Beliefs about chelation among thalassemia patients

Trachtenberg, Felicia L; Mednick, Lauren; Kwiatkowski, Janet L; Neufeld, Ellis J; Haines, Dru; Pakbaz, Zahra; Thompson, Alexis A; Quinn, Charles T; Grady, Robert; Sobota, Amy; Olivieri, Nancy; Horne, Robert; Yamashita, Robert

doi:10.1186/1477-7525-10-148

Health and Quality of Life Outcomes

Table 4 Correlations of Beliefs in Medicines Questionnaire (BMQ) scale responses to quality of life and chelation adherence

From: Beliefs about chelation among thalassemia patients

	DFO			Oral Chelator			Iron Burden
	Specific Necessity	Specific Concerns	Adherence^f	Specific Necessity	Specific Concerns	Adherence^f	Ferritinx^g	LIC^g
General Overuse	0.04 (p=0.66)	0.29 (p<0.001)	−0.09 (p=0.30)	−0.13 (p=0.04)	0.32 (p<0.001)	−0.11 (p=0.10)	0.10 (p=0.06)	0.13 (p=0.04)
General Harm	0.01 (p=0.95)	0.42 (p<0.001)	−0.11 (p=0.23)	−0.13 (p=0.03)	0.35 (p<0.001)	−0.12 (p=0.07)	0.12 (p=0.02)	0.21 (p<0.001)
General Benefit	0.30 (p<0.001)	0.04 (p=0.64)	0.19 (p=0.03)	0.37 (p<0.001)	−0.05 (p=0.46)	−0.002 (p=0.97)	0.02 (p=0.73)	0.03 (p=0.64)
Sensitive Soma	−0.02 (p=0.79)	0.17 (p=0.05)	−0.23 (p=0.01)	−0.09 (p=0.14)	0.35 (p<0.001)	−0.09 (p=0.15)	0.01 (p=0.89)	0.01 (p=0.82)
Coping w/o Treatment^a	−0.27 (p=0.002)	−0.001 (p=0.98)	0.01 (p=0.95)	−0.44 (p<0.001)	0.16 (p=0.01)	−0.12 (p=0.08)	NA	NA
Side Effects^b	−0.16 (p=0.06)	0.50 (p<0.001)	−0.11 (p=0.23)	−0.03 (p=0.65)	0.46 (p<0.001)	−0.14 (p=0.04)	NA	NA
QOL Physical – adults^c	−0.11 (p=0.26)	−0.16 (p=0.11)	NA	−0.06 (p=0.45)	−0.19 (p=0.008)	NA	NA	NA
QOL Mental – adults^c	0.06 (p=0.55)	−0.10 (p=0.31)	NA	−0.11 (p=0.14)	−0.23 (p=0.001)	NA	NA	NA
QOL Physical – children^d	0.26 (p=0.19)	−0.04 (p=0.83)	NA	−0.01 (p=0.95)	−0.34 (p=0.006)	NA	NA	NA
QOL Mental – children^d	0.04 (p=0.85)	−0.49 (p=0.01)	NA	0.09 (p=0.50)	−0.38 (p=0.002)	NA	NA	NA
Anxiety^e	0.02 (p=0.82)	0.19 (p=0.06)	NA	0.04 (p=0.58)	0.29 (p<0.001)	NA	NA	NA
Depression^e	0.07 (p=0.46)	0.34 (p<0.001)	NA	0.04 (p=0.59)	0.28 (p<0.001)	NA	NA	NA
Chelation Adherence^f	−0.10 (p=0.28)	−0.01 (p=0.91)	NA	0.03 (p=0.63)	−0.09 (p=0.18)	NA	NA	NA
Ferritin^g	0.12 (p=0.17)	−0.21^h (p=0.02)	−0.28 (p=0.002)	−0.06 (p=0.39)	0.14 (p=0.03)	−0.25 (p<0.001)	NA	NA
LIC^g	−0.04 (p=0.66)	−0.06 (p=0.56)	−0.09 (p=0.39)	−0.04 (p=0.57)	0.14 (p=0.06)	−0.22 (p=0.004)	NA	NA

^a single item asking how well patients can cope without their chelation (1–5 scale).
^b single item asking about unpleasant side effects of chelation (1–5 scale).
^c Physical and Mental Component Summary scales of the SF-36v2 quality of life (QOL) health survey, completed by participants aged 14 and older. Higher scores indicate higher QOL.
^d Physical Summary and Psychosocial Summary scales of the PF-28 child health questionnaire (CHQ) , completed by parents/guardians of participants <14 years of age. Higher scores indicate higher QOL.
^e Anxiety and depressions scales of the Hospital Anxiety and Depression Scale (HADS), completed by participants aged 14 and older. Higher scores indicate increased anxiety/depression.
^f Self-reported (or parent-reported) percent of prescribed doses taken in the last 4 weeks.
^g Serum ferritin and Liver iron concentration (LIC) averaged over past year, log-transformed due to skew.
^h not significant in adults (r=−0.10, p=0.38).

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ISSN: 1477-7525

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