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Table 6 Analyses of Variance of Patient Reported Outcome Measures Among Three Groups of PASI Improvement Scores:≥ 75%; Between 50% and 75%; and < 50%.

From: Validity and reliability of patient reported outcomes used in Psoriasis: results from two randomized clinical trials

  STUDY A STUDY B
  Mean Change Score (N)   Mean Change Score (N)    
Outcome Measure <50% ≥50% and <75% ≥75% F statistic p value < 50% ≥50% and <75% ≥75% F statistic p value
PSA Frequency (8 items) 2.38 (232) 6.48 (97) 8.75 (110) 61.71 <0.0001 2.35 (269) 7.16 (149) 9.71 (125) 85.65 <0.0001
PSA Frequency (7 items) 1.90 (232) 5.15 (97) 7.12 (111) 49.81 <0.0001 1.90 (269) 5.94 (149) 7.98 (125) 72.61 <0.0001
PSA Severity (8 items) 2.45 (231) 7.05 (97) 9.93 (111) 69.06 <0.0001 2.52 (271) 7.87 (149) 10.52 (125) 88.46 <0.0001
PSA Severity (7 items) 1.95 (231) 5.76 (97) 8.19 (111) 58.82 <0.0001 2.05 (271) 6.47 (149) 8.79 (125) 77.04 <0.0001
PSA TOTAL Scale (16 items) 4.79 (230) 13.53 (96) 18.63 (110) 69.76 <0.0001 4.88 (269) 15.03 (149) 20.23 (125) 91.77 <0.0001
DLQI TOTAL 2.48 (223) 5.33 (97) 9.57 (104) 54.61 <0.0001 2.49 (268) 6.83 (146) 10.03 (122) 75.05 <0.0001
   DLQI Symptom and Feelings 0.74 (235) 1.70 (98) 2.94 (110) 69.64 <0.0001 0.79 (271) 2.14 (150) 2.95 (127) 94.27 <0.0001
   DLQI Daily Activities 0.45 (234) 1.13 (98) 2.14 (110) 41.11 <0.0001 0.61 (270) 1.47 (150) 2.17 (127) 42.37 <0.0001
   DLQI Leisure 0.40 (235) 0.96 (98) 1.81 (111) 27.70 <0.0001 0.60 (271) 1.08 (150) 1.89 (126) 22.34 <0.0001
   DLQI Work and School 0.28 (226) 0.46 (97) 0.62 (106) 5.41a <0.0001 0.17 (269) 0.52 (147) 0.73 (123) 16.44b <0.0001
   DLQI Personal Relationships 0.20 (236) 0.45 (98) 1.20 (111) 17.89 <0.0001 0.12 (271) 0.75 (150) 1.21 (126) 25.21 <0.0001
   DLQI Treatment 0.22 (236) 0.65 (98) 1.05 (111) 24.90 <0.0001 0.14 (271) 0.81 (149) 1.08 (126) 41.70b <0.0001
NPF Itch Scale n/a n/a n/a n/a n/a 0.59 (273) 1.65 (150) 2.34 (127) 58.13 <0.0001
VAS Itch Scale 0.79 (235) 2.97 (98) 4.34 (111) 56.96 <0.0001 n/a n/a n/a n/a n/a
  1. Note: Post-hoc comparisons of groups indicate all groups differ from one another for each of the measures, p < .05, unless otherwise specified. a PASI change ≥75% different from PASI change <50% only. b PASI change ≥75% not significantly different from middle group (PASI change ≥50% and <75%.