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Table 6 Analyses of Variance of Patient Reported Outcome Measures Among Three Groups of PASI Improvement Scores:≥ 75%; Between 50% and 75%; and < 50%.

From: Validity and reliability of patient reported outcomes used in Psoriasis: results from two randomized clinical trials

 

STUDY A

STUDY B

 

Mean Change Score (N)

 

Mean Change Score (N)

   

Outcome Measure

<50%

≥50% and <75%

≥75%

F statistic

p value

< 50%

≥50% and <75%

≥75%

F statistic

p value

PSA Frequency (8 items)

2.38 (232)

6.48 (97)

8.75 (110)

61.71

<0.0001

2.35 (269)

7.16 (149)

9.71 (125)

85.65

<0.0001

PSA Frequency (7 items)

1.90 (232)

5.15 (97)

7.12 (111)

49.81

<0.0001

1.90 (269)

5.94 (149)

7.98 (125)

72.61

<0.0001

PSA Severity (8 items)

2.45 (231)

7.05 (97)

9.93 (111)

69.06

<0.0001

2.52 (271)

7.87 (149)

10.52 (125)

88.46

<0.0001

PSA Severity (7 items)

1.95 (231)

5.76 (97)

8.19 (111)

58.82

<0.0001

2.05 (271)

6.47 (149)

8.79 (125)

77.04

<0.0001

PSA TOTAL Scale (16 items)

4.79 (230)

13.53 (96)

18.63 (110)

69.76

<0.0001

4.88 (269)

15.03 (149)

20.23 (125)

91.77

<0.0001

DLQI TOTAL

2.48 (223)

5.33 (97)

9.57 (104)

54.61

<0.0001

2.49 (268)

6.83 (146)

10.03 (122)

75.05

<0.0001

   DLQI Symptom and Feelings

0.74 (235)

1.70 (98)

2.94 (110)

69.64

<0.0001

0.79 (271)

2.14 (150)

2.95 (127)

94.27

<0.0001

   DLQI Daily Activities

0.45 (234)

1.13 (98)

2.14 (110)

41.11

<0.0001

0.61 (270)

1.47 (150)

2.17 (127)

42.37

<0.0001

   DLQI Leisure

0.40 (235)

0.96 (98)

1.81 (111)

27.70

<0.0001

0.60 (271)

1.08 (150)

1.89 (126)

22.34

<0.0001

   DLQI Work and School

0.28 (226)

0.46 (97)

0.62 (106)

5.41a

<0.0001

0.17 (269)

0.52 (147)

0.73 (123)

16.44b

<0.0001

   DLQI Personal Relationships

0.20 (236)

0.45 (98)

1.20 (111)

17.89

<0.0001

0.12 (271)

0.75 (150)

1.21 (126)

25.21

<0.0001

   DLQI Treatment

0.22 (236)

0.65 (98)

1.05 (111)

24.90

<0.0001

0.14 (271)

0.81 (149)

1.08 (126)

41.70b

<0.0001

NPF Itch Scale

n/a

n/a

n/a

n/a

n/a

0.59 (273)

1.65 (150)

2.34 (127)

58.13

<0.0001

VAS Itch Scale

0.79 (235)

2.97 (98)

4.34 (111)

56.96

<0.0001

n/a

n/a

n/a

n/a

n/a

  1. Note: Post-hoc comparisons of groups indicate all groups differ from one another for each of the measures, p < .05, unless otherwise specified. a PASI change ≥75% different from PASI change <50% only. b PASI change ≥75% not significantly different from middle group (PASI change ≥50% and <75%.