0.09 52.5 (13.3) −0.59 −0.04 52.8 (13.7) −0.80 −0.05 51.7 (14.4) −1.94 −0.13
MH 65.4 (18.7) 66.8 (18.0) 0.98 0.05 64.6 (20.5) −1.04 −0.06 64.3 (18.2) −1.85 −0.10 63.2 (20.4) −3.12 −0.17
PCS 39.6 (9.9) 38.1 (9.8) −1.19 −0.12 38.9 (9.5) −0.93 −0.09 37.4 (10.6) −2.13** −0. 22 37.3 (11.1) −2.59*** −0. 26
MCS 44.9 (8.6) 46.2 (8.5) 1.30 0.15 45.1 (8.6) 0.50 0.06 45.1 (8.1) 0.16 0.02 45.1 (8.9) −0.11 −0.01
  1. MusiQoL Multiple Sclerosis Quality of Life questionnaire.
  2. ADL activity of daily living, PWB psychological well-being, SPT symptoms, RFr relationships with friends, RFa relationships with family, SSL sentimental and sexual life, COP coping, REJ rejection, RHCS relationships with health care system.
  3. SF-36v2 Short Form 36 version 2.
  4. PF physical functioning, RP role physical, BP bodily pain, GH general health, Vi vitality, SF social functioning, RE role-emotional, MH mental health, PCS physical component summary, MCS mental component summary.
  5. M (SD), mean (standard deviation).
  6. DMi-BL: difference mean between the score of the evaluation time and the baseline score (a positive difference indicates a QoL improvement and a negative difference indicates a QoL deterioration), *p < =0.05, **p < =0.01, ***p < =0.001.
  7. ES, effect size; bold values indicate effect sizes > = 0.20.