Association of physical fitness with health-related quality of life in Finnish young men
© Häkkinen et al; licensee BioMed Central Ltd. 2010
Received: 8 July 2009
Accepted: 29 January 2010
Published: 29 January 2010
Currently, there is insufficient evidence available regarding the relationship between level of physical fitness and health-related quality of life (HRQoL) in younger adults. Therefore, the aim of the present study was to investigate the impact of measured cardiovascular and musculoskeletal physical fitness level on HRQoL in Finnish young men.
In a cross-sectional study, we collected data regarding the physical fitness index, including aerobic endurance and muscle fitness, leisure-time physical activity (LTPA), body composition, health, and HRQoL (RAND 36) for 727 men [mean (SD) age 25 (5) years]. Associations between HRQoL and the explanatory parameters were analyzed using the logistic regression analysis model.
Of the 727 participants who took part in the study, 45% were in the poor category of the physical fitness, while 37% and 18% were in the satisfactory and good fitness categories, respectively. A higher frequency of LTPA was associated with higher fitness (p < 0.001). Better HRQoL in terms of general health, physical functioning, mental health, and vitality were associated with better physical fitness. When the HRQoL of the study participants were compared with that of the age- and gender-weighted Finnish general population, both the good and satisfactory fitness groups had higher HRQoL in all areas other than bodily pain. In a regression analysis, higher LTPA was associated with three dimensions of HRQoL, higher physical fitness with two, and lower number of morbidities with all dimensions, while the effect of age was contradictory.
Our study of Finnish young men indicates that higher physical fitness and leisure-time physical activity level promotes certain dimensions of HRQoL, while morbidities impair them all. The results highlight the importance of health related physical fitness while promoting HRQoL.
The sedentary lifestyle presents a major public health challenge that must be met in order to prevent obesity and thus enhance health and well-being . For substantial health benefits, current guidelines for adults recommend at least 2.5 hours of moderate-intensity or 1.25 hours of vigorous-intensity aerobic physical activity per week. Futher, moderate- or high-intensity muscle-strengthening activities for all major muscle groups two or more days a week provide additional health benefits . According to the 2005 Eurobarometer on Health and Food, 41% of adults in EU-15 countries reported no moderate level physical activity in the past week and over half (59%) of the EU population get little or no physical activity at work . The decrease in occupational and commuting physical activities should be compensated by an increase in LTPA as there is strong evidence regarding the protective effects of regular LTPA and a high level of physical fitness against major chronic diseases such as coronary heart disease, hypertension, stroke, noninsulin-dependent diabetes mellitus, osteoporosis, depression, and anxiety among others [4–7].
A systematic review has reported a consistent association of higher health-related quality of life (HRQoL) scores with higher PA levels among healthy adults . Physical activity has enhanced well-being and increasing physical functioning also in people with poor health  or of advanced age . Also higher physical fitness level has been shown to be associated with higher levels of HRQoL in the older and chronically diseased populations [10–12]. However, there is insufficient evidence regarding the relationship between physical fitness level and HRQoL in younger adults. One recent study has reported associations between cardiorespiratory fitness and HRQoL in young males in United States navy. They found a positive relationship between submaximal fitness test and mental and physical components of HRQoL . There is still limited evidence on relationships of objectively measured fitness and individual domains of HRQoL. Therefore, the aim of the present study was to investigate the impact of measured cardiovascular and musculoskeletal physical fitness level on HRQoL in Finnish young men.
The study participants were enrolled from April 2008 to November 2008 during eighth refresher course organized in different counties around the country; thus, they geographically represent the entire country. Of 1,155 invited reservists, 922 participated in the courses and 845 men volunteered for the present study. During the analysis phase, a further 118 participants were excluded because they had missed physical fitness tests (if any of the endurance or muscle fitness test results were missing, the physical fitness index [PFI] could not be calculated). Thus, the final study group consisted of 727 men with mean (SD) age of 25 (5) years. The participants signed a written consent form indicating that they were aware of the risks and benefits of the study. The study was approved by the ethical committees of the University of Jyväskylä and the Central Finland Health Care District, as well as the Headquarters of the Finnish Defence Forces.
In public health and in medicine, the concept of health-related quality of life refers to a person's or group's perceived physical and mental health over time. In this study HRQoL data were collected using the Finnish Rand 36-item health survey 1.0, which was developed from the original 36-Item Short Form Health Survey (SF-36) . RAND-36 measures eight dimensions: general health, physical functioning, role limitation physical, role limitation emotional, vitality, mental health, social functioning, and bodily pain. There is a 0-100 range in each subscale, with higher scores indicating higher HRQoL. The reliability and validity of the scale has reported to be good (Cronbach's alpha coefficients for 8 dimensions varied between 0.80 and 0.94), but ceiling effects were detected for physical functioning, role limitation physical and social functioning dimensions and floor effect for role limitation physical, role limitation emotional dimensions . The age- and sex-weighted Finnish general population was used as a reference study group .
Physical fitness index (PFI)
Oxygen uptake (VO2max) was indirectly measured using a bicycle ergometer test (Ergoline 800 S, Ergoselect 100 K or 200 K, Bitz, Germany) . The handlebars and seats were individually adjusted. After a 5-min warm up, the test began with a power output of 75 W, which was increased by 25 W after every other minute. The pedalling rate of 60 rpm was maintained throughout the test. The heart rate (HR) was recorded continuously (Polar Vantage NV or S610, S710 or S810, Kempele, Finland). The test was terminated at volitional exhaustion, including a decrease in the pedalling rate to below 50 rpm. Predicted VO2max was determined from the HR and power (Fitware, Mikkeli, Finland), as follows: VO2max (ml·kg-1·min-1) = [(Pmax * 12.48) + 217]/body mass, where Pmax is maximal power. The test-retest repeatability was r = 0.89 and 0.96 for women and men, respectively .
Muscle fitness was measured by four consecutive tests: grip strength, push-ups, sit-ups, and repeated squats . Before testing commenced, supervisors demonstrated the technically correct way to perform each test; they also controlled the performance technique of each person. Isometric grip strength was measured in a sitting position (90° elbow angle) by a dynamometer (Saehan Corporation, Masan, South Korea). The test was repeated twice separately for both hands; the best results for the right and left hands were averaged for the outcome . Sit-ups, which measure performance of abdominal and hip-flexor muscles, were done with each subject lying supine on the floor with his hands behind the neck and directing his elbows forward. The knees were flexed at an angle of 90°, the legs were slightly apart, and the assistant supported the ankles. During the movement, the each subject lifted his upper body and touched his elbows to the knees. Push-ups, which measure performance of arm- and shoulder-extensor muscles, were started from the lowest face-down position. Each subject's hands were kept shoulder-wide and level. The fingers were directed forward, and the legs were kept parallel and close to each other. During the movement, the arms were fully extended and the torso was straightly tensed. In the second phase, the torso was lowered down to an elbow angle of 90°. Repetitive squats measure the strength of the knee extensors. The subject was standing with feet just inside shoulder width apart and squat was performed until the thighs were horizontal. The results of the push-ups, sit-ups, and repeated squats were expressed as the number of correctly performed repetitions within 60 s. The recovery time between each of the tests was 5-10 min.
In PFI calculations the absolute results for each muscle fitness test were scored to corresponding fitness categories from poor (1.0-1.9) to excellent (5.0-5.9). The total muscle fitness index was the sum of 4 muscle fitness tests. Finally PFI was determined utilizing an adjusted nomogram" where aerobic fitness and muscle fitness are equally important (50 and 50%). Accordingly, the PFI also had five different categories: excellent (5.0-5.9), good (4.0-4.9), satisfactory (3.0-3.9), fair (2.0-2.9), and poor (1.0-1.9). For statistical analyses, the PFI was categorized as poor (combination of categories fair and poor), satisfactory, or good (good and excellent) . The reference values are based on the results of 3635 civilians and include 5 year age-specific categories . These VO2max and muscle fitness tests have been used during this past decade (2000-2009) in the Finnish Defense Forces in order to follow-up the fitness components of professional soldiers and reservists and, in addition, to find out the general population based trends in fitness changes.
The frequency and intensity of weekly LTPA was determined from responses to a single question with six categories: (1) no physical activity at all, (2) some physical activity without feeling out of breath or sweating, (3) physical activity with feeling out of breath or sweating once a week, (4) physical activity with feeling out of breath or sweating twice a week, (5) physical activity with feeling out of breath or sweating three times a week, and (6) physical activity with feeling out of breath or sweating at least four times a week. In the analysis, the participants were recorded to three groups according their physical activity level: low (combination of LTPA categories 1 and 2), moderate (categories 3 and 4), or high (categories 5 and 6) .
Height and weight were measured while the participants were wearing lightweight clothing. Body mass index (BMI) was classified in five categories: severe obesity, ≥35.0; obesity, 30.0-34.9; overweight, 25.0-29.9; normal 19.0-24.9; and underweight, ≤18.9. Body fat and lean mass percentages were recorded using the eight-polar bioimpedance method with multifrequency current (InBody 720; Biospace Company, Seoul, Korea). Bioimpedance was performed in the postabsorbtive state after a 12-hour overnight fast and the day preceding the measurement day was a rest day from intensive exercise. For men the test-retest reliability of the device has shown to be high (ICC 0.9995) and no significant mean (SD) difference was found for body fat between two trials [20.98 (8.88)% and 21.00 (8.83)% .
Alcohol and tobacco product use was determined by a questionnaire. In addition, a number of self-reported morbidities that had been diagnosed by medical doctors were discovered by asking the respondents if they had pulmonary or heart disease, hypertension, inflammatory joint disease, or musculoskeletal disease. Self-perceived general health was assessed using a visual analogue scale, and self-perceived physical fitness compared to age mates was asked using five categories (highly lower, somewhat lower, equal, somewhat better, highly better).
The results are provided as means with standard deviation (SD) or 95% confidence level (CI). The normality of variables was evaluated by Kolmogorov-Smirnoff test and by means of histograms. The statistical significance of characteristics among the groups was evaluated by analysis of variance (ANOVA). If the variables did not fill normality assumptions, Kruskal-Wallis nonparametric test with appropriate pair-wise comparisons or chi-square test was used. The Finnish population values for the eight dimensions were weighted to match the age distribution of the study population. Associations between HRQoL and the explanatory parameters (age, LTPA, BMI, tobacco use, and morbidities) were analyzed using the logistic regression analysis model. Before regression analysis Spearman's Rank correlation coefficient was used to give an indication of the magnitude of association (collinearity) between explanatory variables and they were considered highly associated if their correlation coefficient was greater than 0.7.
Sample characteristics by physical fitness index.
Physical fitness index
P-value between the groups
Poor (n = 328)
Satisfactory (n = 271)
Good (n = 128)
Age in years, mean (SD)
Weight, kg, mean (SD)
Height, cm, mean (SD)
Body mass index, n (%)
< .0.001 *
Body fat, mean (SD)
Lean body mass, mean (SD)
Alcohol users ≥ once a week, n (%)
Tobacco users, n (%)
Snuff users, n (%)
Self perceived general health, mean(SD)
Self-reported morbidities, n (%)
Self perceived physical fitness compared to age mates, n (%)
< 0.001 *
Self-reported leisure time physical activity, n (%)
The proportion of tobacco use increased with decreasing PFI. Self-perceived general health was lower in the poor PFI group. The number of other morbidities did not differ among the groups. The most commonly reported morbidities were musculoskeletal disease (n = 171), pulmonary or heart disease (n = 45), and hypertension (n = 34).
In the poor objectively measured PFI group, 45% of the participants graded their self-perceived physical fitness as lower compared to age mates, while 9% graded it as higher (Table 1). In the good PFI group, the respective proportions were 1% and 67%. A higher frequency of LTPA was associated with a higher PFI. The correlation between PFI and LTPA was 0.49 (95% CI 0.44-0.55).
Health related quality of life (RAND-36) in 727 Finnish young men according to their physical fitness index (PFI)
between the groups*
Mean (95% Cl)
Mean (95% Cl)
Mean (95% Cl)
General health perception
70.0 (67.4 to 72.5)
74.5 (72.4 to 76.7)
74.2 (72.2 to 76.3)
95.2 (94.0 to 96.3)
95.5 (94.6 to 96.4)
97.6 (96.3 to 98.9)
Role limitation physical
93.9 (91.1 to 96.8)
92.4 (89.1 to 95.8)
91.9 (88.9 to 94.7)
Role limitation emotional
87.9 (83.6 to 92.2)
89.5 (85.4 to 93.6)
93.9 (90.8 to 97.0)
68.5 (65.6 to 71.5)
74.5 (72.2 to 76.7)
71.3 (69.3 to 73.3)
78.8 (76.5 to 81.1)
81.179.0 to 83.1)
78.6 (76.8 to 80.4)
90.9 (88.4 to 93.5)
88.8 (86.4 to 91.1)
92.8 (90.9 to 94.7)
80.6 (77.7 to 83.4)
81.6 (79.3 to 83.9)
79.3 (76.8 to 81.8)
Logistic regression analysis of eight HRQoL dimensions (RAND-36).
General health perception
Role limitation physical
Role limitation emotional
0.98 (0.94 to 1.01)
0.96(0.92 to 0.99)*
1.00(0.95 to 1.04)
1.05(1.00 to 1.10)*
1.08(1.03 to 1.12)*
1.05(1.01 to 1.09)*
1.02(0.98 to 1.06)
0.98(0.94 to 1.01)
1.63 (1.27 to 2.09)*
1.56(1.19 to 2.05)*
1.05(0.77 to 1.43)
1.09(0.84 to 1.42)
1.15(0.91 to 1.45)
1.01(0.80 to 1.28)
1.09(0.87 to 1.37)
1.09(0.86 to 1.39)
1.27 (1.12 to 1.43)*
1.28(1.12 to 1.46)*
0.99(0.85 to 1.16)
1.03(0.90 to 1.17)
1.12(1.00 to 1.26)*
1.01(0.90 to 1.14)
1.05(0.93 to 1.17)
1.08(0.96 to 1.22)
1.01 (0.96 to 1.06)
0.98(0.93 to 1.03)
1.01(0.95 to 1.08)
1.01(0.96 to 1.07)
1.04(0.99 to 1.09)
1.02(0.97 to 1.07)
1.05(1.00 to 1.10)
1.00(0.96 to 1.06)
0.47 (0.33 to 0.65)*
0.30(0.21 to 0.43)*
0.39(0.26 to 0.59)*
0.60(0.42 to 0.85)*
0.61(0.44 to 0.84)*
0.62(0.45 to 0.86)*
0.56(0.41 to 0.77)*
0.24(0.17 to 0.34)*
Results of the present study showed in a relatively large sample of Finnish men that higher PFI was associated with more favorable scores in the general health, physical functioning, mental health, and vitality dimensions of HRQoL. The importance of PFI was supported by our finding that the good and satisfactory PFI groups had a higher HRQoL score in all of the dimensions except for bodily pain, compared to the reference values of the age- and gender-weighted Finnish population. The lack of difference in the bodily pain dimension may reflect the fact that the number of morbidities did not differ among the fitness categories. Previous studies have shown that cardiorespiratory fitness is associated with physical functioning in 40-65-year-old participants with diabetes  and 40-60-year-old Finnish men working in blue-collar occupations . When we repeated regression analysis of our study group and entered VO2max and muscle fitness index separately in the model, instead of combined PFI, VO2max was associated with general health perception and muscle fitness index was associated with physical functioning and general health perception (data not shown). A recent study including healthy 18-49 years old men from United States navy showed a positive relationship between submaximal exercise test and mental and physical health components of HRQoL .
The results presented here provide support for earlier findings of cross-sectional studies, which showed that higher levels of LTPA were associated with certain HRQoL dimensions [20–22]. Vuillemin et al. (2005) reported that in men, LTPA was related to all of the other dimensions except for emotional role functioning . Wendel-Vos et al. (2004) showed that meeting recommended levels of physical activity (at least 30 minutes of moderate LTPA per day) was associated with higher HRQoL scores in all dimension . When interpreting our results and the results of others, it is important to note that some participants may under- or overestimate the intensity of their LTPA. In the present study, over half of the participants in the poor PFI category reported that their LTPA was moderate or high, while some of the participants in the good PFI category reported that it was low. Some respondents may not perceive their activity as sufficiently moderate or vigorous, and may have underestimated their LTPA level. Likewise, some respondents may have misreported their PA levels to reflect the socially desirable nature of PA participation; thus, they may have overestimated their LTPA level . However, we found that both self-reported LTPA levels and measured PFIs were associated with the general health perception and physical functioning dimension. Our finding that LTPA was also associated with vitality dimension is supported by a review by Puetz (2006) showing that people who are physically active in their leisure time have about a 40% reduced risk of experiencing feelings of low energy and fatigue compared to sedentary people .
In the good PFI group, we found that the proportion of body fat was lower than in the low PFI group. However, the amount of lean body mass did not differ among the PFI groups, although BMI increased with decreasing PFI. BMI was not associated with HRQoL. Further, when the percentage of body fat was entered into the regression model instead of BMI, the only statistically significant association we found was that a high body fat percentage was associated with the better mental health dimension (data not shown). The findings of previous studies of the effect of body weight on HRQoL are controversial. Some studies have reported that obese adolescents have a poorer HRQoL than lean individuals . On the other hand, in accordance with our results, other studies did not find a significant relationship between BMI and HRQoL . These confounding results of different studies may be partly explained by differences in the gender, sample size, age, and range of BMI of the participants. Furthermore, it is possible for a healthy, well-trained muscular individual with very low body fat to be classified as obese using the BMI formula. However, higher body fatness and lower physical fitness has reported to be associated with metabolic risk factors even in late adolescent college students thus increasing the risk of chronic diseases later in life .
Morbidities were an important explanatory variable of the impairments found in all eight HRQoL dimensions. The diseases that were reported decreased the physical, mental, and social functioning of the participants. A previous study showed that musculoskeletal pain has a negative effect on the HRQoL of elderly people living in Turkey . A German study found that general practice patients with chronic diseases had impaired quality of life, particularly with regard to physical health . The independent effects of the morbidities on HRQoL varied depending upon the type of chronic disease: HRQoL appeared to be more affected by diseases such as depression, back pain, osteoarthritis of the knee, and cancer than by hypertension and diabetes . Asymptomatic status and health risks such as hypertension or MBO were reported to be less likely to affect quality of life [29, 31], while study participants were more conscious of and thus affected by physical medical symptoms leading to a discernable limitation in performance [32, 33].
In Finland a universal male conscription is in place, under which all men above 18 years of age serve for 6, 9 or 12 months, these reservists which are invited to the refresher courses represent rather well Finnish young men. Some of the reservists from which we drew our study participants were unable to attend the courses because of personal or social reasons or health conditions, or because they were living abroad. Thus, a limitation of the present study is that we do not know the characteristics of those reservists who did not enter the courses. It was previously suggested that males may underestimate problems of functional capacity and pain on questionnaires [32, 34], which may also have affected the data regarding our study participants. The range of the age was 20-47 years. Increasing age does not necessarily cause a reduction in the quality of life, but it may shift the emphasis of it as shown with the present data. Although 32% of the participants had self-reported morbidities, the ceiling effect was over 15% in 5 out of 8 dimensions of HRQoL (physical functioning, role limitation physical, role limitation emotional, social functioning and bodily pain). However, although this is a cross-sectional study, the strength of this study is that participants' subjective perspectives on physical fitness and health were accompanied by objective measurements of maximal aerobic capacity and muscle endurance, making the findings more accurate and dependable.
The present study on Finnish young adult men showed that higher physical fitness and leisure-time physical activity level promotes certain dimensions of HRQoL, and the higher number of morbidities impairs all of them. Because physical fitness was associated with the young men's HRQoL and health and, thus, their value to the present and future labour force, feasible methods to promote PA levels and thereby HRQoL in young men should be pursued.
This work was supported by The Scientific Committee for National Defense
- Bize R, Johnson JA, Plotnikoff RC: Physical activity level and health-related quality of life in the general adult population: a systematic review. Prev Med 2007, 45: 401–15. 10.1016/j.ypmed.2007.07.017PubMedView ArticleGoogle Scholar
- US Department of Health and Human Services. Physical activity guidelines for Americans 2008. [http://www.health.gov/PAguidelines]
- Eurobarometer on Health and Food 2005. [http://www.heartstats.org/datapage.asp?id=4695]
- Fogelholm M, Männistö S, Vartiainen E, Pietinen P: Determinants of energy balance and overweight in Finland 1982 and 1992. Int J Obes Relat Metab Disord 1996, 20: 1097–1104.PubMedGoogle Scholar
- Penedo FJ, Dahn JR: Exercise and well-being: A review of mental and physical health benefits associated with physical activity. Curr Opin Psychiatry 2005, 18: 189–193. 10.1097/00001504-200503000-00013PubMedView ArticleGoogle Scholar
- Sorensen LE, Pekkonen MM, Mannikko KH, Louhevaara VA, Smolander J, Alen MJ: Associations between work ability, health-related quality of life, physical activity and fitness among middle-aged men. Appl Ergon 2008, 39: 786–791. 10.1016/j.apergo.2007.11.001PubMedView ArticleGoogle Scholar
- Weyer SKB: Physical exercise and psychological health. Sport Med 1994, 17: 108–116. 10.2165/00007256-199417020-00003View ArticleGoogle Scholar
- McAuley E, Bane SM, Rudolph DL, Lox CL: Physique anxiety and exercise in middle-aged adults. J Gerontol B Psychol Sci Soc Sci 1995, 50: P229–35.PubMedView ArticleGoogle Scholar
- Rejeski WJ, Mihalko SL: Physical activity and quality of life in older adults. J Gerontol A Biol Sci Med Sci 2001,56(Spec No 2):23–35.PubMedView ArticleGoogle Scholar
- Lavie CJ, Milani RV: Disparate effects of improving aerobic exercise capacity and quality of life after cardiac rehabilitation in young and elderly coronary patients. J Cardiopulm Rehabil 2000, 40: 235–40. 10.1097/00008483-200007000-00004View ArticleGoogle Scholar
- Rejeski WJ, Lang W, Neiberg RH, Van Dorsten B, Foster GD, Maciejewski ML, Rubin R, Williamson DF, Look AHEAD Research Group: Correlates of health-related quality of life in overweight and obese adults with type 2 diabetes. Obesity 2006, 14: 870–83. 10.1038/oby.2006.101PubMedView ArticleGoogle Scholar
- Shibata A, Oka K, Nakamura Y, Muraoka I: Recommended level of physical activity and health-related quality of life among japanese adults. Health Qual Life Outcomes 2007, 5: 64. 10.1186/1477-7525-5-64PubMed CentralPubMedView ArticleGoogle Scholar
- Sloan RA, Sawada SS, Martin CK, Church T, Blair SN: Associations between Cardiorespiratory Fitness and Health-Related Quality of Life Health. Qual Life Outcomes 2009, 7: 47. 10.1186/1477-7525-7-47View ArticleGoogle Scholar
- Aalto A-M, Aro S, Aro A, Mähönen M: Rand 36-item health survey 1,0. Suomenkielinen versio terveyteen liittyvästä elämänlaadun kyselystä. In Kyselylomake ja käyttöohjeet. Abstract in English. Helsinki, Finland: Stakes; 1995.Google Scholar
- Fogelholm M, Malmberg J, Suni J, Santtila M, Kyröläinen H, Mäntysaari M: Waist circumference and BMI are independently associated with the variation of cardio-respiratory and neuromuscular fitness in young adult men. Int J Obes (Lond) 2006, 30: 962–969. 10.1038/sj.ijo.0803243View ArticleGoogle Scholar
- Fogelholm M, Malmberg J, Suni J, Santtila M, Kyröläinen H, Mäntysaari M, Oja P: International Physical Activity Questionnaire: Validity against fitness. Med Sci Sports Exerc 2006, 38: 753–60. 10.1249/01.mss.0000194075.16960.20PubMedView ArticleGoogle Scholar
- Kyröläinen H, Häkkinen K, Kautiainen H, Santtila M, Pihlainen K, Häkkinen A: Physical fitness, BMI and sickness absence in male military personnel. Occup Med (Lond) 2008, 58: 251–256. 10.1093/occmed/kqn010View ArticleGoogle Scholar
- Kyröläinen H, Häkkinen A, Kautiainen H, Santtila M, Pihlainen K, Häkkinen K: Puolustusvoimien palkatun henkilöstön fyysistä suorituskykyä mittaavan testimenetelmän viitearvoluokittelun ja kuntoindeksin validointitutkimus. Fyysisen kunnon, painoindeksin ja sairauspoissaolojen väliset yhteydet. Pääesikunta, Koulutusosasto 2006. ISBN 951–25–1677–2Google Scholar
- Bennett WL, Ouyang P, Wu AW, Barone BB, Stewart KJ: Fatness and fitness: How do they influence health-related quality of life in type 2 diabetes mellitus? Health Qual Life Outcomes 2008, 6: 110. 10.1186/1477-7525-6-110PubMed CentralPubMedView ArticleGoogle Scholar
- Vuillemin A, Boini S, Bertrais S, Tessier S, Oppert JM, Hercberg S, Guillemin F, Briancon S: Leisure time physical activity and health-related quality of life. Prev Med 2005, 41: 562–569. 10.1016/j.ypmed.2005.01.006PubMedView ArticleGoogle Scholar
- Brown DW, Balluz LS, Ford ES, Giles WH, Strine TW, Moriarty DG, Croft JB, Mokdad AH: Associations between short- and long-term unemployment and frequent mental distress among a national sample of men and women. J Occup Environ Med 2003, 45: 1159–1166. 10.1097/01.jom.0000094994.09655.0fPubMedView ArticleGoogle Scholar
- Wendel-Vos GC, Schuit AJ, Tijhuis MA, Kromhout D: Leisure time physical activity and health-related quality of life: Cross-sectional and longitudinal associations. Qual Life Res 2004, 13: 667–677. 10.1023/B:QURE.0000021313.51397.33PubMedView ArticleGoogle Scholar
- Brown DW, Balluz LS, Giles WH, Beckles GL, Moriarty DG, Ford ES, Mokdad AH, behavioral risk factor surveillance system (BRFSS): Diabetes mellitus and health-related quality of life among older adults. findings from the behavioral risk factor surveillance system (BRFSS). Diabetes Res Clin Pract 2004, 65: 105–115. 10.1016/j.diabres.2003.11.014PubMedView ArticleGoogle Scholar
- Puetz TW: Physical Activity and Feelings of Energy and Fatigue: Epidemiological Evidence. Sports Med 2006, 36: 767–80. 10.2165/00007256-200636090-00004PubMedView ArticleGoogle Scholar
- de Beer M, Hofsteenge GH, Koot HM, Hirasing RA, Delemarre-van de Waal HA, Gemke RJ: Health-related-quality-of-life in obese adolescents is decreased and inversely related to BMI. Acta Paediatr 2007, 96: 710–714. 10.1111/j.1651-2227.2007.00243.xPubMedView ArticleGoogle Scholar
- Kruger J, Bowles HR, Jones DA, Ainsworth BE, Kohl HW, Health-related quality of life, BMI and physical activity among US adults (>/= 18 years): National physical activity and weight loss survey, 2002. Int J Obes (Lond) 2007, 31: 321–327. 10.1038/sj.ijo.0803386View ArticleGoogle Scholar
- Sacheck JM, Kuder JF, Economos CD: Physical Fitness, Adiposity and Metabolic Risk Factors in Young College Students. Med Sci Sports Exerc 2009, in press.Google Scholar
- Cavlak U, Yagci N, Bas Aslan U, Ekici G: A new tool measuring health-related quality of life (HRQOL): The effects of musculoskeletal pain in a group of older Turkish people. Arch Gerontol Geriatr 2008, in press.Google Scholar
- Wang HM, Beyer M, Gensichen J, Gerlach FM: Health-related quality of life among general practice patients with differing chronic diseases in Germany: Cross sectional survey. BMC Public Health 2008, 8: 246. 10.1186/1471-2458-8-246PubMed CentralPubMedView ArticleGoogle Scholar
- Rijken M, van Kerkhof M, Dekker J, Schellevis FG: Comorbidity of chronic diseases: effects of disease pairs on physical and mental functioning. Qual Life Res 2005, 14: 45–55. 10.1007/s11136-004-0616-2PubMedView ArticleGoogle Scholar
- Schwartz CE, Sprangers MA: Methodological approaches for assessing response shift in longitudinal health-related quality-of-life research. Soc Sci Med 1999, 48: 1531–1548. 10.1016/S0277-9536(99)00047-7PubMedView ArticleGoogle Scholar
- Häkkinen A, Kukka A, Onatsu T, Järvenpää S, Heinonen A, Kyröläinen H, Tomas-Carus P, Kallinen M: Health-related quality of life and physical activity in persons at high risk for type 2 diabetes. Disabil Rehabil 2008, in press.Google Scholar
- Cummins R, Lau A, Stokes M: HRQOL and subjective well-being: Noncomplementary forms of outcome measurement. Expert Rev Pharmacoecon Outcomes Res 2004, 4: 413–420. 10.1586/14737184.108.40.2063PubMedView ArticleGoogle Scholar
- Wingard DL: The sex differential in morbidity, mortality, and lifestyle. Annu Rev Public Health 1984, 5: 433–458. 10.1146/annurev.pu.05.050184.002245PubMedView ArticleGoogle Scholar
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