Development of a parent version of the Manchester-Minneapolis quality of life survey for use by parents and carers of UK children: MMQL-UK (PF)
© Hutchings et al; licensee BioMed Central Ltd. 2008
Received: 12 June 2007
Accepted: 28 February 2008
Published: 28 February 2008
Although it is now widely endorsed that children should as far as possible rate their own health related quality of life (HRQL), there are situations where proxy information on child HRQL may be useful, especially where a child is too ill or young to provide their own HRQL assessment. There is limited availability of generic HRQL scales that have a parallel child and parent version and that are reliable, valid, brief, comprehensible and suitable for use in UK populations. The aims of this study were therefore to develop and validate a parent version of the anglicised Manchester-Minneapolis Quality of Life child form (MMQL-UK (CF)) and to determine the level of association between the child and parent versions of this form.
This study was undertaken concurrently with the anglicisation and validation of the MMQL, a measure of HRQL developed for use with children in North America. At that time, no parent version existed, so the MMQL form for children (MMQL-UK (CF)) was used as the basis for the development of the MMQL-UK parent form (PF). The sample included a control group of healthy children and their parents and five exemplar groups; children diagnosed with asthma, diabetes or inflammatory bowel disease and their parents, children in remission from cancer and their parents and children in public care and their carers. Consistency of the MMQL-UK (PF) components were assessed by calculating Cronbach's alpha. Validation of the parent questionnaire was undertaken by comparing MMQL-UK (PF) component scores with comparable components on the proxy PedsQL™ quality of life scales, comparing MMQL-UK (PF) component scores between parents of healthy and chronic disease children and by comparison of component scores from children and their parents or carers. Reproducibility and responsiveness were assessed by retesting parents by follow-up questionnaires.
A total of 874 children (completing MMQL-UK (CF)) and 572 parents or carers (completing MMQL-UK (PF)) took part in the study. The internal consistency of all the MMQL-UK (PF) components exceeding the accepted criterion of 0.70 and the construct validity was good with moderate correlations being evident between comparable components of the MMQL-UK (PF) and the proxy PedsQL™. Discriminant validity was demonstrated with significant differences being identified between parents of healthy children and those with chronic conditions. Intra-class correlations exceeded 0.65 for all MMQL-UK (PF) components demonstrating good reproducibility. Weak to moderate levels of responsiveness were demonstrated for all but social functioning. The MMQL-UK (PF) showed moderate parent-child correlation with the MMQL-UK (CF) for all components. The best correlations were seen for those components measuring the same construct (Pearson's r ranged from 0.31 to 0.61, p < 0.01 for equivalent components).
The MMQL-UK (PF) showed moderate to good correlations with the MMQL-UK (CF) component scores. The MMQL-UK (PF) will be of use when comparing child and parent/carer perception of the impact of a child's condition on their HRQL or where the child is too ill or young to provide their own report.
The measurement of health-related quality of life (HRQL) is increasingly becoming part of the overall assessment of a patient's health both in the clinical and the research setting, as it provides a more complete picture of the health of the patient. Measuring HRQL includes assessing the patient's perceptions of their physical, emotional and social health and function that can supplement clinical information on their health status.
It is now widely endorsed that children as far as possible should rate their own HRQL [1, 2]. However, there is some suggestion that children may not be able to provide accurate and reliable assessments of their HRQL  and that this may be due to problems understanding the questions, lack of understanding of the disease itself or time perception differences . Assessment of HRQL in children may also be compromised by their age and development and by their ability to complete lengthy questionnaires .
There are conflicting views regarding the benefits of using proxies for measuring HRQL. There is some doubt as to whether proxy reports provide an accurate reflection of the child's HRQL [3, 6–8]. Patient and proxy reports may differ because of the lack of parallel content in the instruments used . Some studies have highlighted limited concordance between child and parent reports [9–12] whilst others have reported more complementary information from children and their parents [7, 13]. What is important about proxy ratings is understanding when parents are able to provide useful information. This is more likely to be in relation to impact of HRQL on the family, sibling relationships and to a lesser extent school progress . Parents' knowledge of their child is likely to be more limited in relation to activities or relationships that exist outside home and with respect to internal feeling states [9, 10, 12]. Parents also have a role to play when a child is too young or ill to provide a HRQL assessment. It has been suggested that consistent parent-proxy reports may prove to be more reliable and valid in longitudinal HRQL and long-term outcome investigations than their children's own reports alone because of the rapid changes in children's attitudes, abilities, and priorities as part of the normal developmental process . The solution is to regard both child and parental assessment as valid and contributing to the total picture regarding the child's HRQL .
When measuring the HRQL of children it may be necessary or desirable to obtain reports from their parents . Clinicians often look to parents for guidance regarding their child's HRQL as they play an important role in medical decision making . It is important that the clinician is confident in a parent's evaluation of their child's HRQL. If a child is unable to provide HRQL judgements, drawing on alternate sources of information regarding a patient's HRQL may be a useful source of information provided that additional information is available to support the validity of the proxy ratings . Even when a child's responses are available, the perspective of the parent has an important bearing on health care decisions with respect to the child. For these reasons, parallel reporting is increasingly recommended in studies involving the assessment of health outcomes in child populations with analogous questionnaires for children and their parents being developed .
In spite of this, may measures of child HRQL do not include parallel parent versions [17, 18]. For this reason, we report the development and validation of a parent version of the Minneapolis-Manchester Quality of Life Instrument (MMQL-UK (PF)) that could be used in parallel with the child version to assess the HRQL of children with chronic conditions, those in public care and their healthy peers.
Minneapolis-Manchester Quality of Life Instrument (MMQL)
This questionnaire was originally developed in the US for use with child cancer survivors . The original version of the MMQL had three different forms, one for children aged 8–11 (Child form, MMQL-CF), one for 12–18 year olds (Youth Form, MMQL-YF) and one for young people aged 19–25 years. All the original child MMQL forms measured the components of physical functioning, psychological functioning, social functioning, cognitive functioning, body image and outlook on life. Intimate relations was an additional component in the questionnaires for 12–18 and 19–25 year olds. No parent form is available for the original MMQL forms. The anglicised MMQL-UK (CF) version of the questionnaires (based on the 12–18 year age group) was used as the basis for the development of the parent form (MMQL-UK (PF)). This measured the components of physical appearance, school functioning, social functioning, emotional functioning and physical functioning .
PedsQL™ version 4.0 core module
PedsQL™ measurement system is a modular approach to measuring HRQL in children and adolescents and their parents which is rapidly becoming established in the US and Europe [21, 22]. Anglicised versions are also available . It consists of a brief, practical generic core module, which is complemented by a number of condition specific measures. Reliability and validity of the generic core module has been demonstrated . PedsQL™ measures the components of physical functioning, emotional functioning, social functioning and school functioning. Parents or carers were asked to complete this core module as part of the validation of the newly developed parent MMQL-UK.
This study was carried out in the context of a wider study to anglicise and shorten the Manchester-Minneapolis Quality of Life Survey for children (MMQL-UK (CF)). The MMQL-UK (CF) was used as the basis for the development of an adult form (MMQL-UK (PF)).
Before wider administration of the MMQL-UK (PF) could take place, the phrasing of the questions from the child form had to be modified to make them adult oriented. This was done by qualitative methods. An opportunistic sample of 15 parents of school children (age range 10–18) were recruited for interviews from a local school known to one of the researchers (PU) for development of the MMQL-UK (PF). During the interviews parents were asked to comment on the wording and structure of the questionnaire as well as completing a draft parent form. Interviews were carried out either at the home or at Swansea University, depending on the preference of the parent.
The newly developed MMQL-UK (PF) was then compared with the shortened and anglicised version of the MMQL-UK (CF). This paper concentrates specifically on the validation of the MMQL-UK (PF) and comparison with the child (CF) version. The Anglicisation and validation of the MMQL-UK (CF) is reported elsewhere . Although the original MMQL form was developed to measure HRQL in cancer survivors the anglicised MMQL-UK (CF) was developed for use with both healthy and chronic conditions. The MMQL-UK (PF) was therefore developed to be suitable for the same populations (i.e. healthy and chronic conditions).
Inclusion criteria for children and parents entering the study
Children aged 8–18 years with moderate/severe asthma according to definitions given by the British Thoracic Society and their parents
Children aged 8–18 with Type 1 Diabetes Mellitus and their parents
Children aged 8–18 fulfilling diagnostic criteria for Crohn's Disease and Ulcerative Colitis and their parents
Children aged 8–18 years at least six months post treatment for ALL and their parents
Children aged 8–18 years in public care and their carers
Healthy children aged 8–18 years from local schools
Where possible, written information was sent out to the families of children with a chronic health condition one week before a routine outpatient appointment. On attendance at the clinic, a researcher provided a further verbal explanation of the study, took written consent and supervised completion of the questionnaires. Families of children not due in clinic during the data collection period were sent written information along with a reply form on which they could indicate their interest in the study. Telephone contact was made with families responding positively, to provide further verbal feedback about the study. Arrangements were made for families agreeing to take part to complete the questionnaire either in clinic or at home. Children in public care and their carers were provided with verbal and written information when attending paediatric assessments. If families expressed an interest in the study, arrangements were made for a home visit, where the interviewer gained informed consent and questionnaires were completed.
Participants for the control group were recruited from schools in Swansea, Neath, Port Talbot and Bridgend (Wales, UK). The control group were healthy children (and their parents) who were not currently using health care resources for any serious condition. Participants were given a screening questionnaire prior to participation that included a section about health status. Anyone who was identified as having a health problem was excluded from participation in the study. Permission to approach schools was obtained from the Directors of Education in each Local Education Authority, before selecting schools via multi-stage sampling. Information was sent to head teachers of sampled schools, inviting their school to participate. A researcher visited schools expressing an interest, to discuss the project further and arrange for data collection. Written information for parents, parental consent forms and parent questionnaires were supplied for each child to take home. Parents were asked to complete their questionnaires at home and return them to school by a specified date, along with consent for their child to complete the questionnaires. It was emphasised that completion of questionnaires should not involve consultation with the child. For those children that had parental consent, re-explanation and completion of questionnaires followed in class a week later, under the supervision of the researcher.
In both subject and control groups, children with moderate to severe learning difficulties and children and parents for whom English was not their first language were excluded from the study.
The study was approved by the Welsh Multi-centre Research Ethics Committee (MREC). Informed consent was sought from all children (subjects and controls) and their parents or those with parental responsibilities (for children less than 16 years of age), following oral and written explanation of the study.
Data were analysed using the Statistical Package for Social Sciences (SPSS) version 11.4.
Assessing internal consistency
The internal consistency of the MMQL-UK (PF) components were assessed by item-total correlations and Cronbach's alpha . Questions yielding item-total correlations below 0.4 were considered for rejection . Questions were also considered for rejection if more than 75% of individuals gave the same response, because such questions are not sensitive enough to discriminate between different levels of severity . Questions were also considered for exclusion if they were disliked or considered difficult to answer by the parents completing them. Cronbach's alpha for each of the resulting components should exceed 0.7 . Principal components analysis was then performed on the parent content without any restrictions on the data and the structure was compared to the emergent structure from the child form. This was carried out in order to validate the underlying components of the MMQL-UK (PF).
The construct validity of the MMQL-UK (PF) components were assessed by comparing them with the appropriate parent PedsQL™ quality of life scales. If the components were valid measures of HRQL, they would be expected to show significant small to moderate levels of correlation with each of the PedsQL™ scales, with the largest correlations being seen between the PedsQL™ scales measuring physical, social, emotional and school function and the comparable MMQL-UK (PF) components.
The discriminant validity of the MMQL-UK (PF) was assessed by comparison of component scores between parents whose children were being treated and the parents of the control group. Our a priori hypothesis was based on identifying moderate to large differences in effect size between each exemplar and the control group . If the components were valid measures of HRQL, the exemplar groups would be expected to score lower on the MMQL-UK (PF) components than the control group. Independent samples t-tests with Bonferroni corrections were used to compare control and exemplar groups. Differences in component score between the exemplars and control groups were also reported as effect sizes where 0.2–0.49 represented a small difference, 0.5–0.79 represented a moderate difference and greater than 0.8 represented a large difference .
The relationship between the MMQL-UK (CF) and MMQL-UK (PF) was determined using Pearson's correlation. If the two reports measure the same concept, then moderate correlation would be expected between the component scores of the MMQL-UK (CF) and the MMQL-UK (PF).
Following initial completion of the MMQL-UK (PF) by parents of the exemplar group children, they were asked to complete a second 'retest' questionnaire the next time their child visited clinic. This was a maximum of three months after the first assessment. In addition to completing the MMQL-UK (PF), the parents of children were asked to rate whether they thought their child's health had changed (improved, got worse or stayed the same) since the first questionnaire was completed. Those parents reporting no change were included in the reproducibility analysis. Reproducibility was assessed using intra-class correlation co-efficient .
The responsiveness of the MMQL-UK (PF) was assessed by using the scores of the exemplar group parents who reported a change in their child's health. The response ratio (mean change in scores for subjects reporting a change divided by the standard deviation of the subjects reporting no change) was used to quantify the responsiveness . The larger the ratio, the more responsive the instrument.
children and 572 parents completed the MMQL-UK (CF) and MMQL-UK (PF). The internal consistency of the MMQL-UK (PF) was excellent, with all components exceeding the accepted criterion of 0.70 (see Table 2)
Internal consistency of the MMQL-UK (PF) component
Minimum corrected item- component correlation
Maximum corrected item-component correlation
Correlations between the MMQL-UK (PF) and the PedsQL™ proxy-report components
Mean scores (Standard Deviation) for the MMQL-UK (PF) components for the different patient groups and controls
Control (n = 296)
Asthma (n = 37)
Diabetes (n = 70)
Cancer (n = 42)
IBD (n = 56)
Public Care (n = 71)
64.9 (31.8) ES 0.54
67.7 (25.3)* ES 0.50
56.8 (23.6)** ES 0.99
59.5 (25.8)** ES 0.83
69.5 (25.8) ES 0.42
73.1 (26.5) ES 0.11
73.4 (25.7) ES 0.11
45.2 (33.9)** ES 1.02
68.8 (26.0) ES 0.28
52.0 (32.0)** ES 0.83
84.6 (20.3) ES 0.10
87.1 (16.6) ES -0.04
78.3 (16.9)* ES 0.50
83.0 (16.4) ES 0.21
73.5 (25.0)** ES 0.61
63.1 (13.9)* ES = 0.47
62.1 (13.3)** ES = 0.56
60.7 (11.3)** ES = 0.73
59.7 (16.6)** ES = 0.66
67.5 (18.8) ES = 0.10
56.5 (28.0)** ES = 1.31
80.4 (18.0)* ES = 0.37
55.6 (29.5)** ES = 1.30
55.9 (27.8)** ES = 1.28
78.2 (20.7)** ES = 0.46
Reproducibility of the MMQL-UK (PF) components for parents reporting no change in their child's health status (N = 50)
Mean difference (SD) retest-test
95% CI for the difference
-3.65 to 6.45
-4.79 to 4.65
-5.87 to 2.87
-3.24 to 3.93
-3.44 to 3.24
Responsiveness of the MMQL-UK (PF) components for parents reporting an improvement or deterioration in their child's health status
Mean difference for subjects reporting a change (n = 19)
Two tailed significance
SD of the scores of the stable subjects (n = 50)
Correlations between the MMQL-UK (CF) and MMQL-UK (PF)
MMQL-UK (PF) component
MMQL-UK (CF) component
A parent version of the MMQL (MMQL-UK (PF)) was successfully developed based on the anglicised and shortened child version which has been recently validated in the UK (MMQL-UK (CF)). The parent version was developed in parallel with the child version with only minor modifications being made to the wording of the questions.
Good internal reliability was found for the MMQL-UK (PF), with alphas exceeding 0.70 for all the components, thus making them acceptable for group comparisons . Construct validity of the MMQL-UK (PF) was established through moderate correlations with the parent PedsQL™ core module.
Discriminant validity was demonstrated for the MMQL-UK (PF) proxy report with differences being noted in HRQL by parents of healthy children and children with chronic health conditions and carers of children in local authority care. The reproducibility and responsiveness of the MMQL-UK (PF) were indicated by good test-retest results. The relationship between the MMQL-UK (CF) and MMQL-UK (PF) was confirmed by moderate correlations indicating that the two reports measure the same concept.
The availability of a proxy report is important as there may be occasions when a child is either unable or unwilling to complete a HRQL measure. However interpretation of proxy reports should be undertaken with caution as they may not accurately reflect the child's view, particularly for some components. However if they are used in conjunction with a clinical consultation or other objective assessments they could potentially provide useful information on the health of the child .
It should be recognised that both child and proxy ratings have value but the question is to clarify how differences in perception of HRQL arise between the child and the proxy . It has been contested that disagreement is not necessarily undesirable and multiple viewpoints can be valid and informative . Caregivers may recognize functional limitations that patients are unaware of or deny. Arguably, assessments of HRQL that are used to inform decision making in health care based on community-based preferences need not be restricted to the patient perspective .
It is recommended that parent proxy reports be available for child HRQL measures, a condition that the PedsQL™ also fulfils. The availability of proxy-reports in addition to child reports may be more desirable than reports from the child alone. In medical consultations, the clinicians often look to the parents for guidance regarding medical decision making in relation to their children . The parent view of their child's HRQL can be informative and provide an alternative viewpoint .
Further studies are needed to determine the accuracy of the MMQL-UK (PF) proxy reports compared with the MMQL-UK (CF) child reports in other conditions and different age groups of children. The usefulness of the MMQL-UK (PF) in assessing longitudinal outcomes of children also warrants further attention.
This study established the reliability and validity of a new MMQL proxy report (MMQL-UK (PF)). The MMQL-UK (PF) showed good correlations with the child form (MMQL-UK (CF)) in healthy children, those in public care and those suffering from chronic conditions.
Health related quality of life
Minneapolis-Manchester Quality of Life Instrument
Inflammatory Bowel Disease
Bone Marrow Transplant
Acute Lymphoblastic Leukaemia
Multi-centre Research Ethics Committee
Statistical Package for Social Sciences
We would like to thank the Welsh Office of Research and Development (WORD) for funding the research. We would like to thank the authors of the US MMQL (Smith Bhati and Robert L. Kane) for giving us permission to use the MMQL. We would also like to thank all the collaborators in local clinics, Social Services, Local Education Authorities and participating schools without whom this research would not have been possible.
- Ronen GM, Streiner DL, Rosenbaum P: Health-related quality of life in childhhod epilepsy: Moving beyond 'seizure control with minimal adverse effects'. Health Qual Life Outcomes 2003, 1: 36. 10.1186/1477-7525-1-36PubMed CentralView ArticlePubMedGoogle Scholar
- Matza LS, Swensen AR, Flood EM, Secnik K, Kline Leidy N: Assessment of health-related quality of life in children: A review of conceptual, methodological, and regulatory issues. Value Health 2004, 7(1):79–92. 10.1111/j.1524-4733.2004.71273.xView ArticlePubMedGoogle Scholar
- Connolly MA, Johnson JA: Measuring quality of life in paediatric patients. Pharmacoeconomics 1999, 16(6):605–625. 10.2165/00019053-199916060-00002View ArticlePubMedGoogle Scholar
- Marra CA, Levine M, McKerrow R, Carleton BC: Overview of health-related quality-of-life measures for pediatric patients: application in the assessment of pharmacotherapeutic and pharmacoeconomic outcomes. Pharmacotherapy 1996, 16(5):879–888.PubMedGoogle Scholar
- Mulhern RK, Horowitz ME, Ochs J, Freidman AG, Armstrong FD, Copeland D, Kun LE: Assessment of quality of life among pediatric patients with cancer. Psychol Assess 1989, 1: 130–138. 10.1037/1040-35126.96.36.199View ArticleGoogle Scholar
- Juniper EF, Guyatt GH, Feeny DH, Griffith LE, Ferrie PJ: Minimun skills required by children to complete health-related quality of life instruments for asthma: comparison of measurement properties. Eur Respir J 1997, 10: 2285–2294. 10.1183/09031936.97.10102285View ArticlePubMedGoogle Scholar
- Guyatt GH, Juniper EF, Feeny DH, Griffith LE: Children and adult perceptions of childhood asthma. Pediatrics 1997, 99: 165–168. 10.1542/peds.99.2.165View ArticlePubMedGoogle Scholar
- Eiser C, Morse R: A review of measures of quality of life for children with chronic illness. Arch Dis Child 2001, 84: 205–211. 10.1136/adc.84.3.205PubMed CentralView ArticlePubMedGoogle Scholar
- Parsons SK, Barlow SE, Levy SL, Supran SE, Kaplan SH: Health-related quality of life in pediatric bone marrow transplant survivors: according to whom? In J Cancer Suppl 1999, 12: 46–51. Publisher Full Text 10.1002/(SICI)1097-0215(1999)83:12+<46::AID-IJC9>3.0.CO;2-CView ArticleGoogle Scholar
- Jokovic A, Locker D, Guyatt G: How well do parents know their children? Implications for proxy reporting of child health-related quality of life. Qual Life Res 2004, 13: 1297–1307. 10.1023/B:QURE.0000037480.65972.ebView ArticlePubMedGoogle Scholar
- Sprangers MA: The role of health care providers and significant others in evaluating the quality of life of patients with chronic disease: a review. J Clin Epidemiol 1992, 45(7):743–760. 10.1016/0895-4356(92)90052-OView ArticlePubMedGoogle Scholar
- Sawyer MG, Antoniou G, Toogood I, Rice M: A comparison of parent and adolescent reports describing the health-related quality of life of adolescents treated for cancer. In J Cancer 1999, Supplement 12: 39–45. Publisher Full Text 10.1002/(SICI)1097-0215(1999)83:12+<39::AID-IJC8>3.0.CO;2-7Google Scholar
- Upton P, Eiser C, Cheung I, Hutchings HA, Jenney M, Maddocks A, Russell IT, Williams JG: Measurement properties of the UK-English version of the Pediatric quality of life inventoryTM 4.0 (PedsQLTM) generic core scales. Health Qual Life Outcomes 2005., 3(22):
- Eiser C: Children's quality of life measures. Arch Dis Child 1997, 77: 350–354.PubMed CentralView ArticlePubMedGoogle Scholar
- le Coq EM, Boeke AJP, Bezemer PD, Colland VT, van Eijk JTM: Which source should we use to measure quality of life in chidlren with asthma: the children themselves or their parents? Qual Life Res 2000, 9: 625–636. 10.1023/A:1008977200176View ArticlePubMedGoogle Scholar
- Ronen GM, Streiner DL, Rosenbaum P: Health-related quality of life in children with epilepsy: Development and validation of self-report and parent proxy measures. Epilepsia 2003, 44(4):598–612. 10.1046/j.1528-1157.2003.46302.xView ArticlePubMedGoogle Scholar
- Eiser C: Children with cancer: quality of life. London , Lawrence Erlbaum Associates; 2004.Google Scholar
- Drotar DE: Measuring health related quality of life in children and adolescents: Implications for research and practice. London , Lawrence Erlbaum Associates; 1998.Google Scholar
- Bhatia S, Jenney ME, Bogue MK, Rockwood TH, Feusner JH, Friedman DL, Robison LL, Kane RL: The Minneapolis-Manchester Quality of Life instrument: reliability and validity of the Adolescent Form. J Clin Oncol 2002, 20(24):4692–4698. 10.1200/JCO.2002.05.103View ArticlePubMedGoogle Scholar
- Hutchings HA, Upton P, Cheung WY, Maddocks A, Eiser C, Williams JG, Russell IT, Jackson S, Jenney MEM: Adaptation of the Manchester-Minneapolis Quality of Life Instrument for use in the UK population. Arch Dis Child 2007, 92: 855–860. 10.1136/adc.2006.098947PubMed CentralView ArticlePubMedGoogle Scholar
- Varni JW, Seid M, Rode CA: The PedsQLTM: Measurement model for the pediatric quality of life inventory. Med Care 1999, 37(2):126–139. 10.1097/00005650-199902000-00003View ArticlePubMedGoogle Scholar
- Varni JW, Seid M, Kurtin PS: PedsQLTM 4.0: Reliability and validity of the pediatric quality of life inventoryTM version 4.0 generic core scales in healthy and patient population. Med Care 2001, 39(8):800–812. 10.1097/00005650-200108000-00006View ArticlePubMedGoogle Scholar
- Cronbach LJ: Coefficient alpha and the internal structure of tests. Psychometrika 1951, 16: 297–334. 10.1007/BF02310555View ArticleGoogle Scholar
- Streiner GL, Norman RD: Health measurement scales. A practical guide to their development and use. Oxford , Oxford University Press; 1995.Google Scholar
- Nunnally JC, Bernstein IR: Psychometric Theory. 3rd edition. New York , McGraw-Hill; 1994.Google Scholar
- Cohen J: Statistical power analysis for the behavioural sciences. 2nd edition. Hillsdale, New Jersey , Lawrence Erlbaum Associates, Inc; 1988.Google Scholar
- Deyo RA, Diehr P, Patrick DL: Reproducibility and responsiveness of health status measures. Statistics and strategies for evaluation. Control Clin Trials 1991, 12: 142S- 158S. 10.1016/S0197-2456(05)80019-4View ArticlePubMedGoogle Scholar
- Feeny D, Furlong W, Barr RD: Multiattribute approach to the assessment of health-related quality of life: health utilities index. Medical and Pediatric Oncology 1998, (Suppl 1):54–59. Publisher Full Text 10.1002/(SICI)1096-911X(1998)30:1+<54::AID-MPO8>3.0.CO;2-Z
- Pickard AS, Johnson JA, Feeny DH, Shuaib A, Carriere KC, Nasser AM: Agreement between patient and proxy assessments of health-related quality of life after stroke using the EQ-5D and health utilities index. Stroke 2004, 35: 607–612. 10.1161/01.STR.0000110984.91157.BDView ArticlePubMedGoogle Scholar
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