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Table 7 Guyatt's Responsiveness Statistics for FAPSI-6 and FAPSI-8

From: Brief assessment of priority symptoms in hormone refractory prostate cancer: The FACT Advanced Prostate Symptom Index (FAPSI)

Instrument Average change1 score of observations with worse2 PSR Average change1 score of observations with same2 PSR Mean Square Error3 Guyatt's Responsiveness Statistic4
EORTC QLQ-C30 Global Score -17.47 -3.49 136.96 0.85
FACT-G Total Score -8.56 -0.63 37.16 0.92
FACT-P Total Score -13.98 -1.43 69.58 1.06
Trial Outcome Index (TOI) -13.80 -2.01 39.62 1.33
FACT Advanced Prostate Symptom Index-6 (FAPSI-6) -4.40 -0.29 4.15 1.42
FACT Advanced Prostate Symptom Index-8 (FAPSI-8) -4.62 -0.11 6.12 1.29
  1. 1Average change score = average score change from baseline and weeks 6, 12 and 24 2Worse PSR and same PSR = PSR at weeks 6, 12 and 24 compared to baseline 3Mean squared error of observed score obtained from ANOVA model examining repeated observations of measure in clinically stable subjects 4Average change score of observations with worse PSR – average change score of observations with same PSR)/sqrt (2*MSE)