Quality of life and life circumstances in German myasthenia gravis patients
© Twork et al. 2010
Received: 1 July 2010
Accepted: 11 November 2010
Published: 11 November 2010
Myasthenia gravis (MG) is a chronic neuromuscular disease. Advances in medical therapy have continuously increased the life expectancy of MG patients, without definitively curing the disease. To analyze life circumstances and quality of life (QoL), a large German MG cohort was investigated.
Methods and Sample
In cooperation with the German Myasthenia Association, 2,150 patients with confirmed MG were asked to respond to a mailed questionnaire. The standardized questions related to demographic data, impairments, therapeutic course, use of complementary therapies, illness-related costs, and quality of life (SF-36). In total, 1,518 patients participated, yielding a response rate of 70.6%. The average age was 56.7 years, and the proportion of females 58.6%.
Despite receiving recommended therapy, many patients still suffered from MG-related impairments. In particular, mobility and mental well-being were reduced; moreover, quality of life was markedly reduced. Stepwise linear regression analysis revealed illness stability, impairments, mental conditions, comorbid diseases, and employment to be determinants of QoL.
Results indicate that despite prolonged life expectancy among MG patients, health-related quality of life is low. This outcome resulted mainly from impaired mobility and depression. Physical and mental well-being might be improved by additional therapy options. Additionally, health care resources could be used more efficiently in these patients.
List of abbreviations
complementary and alternative medicine
Myasthenia Gravis Foundation of America
quality of life
Myasthenia gravis (MG) is a chronic, autoimmune, neuromuscular disease. The annual incidence is reported as being 0.25-4 patients per 100,000 residents, with a prevalence of 8-15 patients per 100,000 residents. The first peak of onset is around the second and third decades of life, with another one around the fifth and sixth decades. Onset of MG up to the 40th year of life especially concerns women [1–6]. Myasthenic symptoms affect striated muscles. The hallmark of MG is painless, fluctuating or fatiguing weakness . Patients complain early about diplopia. They often present with uni- or bilateral ptosis. Additional manifestations are bulbar symptoms such as speech and chewing disorders and dysphagia. Weakness of mimetic musculature (facies myopathica), proximal limbs, and trunk musculature can occur. In a few cases, severe muscle weakness results in respiratory failure. Typically, symptoms increase during the daytime and improve with rest [3–5]. In addition, it has been suggested that cognitive functions such as response fluency, information processing, and verbal as well as visual learning may be involved [8, 9].
Nowadays, MG is graded by the MGFA Clinical Classification of Myasthenia Gravis 2002, a derivative of Osserman's and Genkins' classification system [10, 11]. The pathogenetic background of the disease involves mainly antibodies (besides other types, especially acetylcholine receptor antibodies (AchR)), which impair neuromuscular transmission [1, 4, 6, 12]. In most patients a hyperplasia of the thymus (70%-85%) and, in some cases, a thymoma (10%-15%) can be found [7, 13]. According to the pathogenesis, several therapeutic strategies are applied, which range from acetylcholine esterase inhibitors such as pyridostigmine, immunosuppressors and - modulators (e.g. azathioprine, corticosteroids, methotrexate or FK506 (Tacrolimus®), to plasmapheresis, immunoadsorption, intravenous immunoglobulins or remove of the thymus [2–4, 14–24].
Advances in medical therapy have continuously increased the life expectancy of MG patients without definitively curing the disease . Within the last 10 years quality of life (QoL) aspects concerning MG were focused increasingly. MG patients often are not able to participate fully in daily life, mainly due to their muscle weakness. The persistent experience of weakness may negatively influence patients' perceived quality of life, especially among individuals for whom demands of work, family, and other responsibilities require significant physical involvement [25, 26].
In 2000 a Task Force of the Myasthenia Gravis Foundation of America recommended the development of a QoL measure specific for MG. Extant investigations have relied solely on assessment of physical aspects of daily living in conceptualizing QoL ignoring important psychological factors . Up to now, there are some studies (mainly clinical settings with a limited number of participants) measuring health-related QoL in MG. Tools as the widely recognized, nondisease-specific SF-36 questionnaire or the EQ-5D were applied and new, more MG-focusing questionnaires as the Myasthenia Gravis Quality of Life Scale (MG-QOL) and a shorter version, the MG-QOL15, were developed and evaluated [25–30].
The main findings of these QoL-related studies are that there is a reduction in health-related QoL, compared to normative values or control group, and this reduction is much more marked in physical domains [25, 30–32].
Two retrospective studies evaluated the outcome of minimally invasive thymectomy employing health-related QoL measures (modified QoL-questionnaire of the European Organization for Research and Treatment of Cancer). They both found that patients that underwent thymectomy reported a slightly better health-related QoL compared to those that underwent a conservative approach: such a better outcome was particularly evident in younger patients and those with a lower modified Osserman score [32, 33].
Three papers reported the result of a trial in which mycophenolate mofetil (MMF) was used in patients with MG [27, 28, 34]. The general result was that health-related QoL (SF-36) of MG patients, both on MMF and on placebo, improved in a 36-weeks period . However, such an improvement was not statistically significant.
Two recent papers jointly evaluated disability and health-related QoL in MG [35, 36]. They evaluated the relationships between QoL and the level of disability by relying on the SF-36 and on the World Health Organization Disability Assessment Schedule II (WHO-DAS II), whose validation has been recently published on QoL . The first study reported a significant relationship between MG severity, QoL and disability profile. The second one showed significant correlations between disability and QoL, more with physical than with mental domains.
Aim of this study was to analyze precise life circumstances (e.g. impairments, therapeutic course, use of the health care system, use of complementary and alternative medicine) and resulting QoL and its determinants in a large non-clinical German cohort with confirmed MG.
To get access to a suitable amount of data from German MG patients, a cooperation with the German Myasthenia Association, the self-help organization for MG patients in Germany, was established. All of the 2,150 patient members of this organization with confirmed MG were asked to respond anonymously to a mailed questionnaire [38, 39]. The standardized questions concerned demographic data, physical and social impairments, frequency of handicapped person's pass (in Germany delivered at a certain level of impairment after proof by the "pension office" with a record concerning the degree of handicap (in %)), therapeutic course, comorbid diseases, use of the health care system, use of complementary and alternative medicine (CAM), illness-related costs, and QoL. A cover letter explained the purpose of the study to the participants, and a pre-paid envelope to return the questionnaire was included.
QoL was measured by a visual analogue scale with values from 0 to 100 and by the recognized German version of the SF-36 . QoL data on the German normative sample were derived from the German National Health Survey 1998 . The SF-36 is a self-administered measure of QoL that was developed to examine the impact of disease on perceived well-being. The SF-36 has been used extensively to assess QoL in patients with various diseases and has demonstrated good reliability and validity . The instrument consists of 36 questions that inquire about the general health status of patients. The questions can be summarized in eight scaled categories: physical functioning (interference with physical activities), physical role (degree to which physical health necessitated change in activities during the previous four weeks), bodily pain (amount of pain experienced during the previous four weeks), general health (overall perceived health), emotional role (degree to which emotional health necessitated a change in activities during the previous four weeks), mental health (overall mood during the previous four weeks), vitality (perceived energy during the previous four weeks), and social functioning (interference with social activities) .
For the statistical analysis, SPSS version 16.0 was used. Applied methods were analyses of frequency (mean, median, standard deviation), t-tests for independent samples, and stepwise linear regression analysis. The research protocol of the study was carried out in accordance with the Declaration of Helsinki. All subjects received written information on the study and gave written informed consent prior to participation. An ethical approval was not necessary because there was no intervention on the patients except the survey.
In total, 1,518 patients participated, yielding a response rate of 70.6%.
The average age of the 1,518 patients was 56.7 years (sd: 16.9 years); 38.1% of the patients were aged 65 years or older. The percentage of females was 58.6%.
Most of the patients (66.3%) were married; however, 21.5% were single, separated, or divorced, and 10.6% were widowed. Living alone was reported by 20.6% of MG patients.
Of the total, 63.1% lived in areas with fewer than 100,000 inhabitants, 20.3% in areas with 100,000-500,000 inhabitants, and 13.8% in areas with more than 500,000 inhabitants.
The overall educational level was moderate to high: 38.4% attended the "Volksschule" or "Hauptschule" (total duration of education 8-9 years), 31.6% attended the "Mittelschule" (total duration of education 10 years), and 27.1% attended the "Gymnasium" (total duration of education 12-13 years). Only 1% of the participants attended a school for special needs or did not obtain a school-completion certificate.
Ninety-two percent of the patients needed no services from nursing care insurance; however, 58.2% had a handicapped person's pass (in Germany delivered at a certain level of impairment after proof by the "pension office"), and the cohort's average degree of handicap recorded in their passes was 68%.
Nevertheless, 25.8% of the patients worked more than 15 hours per week and 3.1% fewer than 15 hours. No employment was reported by 69.2% of patients; the main reason for unemployment was age and disability related retirement.
Patients experienced their first MG symptoms at an average age of 43.6 years (sd: 19.6 years). Among women, the first symptoms occurred at an average age of 36.9 years (sd: 18.4 years), and diagnosis was made at an average age of 40.6 years (sd: 18.1 years). Among men, the average age at symptom onset was 53.4 years (sd: 16.8 years), and diagnosis was made at an average age of 55.2 years (sd: 16.1 years). The average duration of disease (from diagnosis up to the survey) was 10.2 years (sd: 9.5 years). The time from first symptoms to diagnosis (time to diagnosis) was on average 2.8 years (sd: 6.3 years). Most of the patients had a stable course of disease (81.9%).
MG-related symptoms and further limitations*.
Proportion in %
Muscle weakness after physical strain
Weakness of upper limbs
Facial expression disorders
Muscle weakness at rest
Concomitant diseases in MG patients*.
Proportion in %
Other immunological diseases
Therapy and Health care services
Nearly all patients (91.2%) had had experiences with acetylcholine esterase inhibitors; 71.4% of them had been treated with azathioprine and 55.4% with corticosteroids. A total of 58.2% of the patients had undergone a thymectomy, 14.0% used intravenous immunoglobulins, and 11.3% underwent plasmapheresis or immunoadsorption. Patients had fewer experiences with cyclosporine A (3.8%), re-thymectomy (1.4%), and radiation (4.2%).
The supervision and treatment of MG was implemented mainly by privately practicing neurologists (61.6%) or by family doctors or general practitioners (50.5%). More than one-third of the participants were treated by hospital doctors (38.8%); only 16.5% were additionally treated by privately practicing internists. Sixty-eight percent of the MG patients consulted a doctor more than six times per year, and 34.1% more than 12 times per year. A healer or non-medical practitioner was consulted by 4.2% of all patients, and 11.1% reported having further treatment by physical therapists.
Most patients (79.6%) had not received physical therapy during the previous three months; however, 9.6% received physical therapy more than six times.
In total, 87.3% of the patients received no psychotherapy. Although 13.0% of the patients were interested in receiving psychotherapy, such therapy was offered to only 11.4% of them.
CAM methods applied by 609 MG patients*.
Kind of CAM
Proportion in %
(n = 609)
Heavy metal detoxification
Healing stones or crystals
The overall monthly household net income was 1750.00 EURO (median, sd: 2207.25 EURO). In 54.9% of the cases, only one person contributed financially to the household's net income. Despite living under a healthcare system that covers all necessary therapies, patients paid 50 EURO (median) monthly to ease MG-related problems; 76.7% spent 25-500 EURO monthly. Such expenses were related to assistance with housekeeping and transportation as well as extra payments for prescribed medications.
In a next step, the influence of MG on patients' lives was elucidated. In 1.9% of the cases, the disease influenced the selection of school and in 8.1% the choice of job. A total of 8.5% of patients changed their job, 21.0% experienced hardships in their job, and 28.3% were forced to retire early due to MG.
Quality of life
Scores for each scale of the SF-36 for all 1,459 MG patients (Score range 0-100).
mean (SD) +
normative population §
mean (SD) +
mean (SD) +
normative population §
mean (SD) +
Stepwise linear regression analysis: Influences on mental and physical health.
Own expenses due to MG
Duration of MG
Stability of MG
Muscle weakness at rest
Muscle weakness after physical strain
Facial expression disorder
Other immunological diseases
Adjusted R2 = 0.609
Adjusted R2 = 0.460
Physical health was negatively associated with walking problems, muscle weakness at rest or after physical strain, miction disorders, and depression. Parameters such as employment and a stable course of MG demonstrated a positive influence on physical health (explanation of variance = 60.9% (adjusted R2 = 0.609)).
Depression, walking problems, and metabolic disorders had a negative influence on mental health, whereas stability of MG showed a positive association with mental health (explanation of variance = 46.0% (adjusted R2 = 0.460)).
Advances in medical therapy and intensive-care technology have increased the life expectancy of MG patients . Within the last 10 years QoL aspects were focused increasingly in studies on MG patients - predominantly in clinical settings with a limited number of patients (see introduction). However, up to now, scant information has emerged from population-based, non-clinical studies regarding MG patients' circumstances of life, experiences with health care and QoL. Therefore, our study focused on impairments, therapeutic course, use of the health care system, use of complementary and alternative medicine, QoL and its determinants among German MG patients.
Before discussing results, several limitations of the study have to be considered.
The cooperation with the German MG self-help organization was established to address as many MG patients as possible. However, it remains unclear whether this specific, organized patient population represents the "common German MG patient".
Data used in this study were extracted from a questionnaire. On the one hand it contained well known standardizes instruments as the SF-36. On the other hand descriptions of many aspects provided by patients are based on unstandardized, pre-determined questions (e.g. presence of MG related problems).
Unfortunately, the SF-36 is a non-disease-specific QoL tool. However, by that means, a comparison to the normative German population was possible. At the time of designing the study no MG-specific QoL tools were available.
As a result of the anonymous design it was not possible to assess patients' exact clinical status of MG according to the MGFA Classification  or to check patients' reports with medical records. Due to the large sample size, clinical assessments of each MG patient in the whole country would have required intensive use of trained neurologists; such a procedure was impossible to implement. To obtain more information on the validity of the results, perhaps future studies should examine a portion of MG patients in order to compare assessments by experts with patients' self-reported answers. Additionally, data could be biased by the selection-bias because probably only very motivated patients took part in the survey. On the other hand, a recall-bias has to be discussed (e.g. concerning length of disease duration).
In the following sections QoL and its determinants are discussed in the context of the international literature.
Results manifested reduced QoL in MG patients compared with a German normative cohort. Compared with normative data, Paul et al. found lower scores in seven of the eight domains of the SF-36 in MG patients (n = 27). The mean ratings concerning mental health were nearly identical to those of our study . Padua et al. investigated 46 MG patients, most of them participated during periods of worsening symptoms [26, 30]. The researchers found that the QoL of their patients was lowered in all scales of the SF-36, however .
Determinants of QoL in MG
In our study, stepwise linear regression analysis revealed that illness stability, impairments, comorbid diseases (e.g. depression), and employment were determinants of QoL. Similar determinants of QoL were found in another German study by Winter et al. : disease severity, depression, older age and increased body-mass-index (n = 37). These specific aspects are discussed more deeply in the following sections.
Disease severity - therapy
International literature also reveals a significant relationship between MG severity groups, QoL and disability profiles [35, 36]. In which way a stable or less severe disease level can be achieved? The most critical time concerning progression of MG encompasses the first 2 to 3 years after onset with an implication for early treatment. After that period, MG tends to stabilize or improve [3, 44]. Spontaneous remissions even have been reported . Mantegazza et al. reported the factors associated with complete, stable remission as being age at onset below 40 years, thymectomy, thymic hyperplasia, and female sex . Bachmann et al. showed that patients with generalized MG who underwent thymectomy had significantly greater rates of remission and improvement compared with conservative treatment. Furthermore, they had a significantly greater survival .
Rates of progression of ocular MG to generalized symptoms were reported as being 49%-69% [44, 46]. However, the risk of generalization can be minimized by up to 75% through treatment of patients with corticosteroids or azathioprine . It has to be considered that long-term immunosuppression and thymectomy have been suspected of causing increased illness in elderly patients . Thus, elderly patients require heightened attention from healthcare professionals.
Due to the problems that (1) conventional therapy for MG though does offer treatment but no complete cure and (2) immunosuppressants are linked to severe side effects, the additional therapeutic use of CAM should be considered. Our study has demonstrated the high acceptance of CAM by MG patients. However, it remains unclear whether the use of any particular CAM method results in a measurable improvement of MG-related problems. Specific literature addressing this problem is not yet available. Therefore, MG patients should be discouraged from spending a substantial amount of money on CAM.
Impairments by MG - reduced muscle strength
Reduced muscle strength seems to be an important independent predictor for both physical and mental health.
MG patients often develop a behavioral pattern of advance planning because they have to preserve their muscle strength . They have been described as sometimes avoiding social contacts due to their muscular impairments . However, declines in recreational activities and social interaction are associated with decreased life satisfaction . Among our patients, mobility was limited mainly by muscle weakness at rest or after physical strain, or by weakness of the upper limbs or walking difficulties. Paul et al. reported similar results in a smaller cohort with generalized MG .
Rostedt et al. raised the question if different types of regional muscle involvement, i.e. bulbar, ocular or generalized, in MG patients influence the mental aspects of quality of life. Bulbar and generalized involvement seems to result in an impairment of mental aspects of quality of life, whereas ocular involvement does not so .
Muscular weakness can be treated by drugs. The dose of acetylcholine esterase inhibitors should be well adjusted to muscular weakness. The often-practiced self-adjustment of acetylcholine esterase inhibitor's dose by patients should be supported and not strictly prohibited by physicians . However, patients clearly have to be informed about potential adverse events, including possible cholinergic crisis . Another approach could be encouraging MG patients to use more physical therapy. Through physical training, improvement of muscle force was reported in patients with mild MG ; that improvement plus optimization of gait could enhance mobility. However, little is known about the effects of physiotherapeutic methods among myasthenic patients. In one case, an exacerbation of MG during therapeutic electric stimulation was even reported .
However, in addition to mobility problems, decreased ability to communicate should be considered also . Facial expression disorders, speech difficulties, and swallowing difficulties impair verbal and non-verbal communication . Logopedic methods could ease patients' faciopharyngeal symptoms and speech difficulties, thus improving these areas. However, systematic research concerning that issue is missing.
Comorbid diseases - mental conditions
Comorbid diseases such as depression represent another factor that influences patients' daily activities in the presented study.
All chronic diseases, including MG, may have psychiatric consequences in terms of coping and QoL. However, there are very few and partly confusing data on the prevalence and aetiology of psychiatric symptoms (e.g. depression or anxiety) in MG patients [52–54]. Depression is associated with lowered QoL in a number of chronic illnesses and might result from poor physical health along with limited activity .
Patients in our study showed a high rate of depression. Whether depression occurred as a result of MG or was present before the onset of MG was not determinable from our data.
We agree with Paul et al., who proposed that emotional health should remain a clinical focus . Doering et al. stated that psychotherapeutic techniques may be helpful for MG patients who have psychiatric symptoms but not necessarily for MG patients in general . Prospective, randomized, controlled pharmaco/psychotherapy studies are needed to better direct the management of patients and, thus, improve quality of life during the course of the illness .
Despite being impaired by MG, about 30% of our patients were employed. However, working conditions do not seem to be ideal for those patients. Work-related capabilities are limited mainly by physical impairments. Occupational goals cannot be achieved, and sometimes long terms of unemployment have to be borne . In our results, employment was associated with a higher QoL. However, it is not obvious whether patients who have a better state of health and thus a less impaired QoL are capable of working in the first place or whether employment itself increases QoL. The latter thesis is conceivable because employment increased QoL in patients with cancer, osteoarthritis, and spinal cord injury . For that reason, adequate therapy and adjustments in the workplace are important to keep MG patients in the working environment with such positive consequences as improved health and increased net income. While at work, individuals are stimulated by physical and mental activities and social contacts. In addition, MG patients, especially young ones which face a long job as well as disease period, should be given counseling regarding future job possibilities.
Financial burden of MG
Last but not least, despite the burden of MG on QoL also the financial burden has to be considered. Total annual costs for MG from the societal perspective in Germany were estimated by Schepelmann et al.: EUR 14,950 (95% CI 10,470-21,730) per patient. The main components of costs were the expenditures of health insurance and the loss of productivity of patients and their caregivers. Disease severity of MG and assistance in activities of the daily life were independent cost-driving factors .
However, there are not only costs that have to be covered by the health care system but also by the patient itself. Despite living under a healthcare system that covers neurological therapies, German MG patients incurred additional expenses due to MG (in our study about 50 EURO per month; in some cases up to 500 EURO). Such expenses involved mainly medications, housekeeping assistance, and transportation. Therefore, specific changes in the healthcare system are needed to ease burden and symptoms of MG and the related financial burden for the patient as well as the health care system.
The study indicates that despite prolonged life expectancy, QoL remains reduced in MG patients. Lowered QoL results mainly from symptoms that impair mobility and psychological well-being. MG may not be a major public health problem in terms of the number of patients affected; however, as a chronic problem, it has a major financial impact on the patients themselves and the care system. MG patients spend a considerable amount of money on medications, CAM, and assistance with housekeeping, transportation, and physiotherapy--even under a healthcare system in which neurological therapy is covered by statutory public health insurance. Therefore, it follows that successful managed care of MG patients depends not only on evidence-based therapies but also on other measures that might enhance QoL. By improving mobility, psychological well-being, integration in social surroundings, the stability of disease, and the possibility of employment according to one's physical abilities, increased QoL among MG patients could be achieved. Standardized guidelines for the therapy of MG patients are recommended, in order to avoid inadequate treatment due to the rareness of the disease. Therefore, collaborative networks between general practitioners and neurologists are required to ensure proper health care for MG patients. Consequently, in the near future implementation of disease-management programs for MG patients in Germany should be considered.
The authors thank all study participants for their endurance in working on the questionnaire. We also thank the German Myasthenia Association for their support.
- Juel V, Massey J: Myasthenia gravis. Orphanet J of Rare Dis 2007, 2:44.View Article
- Masuhr KF, Neumann M: Neurologie. 6th edition. Stuttgart: Thieme; 2007.
- Pascuzzi RM: Myasthenia gravis and Lambert-Eaton syndrome. Ther Apher 2002, 6:57–68.PubMedView Article
- Schneider-Gold C, Hartung HP: Myasthenia gravis: Pathogenese, Diagnostik und Therapie. Fortschr Neurol Psychiatr 2004, 72:45–57.PubMedView Article
- Gold R, Schneider-Gold C: Current and Future Standards in Treatment of Myasthenia Gravis. Neurotherapeutics 2008, 5:535–541.PubMedView ArticlePubMed Central
- Marouf W, Sieb JP: Myasthenia gravis und myasthene Syndrome. Z Rheumatol 2009, 68:465–470.PubMedView Article
- Vincent A, Palace J, Hilton-Jones D: Myasthenia gravis. Lancet 2001, 357:2122–2128.PubMedView Article
- Paul RH, Cohen RA, Gilchrist JM, Aloia MS, Goldstein JM: Cognitive dysfunction in individuals with myasthenia gravis. J Neurol Sci 2000, 179:59–64.PubMedView Article
- Marra C, Marsili F, Quaranta D, Evoli A: Determinants of cognitive impairment in elderly myasthenia gravis patients. Muscle Nerve 2009, 40:952–959.PubMedView Article
- Jaretzki A, Barohn R, Ernstoff R, Kaminski H, Keesey J, Penn A, Sanders D: Myasthenia gravis: Recommendations for clinical research standards. Neurology 2000, 55:16–23.PubMedView Article
- Ossermann KE, Genkins G: Studies in myasthenia gravis: review of a twenty-years experience in over 1200 patients. Mt Sinai J Med 1971, 38:497–537.
- Romi F, Skeie GO, Gilhus NE: Muscle antibodies in subgroups of myasthenia gravis patients. J Neurol 2000, 247:369–375.PubMedView Article
- Aarli JA: Myasthenia Gravis in the Elderly. Ann NY Acad Sci 2008, 1132:238–243.PubMedView Article
- Diener HC, Putzki N: Leitlinien für Diagnostik und Therapie in der Neurologie. 4th edition. Stuttgart: Thieme; 2008.
- Drachman DB, Jones RJ, Brodsky RA: Treatment of refractory myasthenia: "Rebooting" with high-dose cyclophosphamide. Ann Neurol 2003, 53:29–34.PubMedView Article
- Komiyama A, Arai H, Kijima M, Hirayama K: Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis. J Neurol Neurosurg Psychiatry 2000, 68:214–217.PubMedView ArticlePubMed Central
- Meriggioli MN, Ciafaloni E, Al-Hayk KA, Rowin J, Tucker-Lipscomb B, Massey JM, Sanders DB: Mycophenolate mofetil for myasthenia gravis: an analysis of efficacy, safety, and tolerability. Neurology 2003, 61:1438–1440.PubMedView Article
- Rilling G, Tettenborn B: The treatment of myasthenia gravis. Schweiz Rundsch Med Prax 2001, 90:1350–1354.
- Wakata N, Saito T, Tanaka S, Hirano T, Oka K: Tacrolimus hydrate (FK 506): therapeutic effects and selection of responders in the treatment of myasthenia gravis. Clin Neurol Neurosurg 2003, 106:5–8.PubMedView Article
- Gronseth GS, Barohn RJ: Practice parameter: Thymectomy for autoimmune myasthenia gravis (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2000, 55:7–15.PubMedView Article
- Werneck LC, Cunha FMB, Scola RH: Myasthenia gravis: a retrospective study comparing thymectomy to conservative treatment. Acta Neurol Scand 2000, 101:41–46.PubMedView Article
- Haupt WF, Rosenow F, van der Ven C, Birkmann C: Immunoadsorption in Guillain-Barré syndrome and myasthenia gravis. Ther Apher 2000, 4:195–197.PubMedView Article
- Yeh JH, Chiu HC: Comparison between double-filtration plasmapheresis and immunoadsorption plasmapheresis in the treatment of patients with myasthenia gravis. J Neurol 2000, 247:510–513.PubMedView Article
- Dalakas MC: Intravenous Immunoglobulin in Autoimmune Neuromuscular Diseases. JAMA 2004, 291:2367–2375.PubMedView Article
- Paul RH, Nash JM, Cohen RA, Gilchrist JM, Goldstein JM: Quality of life and well-being of patients with myasthenia gravis. Muscle Nerve 2001, 24:512–516.PubMedView Article
- Padua L, Evoli A, Aprile I, Caliandro P, Mazza S, Padua R, Tonali P: Health-related quality of life in patients with myasthenia gravis and the relationship between patient-oriented assessment and conventional measurements. Neurol Sci 2001, 22:363–369.PubMedView Article
- Mullins LL, Carpentier MY, Paul RH, Sanders DB: Disease-specific measure of quality of life for myasthenia gravis. Muscle Nerve 2008, 38:947–956.PubMedView Article
- Burns TM, Conaway MR, Cutter GR, Sanders DB: Less is more, or almost as much: A 15-item quality-of-life instrument for myasthenia gravis. Muscle Nerve 2008, 38:957–963.PubMedView Article
- Winter Y, Schepelmann K, Spottke AE, Claus D, Grothe C, Schröder R, Heuss D, Vielhaber S, Tackenberg B, Mylius V, Reese JP, Kiefer R, Schrank B, Oertel WH, Dodel R: Health-related quality of life in ALS, myasthenia gravis and facioscapulohumeral muscular dystrophy. J Neurol 2010, 257:1473–1481.PubMedView Article
- Padua L, Evoli A, Aprile I, Caliandro P, D'Amico P, Rabini A, Tonali P: Quality of life in patients with myasthenia gravis. Muscle Nerve 2002, 25:466–467.PubMedView Article
- Scott KR, Kothari MJ: Self-reported pain affects quality of life in myasthenia gravis. J Clin Neuromuscul Dis 2006, 7:110–114.PubMedView Article
- Bachmann K, Burkhardt D, Schreiter I, Kaifi J, Busch C, Thayssen G, Izbicki JR, Strate T: Long-term outcome and quality of life after open and thoracoscopic thymectomy for myasthenia gravis: Analysis of 131 patients. Surg Endosc 2008, 22:2470–2477.PubMedView Article
- Bachmann K, Burkhardt D, Schreiter I, Kaifi J, Schurr P, Busch C, Thayssen G, Izbicki JR, Strate T: Thymectomy is more effective than conservative treatment for myasthenia gravis regarding outcome and clinical improvement. Surgery 2009, 145:392–398.PubMedView Article
- Sanders DB, Hart IK, Mantegazza R, Shukla SS, Siddiqi ZA, De Baets MH, Melms A, Nicolle MW, Solomons N, Richman DP: An international, phase III, randomized trial of mycophenolate mofetil in myasthenia gravis. Neurology 2008, 71:400–406.PubMedView Article
- Raggi A, Leonardi M, Antozzi C, Confalonieri P, Maggi L, Cornelio F, Mantegazza R: Concordance between severity of disease, disability and health-related quality of life in Myasthenia gravis. Neurol Sci 2010, 31:41–45.PubMedView Article
- Leonardi M, Raggi A, Antozzi C, Confalonieri P, Maggi L, Cornelio F, Mantegazza R: The relationship between health, disability and quality of life in Myasthenia Gravis: Results from an Italian study. J Neurol 2010, 257:98–102.PubMedView Article
- Garin O, Ayuso-Mateos JL, Almansa J, Nieto M, Chatterji S, Vilagut G, Alonso J, Cieza A, Svetskova O, Burger H, Racca V, Francescutti C, Vieta E, Kostanjsek N, Raggi A, Leonardi M, Ferrer M: Validation of the World Health Organization Disability Assessment Schedule (WHODAS-2) in patients with chronic diseases. Health Qual Life Outcomes 2010, 8:51.PubMedView ArticlePubMed Central
- Twork S, Klewer J, Pöhlau D, Kugler J: Experiences with Healthcare Services and Quality of Life among German People with Myasthenia Gravis. In Focus on disability: Trends in Research and Application. Volume 2. Edited by: Kroll T. New York: Nova Science Publishers, Inc; 2008:181–205.
- Wondzinski L: Versorgungssituation von Patienten und Patientinnen mit Myasthenia gravis unter besonderer Berücksichtigung der medizinischen Versorgung und der Lebensqualität in Bezug auf das Geschlecht und das Alter. PhD thesis Technische Universität Dresden, Department Health Sciences/Public Health 2009.
- Bullinger M, Kirchberger I: Fragebogen zum Gesundheitszustand (SF-36). Göttingen: Hogrefe Verlag; 1998.
- Ellert U, Bellach BM: The SF-36 in the Federal Health Survey-description of a current normal sample. Gesundheitswesen 1999,61(Spec No 2):184–190.
- Kaptchuk TJ, Eisenberg DM: Varieties of Healing. 2: A Taxonomy of Unconventional Healing Practices. Ann Intern Med 2001, 135:196–204.PubMedView Article
- Padua L, Evoli A, Aprile I, Caliandro P, D'Amico P, Rabini A, Tonali P: Quality of life in patients with myasthenia gravis. Muscle Nerve 2002, 25:466–467.PubMedView Article
- Weizer JS, Lee AG, Coats DK: Myasthenia gravis with ocular involvement in older patients. Can J Ophthalmol 2001, 36:26–33.PubMedView Article
- Mantegazza R, Baggi F, Antozzi C, Confalonieri P, Morandi L, Bernasconi P, Andreetta F, Simoncini O, Campanella A, Beghi E, Cornelio F: Myasthenia Gravis (MG): Epidemiological Data and Prognostic Factors. Ann N Y Acad Sci 2003, 998:413–423.PubMedView Article
- Farrugia ME: A limited epidemiological study of seropositive myasthenia gravis in Tayside. Scott Med J 2002, 6:132–135.
- Rohr W, Peter H: Behavior Analysis in Myasthenia Gravis. Psychother Psychosom Med Psychol 1991, 41:35–41.PubMed
- Gulick EE: Correlates of Quality of Life Among Persons With Multiple Sclerosis. Nurs Res 1997, 46:305–311.PubMedView Article
- Rostedt A, Padua L, Stålberg EV: Correlation between regional myasthenic weakness and mental aspects of quality of life. Eur J Neurol 2006, 13:191–193.PubMedView Article
- Lohi EL, Lindberg C, Andersen O: Physical training effects in myasthenia gravis. Arch Phys Med Rehabil 1993, 74:1178–1180.PubMed
- Pease WS, Lagattuta FP: Exacerbation of a case of myasthenia gravis during therapeutic electric stimulation. Arch Phys Med Rehabil 1987, 68:568–570.PubMed
- Kulaksizoglu IB: Mood and anxiety disorders in patients with myasthenia gravis: aetiology, diagnosis and treatment. CNS Drugs 2007, 21:473–481.PubMedView Article
- Doering S, Henze T, Schüßler G: Coping with myasthenia gravis. Nervenarzt 1993, 64:640–647.PubMed
- Rohr W: Myasthenia gravis in the diagnostic frontier area of psychiatry. Psychiat Prax 1992, 19:157–163.
- Doering S, Henze T, Schussler G: Coping With Myasthenia Gravis and Implications for Psychotherapy. Arch Neurol 1993, 50:617–620.PubMedView Article
- Schepelmann K, Winter Y, Spottke AE, Claus D, Grothe C, Schröder R, Heuss D, Vielhaber S, Mylius V, Kiefer R, Schrank B, Oertel WH, Dodel R: Socioeconomic burden of amyotrophic lateral sclerosis, myasthenia gravis and facioscapulohumeral muscular dystrophy. J Neurol 2010, 257:15–23.PubMedView Article
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