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Table 5 Responsiveness from baseline to week 54

From: Psychometric validation of the visual function questionnaire-25 in patients with diabetic macular edema

  Group: Patients with a > = 5 letter improvement on the ETDRS in their study eye between baseline and week 54
  VFQ-25 Change Score    Guyatt’s Responsiveness
VFQ-25 Domain n Mean P value from one-sample t-test Effect Size* SRM n Statistic
1. General Health 93 3.23 .14 0.15 0.15 30 0.12
2. General Vision 93 10.32 <.001 0.55 0.56 30 0.57
3. Ocular Pain 93 2.96 .16 0.13 0.15 30 0.14
4. Near Activities 93 5.69 .011 0.23 0.27 30 0.29
5. Distance Activities 93 3.67 .12 0.15 0.16 30 0.21
6. Social Functioning 93 0.54 .75 0.02 0.03 30 0.02
7. Mental Health 93 4.64 .024 0.17 0.24 30 0.21
8. Role Difficulties 93 11.29 <.001 0.41 0.38 30 0.49
9. Dependency 93 2.78 .25 0.09 0.12 30 0.10
10. Driving 56 5.73 .018 0.16 0.33 17 0.25
11. Colour Vision 91 1.92 .35 0.09 0.10 30 0.09
12. Peripheral Vision 93 4.30 .070 0.17 0.19 30 0.19
VFQ-25 Composite 93 4.90 <.001 0.26 0.43 30 0.39
  1. * Effect size: the mean change score divided by the standard deviation of the baseline score.
  2. † Standardized response mean: the mean change score divided by the standard deviation of the change score.
  3. ‡ Guyatt's responsiveness statistic: the mean change score divided by the standard deviation of change in subjects who remained stable. Stable groups are defined as an increase or a decrease of up to 1 letter.