Brief assessment of priority symptoms in hormone refractory prostate cancer: The FACT Advanced Prostate Symptom Index (FAPSI)

Table 7 Guyatt's Responsiveness Statistics for FAPSI-6 and FAPSI-8

Instrument	Average change¹ score of observations with worse² PSR	Average change¹ score of observations with same² PSR	Mean Square Error³	Guyatt's Responsiveness Statistic⁴
EORTC QLQ-C30 Global Score	-17.47	-3.49	136.96	0.85
FACT-G Total Score	-8.56	-0.63	37.16	0.92
FACT-P Total Score	-13.98	-1.43	69.58	1.06
Trial Outcome Index (TOI)	-13.80	-2.01	39.62	1.33
FACT Advanced Prostate Symptom Index-6 (FAPSI-6)	-4.40	-0.29	4.15	1.42
FACT Advanced Prostate Symptom Index-8 (FAPSI-8)	-4.62	-0.11	6.12	1.29

¹Average change score = average score change from baseline and weeks 6, 12 and 24 ²Worse PSR and same PSR = PSR at weeks 6, 12 and 24 compared to baseline ³Mean squared error of observed score obtained from ANOVA model examining repeated observations of measure in clinically stable subjects ⁴Average change score of observations with worse PSR – average change score of observations with same PSR)/sqrt (2*MSE)

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