The aim of this study was to study the role of menopausal status and physical activity on quality of life.
A total of 1,165 Finnish women aged 45-64 years from a national representative population-based study were followed up for 8 years. Study participants completed the Health 2000 study questionnaire and follow-up questionnaire in 2008. Ordinal logistic regression analysis was used to measure the effect of menopausal status on global quality of life (QoL). Other variables included in the analyses were age, education, change of physical activity as assessed with metabolic equivalents, change of weight and hormone therapy (HRT) use.
Peri- and postmenopausal women increased their physical activity (28% and 27%) during the eight-year follow up period slightly more often than premenopausal (18%) women (p = 0.070). Menopausal status was not significantly correlated with change of QoL. QoL of the most highly educated women was more likely to improve than among the less educated (eb = 1.28, 95%CI 1.08 to 1.51 p = 0.002). Women whose physical activity increased or remained stable had greater chances for improved QoL than women whose physical activity decreased (eb = 1.49, 95%CI 1.23 p < 0.001 to 1.80, eb = 1.46, 95%CI 1.24 to 1.73 p < 0.001 respectively). Women whose weight remained stable during follow-up also improved their QoL compared to women who gained weight (eb = 1.26, 95%CI 1.07 to 1.50 p > 0.01). Women who had never used HRT had 1.26 greater odds for improved QoL (95%CI 1.02 to 1.56 p = < 0.05).
Improvement of global QoL is correlated with stable or increased physical activity, stable weight and high education, but not with change in menopausal status.
Menopausephysical activitylongitudinal study
Women experience menopause between 40 and 58 years of age, the median age being 51 years . Menopause is also a time of life with many symptoms and poor health status, which affect quality of life [2, 3]. Menopause is also associated with a number of physical, psychological and social changes . Many studies have found that the menopause is associated with deteriorating quality of life (QoL) . Menopause may be accompanied by health problems with decreasing estrogen levels with symptoms such as hot flushes, night sweats and vaginal dryness. In a number of studies menopausal symptoms have been reported to be associated with quality of life indicators . On the other hand there are also study results indicating that well-being is not associated with menopausal status per se but is associated with current health status .
Physical activity has been shown also to enhance quality of life among menopausal women [8, 9] and some studies suggest that physical activity is associated with a decrease of hot flushes [10, 11]. The effect of physical activity in decreasing hot flushes has been explained by β-endorphin theory. It is known that increase of hypothalamic β-endorphin production may stabilize thermoregulation known to be disturbed during menopausal hot flushes. Physical activity may help in controlling body weight, which is associated with more frequent vasomotor symptom reporting [10, 13]. It has been shown that weight gain in midlife is not specifically related to menopause but to aging [14–16], and gaining weight may impair quality of life [16, 17]. The question whether menopausal transition could be considered as 'window of opportunity', i.e. whether there is any lifestyle modification during menopausal transition, is left open.
Our aim was to study the role of physical activity and menopausal status in change in quality of life among menopausal women.
The baseline data come from a health examination study entitled Health 2000. This was carried out in Finland between 2000 and 2001 and has been described in detail elsewhere [18, 19]. A nationally representative two-stage stratified cluster sample was drawn of adults aged 30 and over and living in mainland Finland. A total of 7,419 subjects (93% of the 7,977 subjects originally drawn from the population register) participated in one or more phases of the study. Data collection included an extensive home interview, three self-administered questionnaires and a clinical examination by a physician. The response rate for the home interview was 87.6% and for the first self-administered questionnaire 84.4% among the whole study population. The response rate among women aged 45-64 years at baseline was 86.6%.
In 2008 all respondents who were 37-56 years old in 2000 (45-64 years old in 2008) were sent a mailed questionnaire. After three reminders the overall response rate was 82.2% (n = 1,239). Of the respondents, 1 239 women who had responded both to the home interview and to the self-administered questionnaire were included into this study (n = 1,165). In the 8-year follow-up study most of the questions and indicators were similar to those in the baseline Health 2000 study (menopausal status, symptoms list, quality of life, general health, coping at work).
Menopausal status and transition category
Women with a normal, regular menstrual cycle during the past 12 months were classified as premenopausal, women with an irregular menstrual cycle during the past 12 months as perimenopausal, and women whose last menstrual cycle had occurred more than 12 months ago as postmenopausal regardless whether HRT was used or not.
Three menopause transition categories were defined as: 1) premenopause at both baseline and follow-up (pre-pre), 2) transition from premenopause to peri- or postmenopause (pre-peri/post) and 3) perimenopause or postmenopause baseline and follow-up from perimenopause to postmenopause (peri-peri/post, post-post).
Physical activity was measured by MET (Metabolic Equivalent) hours per week (continuous variable) in years 2000 and 2008. MET variables were categorized as less than 21 MET hours per week = low activity, 21-42 MET hours per week = moderate activity and more than 42 MET hours per week = high activity.
Change in physical activity was defined as MET per week in year 2000 minus MET per week in year 2008 and coded as decreased when the change was -1, -2 or -3, increased when the change was 1 or 2 and when there was no change it was 0.
Physical activity variable MET per week was measured in the 2000 questionnaire with the following questions: 1) How much time overall do you spend on heavy physical activity on those days when you exercise for at least 10 minutes?", 2) How much time overall do you spend on moderate physical activity on those days when you exercise for at least 10 minutes?", 3. How much time overall do you spend on brisk walking on those days you walk for at least 10 minutes?". In 2008 questionnaire physical activity variable MET per week was elicited with the questions: "How much time per week do you spend on" a) brisk walking and rapid movement from one place to another or for recreation, pleasure or fitness? b) do something that demands moderate physical effort, for example cycling, vacuuming, gardening or some other function that cause some breathlessness and increasing heart rate (do not count walking in this group)? c) do something that demands hard physical effort, for example, running, aerobics, heavy gardening or some other activity that causes heavy perspiration and rapid increase in heart rate. Response alternatives were 1 = not at all, 2 = less than 1/2 hour per week, 3 = one hour per week, 4 = 2-3 hours per week, 5 = 4 hours or more per week.
MET variable was developed for comparison of year 2000 and 2008 data concerning physical activity. First we calculated MET from year 2000 data: how long time did responders spend in physical activity (heavy, moderate and light) during each day (in minutes). Minutes were then converted to hours and multiplied by 7 (one week time). Thereafter physical activity was divided to five categories which were: 1 = not at all, 2 = less than 1/2 hour per week, 3 = one hour per week, 4 = 2-3 hours per week, 5 = 4 hours or more per week. Year 2008 data was already in this category format. MET variable was then calculated by multiplying all categories with specified coefficient to make all physical activity with different intensities comparable. Coefficients for different physical activities are shown in table 1 (table 1). Thereafter we calculated MET hours and divided them as 1) less than 21 MET hours per week = low activity, 2) 21-42 MET hours per week = moderate activity and 3) more than 42 MET hours per week = high activity .
Coefficients for physical exercise
Light physical exercise
Moderate physical exercise
Heavy physical exercise
1 = not at all
2 = less than 1/2 hour per week
3 = one hour per week
4 = 2-3 hours per week
5 = 4 hours or more per week
Weight was measured in kilograms in both 2000 and 2008 surveys. Body mass index was defined as weight (kg)/height squared (m2). Change in (kg) weight was defined as weight in 2000 minus weight in 2008. Stable weight was defined as weight in 2008 between -5.0 and 5.0 kg of weight in 2000. Women who lost or gained more than 5.0 kg were classified respectively as weight losers and weight gainers.
Quality of Life
Quality of life (QoL) was measured on the Ladder of Life scale modified by Andrew and Withey. Respondents were asked to evaluate their QoL during the previous month. The scale was from 0 to 10 with 0 meaning worst possible quality of life and 10 meaning best possible quality of life. Responses were categorized as 0-4 (poor), 5-7 (moderate), 8 (good), 9-10 (excellent) . Change in quality of life was defined as QoL in 2000 minus QoL of life in 2008 resulting in the categories -3, -2, -1 defined as deteriorated QoL, 0 defined as no change and 1 or 2 defined as improved QoL.
Hormone therapy (HRT)
Hormone therapy (HRT) use was defined at baseline by last month of using HRT and at 8-year follow-up during year 2008 use during last six months. Categories in both baseline and follow-up surveys were similar- current, previous and never users. Current users were women who used HRT when they answering the questionnaire. Previous users had used HRT before but not now. Never users were those who did not report any use of HRT at baseline or follow-up, or the period between these survey timings.
Baseline and follow-up characteristics were tabulated (mean and standard deviations) or as proportions and percentages. Differences between baseline and follow-up values were evaluated using McNemar's test. Changes in physical activity in different menopausal groups were tabulated with proportions and percentages. Differences between menopausal groups were tested using chi square test.
The effect of menopausal status and change in physical activity on quality of life changes was tested with ordinal regression analyses. The models included baseline QoL, age, education (primary, secondary and tertiary), weight change and use of hormone replacement therapy (HRT). We used ordinal logistic regression since the dependent variable (quality of life) was not normally distributed and was ordinal scale (-2 and -1 = declined, 0 = stable, 1 and 2 = improved) and thus did not meet the criteria for linear regression analyses. Quality of life change was used as dependent variable, menopausal status and change in physical activity (MET hours/week) as confounding factors (QoL at baseline, age, education, weight change as independent variables).
We used ordinal regression although testing parallel lines assumption showed that the general model did not greatly improve the fit. We also conducted a multinomial regression analysis because of this absence of assumptions and obtained the same results as in the ordinal regression. Ordinal regression is easier to interpret than multinomial regression analysis. Results of the ordinal model are interpreted in such a way that larger coefficients (> 1) indicate an association with larger scores, lower coefficients (< 1) association with lower scores, respectively.
The full model was adjusted for age, education, menopause status, change in physical activity and change in weight. All analyses were performed using the Statistical Package for the Social Sciences, version 15.0 statistical packages.
At baseline the mean age of the study sample was 47.0 years and in 2008 it was 56.0 years. The proportion of women reporting at least moderate physical activity (at least 21-42 MET hours) was higher at the follow-up as compared to baseline (p > 0.001). The proportion of women with overweight (33% to 34%) or obesity (24% to 23%) was stable over time. At baseline over half of the women (67%) were premenopausal and in 2008 only a fifth of women (19.9%). Among all women 38% reported excellent quality of life at baseline, but only 26% at 2008 follow-up. Proportion of women using HRT was higher at 2008 as compared to year 2000 (Table 2)
Baseline characteristics of the cohort study: age, socioeconomic background and lifestyle (N = 1165)
Quality of life1)
Hormone replacement therapy use5)6)
1) missing 12
2) MET = metabolic equivalent hours, missing 47
3) missing 20
4) missing 14
5) missing 12
6) 2000: last month 2008:last six month
Women whose menopausal status changed from premenopause to perimenopause or postmenopause increased their physical activity (28% and 27%) during the 8-year follow-up more often than did premenopausal women (18%) and the differences were close to be significant (p = 0.070) (Table 3). There were no significant differences between the three groups in changes in QoL (p = 0.38) or weight change (p = 0.38). However, proportion of women whose quality of life deteriorated was higher among women in menopausal transition (41.5%) than compared to premenopausal women (34.5%) or postmenopausal women (34.9%). Proportion of weight gainers was highest among premenopausal women as compared to other groups (Table 3).
Change of global QoL, physical activity and weight during 8-year follow-up by menopausal group
(n = 229)
(n = 535)
(n = 762)
Quality of life1)
Losers < 5 kg
Stable ± 5 kg
Gainers > 5 kg
1) missing 26
2) missing 34
3) missing 29
* tested with chi square test
a) premenopause at both baseline and follow up
b) transition from premenopause to peri- or postmenopause
c) perimenopause or postmenopause both at baseline and follow-up; from perimenopause at baseline to postmenopause at follow-up
QoL of the most highly educated women had improved more than QoL of the least educated women (Table 4). Women whose physical activity increased or remained stable had improved QoL more often than women whose physical activity diminished. Women whose weight remained stable were more likely to have better QoL than women who gained weight during follow-up. Women who had never used HRT had better QoL than women who were current HRT. Women who were current HRT users had more deterioration in quality of life than women who had never used HRT (results not shown in the tables).
Ordinal regression analysis for change in quality of life (dependent variable), results from a model including all covariates shown in the table
0.99 to 1.30
Menopausal transition status
0.77 o 1.14
0.70 to 1.11
0.85 to 1.21
1.08 to 1.51
QoL at baseline
8.38 to 24.00
4.91 to 7.19
1.67 to 2.28
Physical activity change (MET/week)
1.24 to 1.73
1.23 to 1.80
1.07 to 1.50
0.94 to 1.53
HRT Use in baseline
0.73 to 1.18
1.02 to 1.56
Interpretation of results: if eβ > 1, the odds of higher QoL are greater, whereas when eβ < 1 low QoL is more probable.
*p < 0.05
**p < 0.01
***p < 0.001
a) premenopause at both baseline and follow up
b) transition from premenopause to peri- or postmenopause
c) perimenopause or postmenopause both at baseline and follow-up; from perimenopause at baseline to postmenopause at follow-up
The aim of this study was to assess the relationships between changes in quality of life, menopausal status and physical activity. Change in global quality of life is more associated with change in physical activity than change in menopausal status. Similar findings have been reported in other studies . However, women whose physical activity or weight remained the same, physical activity increased or women who were the most highly educated, had improved QoL over time. Mishra et al.  in their longitudinal study with 2 years of follow-up found that certain domains of QoL decline with aging and physical aspects of general health and well-being measured by SF-36 scale declined during the menopausal transition. Women who were perimenopausal for at least a year reported greater decline in their physical health and psychosomatic domains than did premenopausal women .
Peri- and postmenopausal women increased their physical activity during the 8-year follow-up compared to premenopausal women Physical activity has been reported to decrease with age , but in our study it seems that women in menopausal transition changed their behaviour in another direction. Increased motivation for lifestyle modification during menopausal transition could explain this increasing physical activity.
Elavsky et al.  in their longitudinal study found that physical activity improves physical self-worth and positive affect and that the improvements in affect lead to improvements in QoL. In our study those women who decreased their physical activity had deterioration in QoL than did women whose physical activity remained stable. Women who increased their physical activity improved their QoL. In the study by Elavsky et al.  increase in physical activity mediated positive affect and therefore had an effect on QoL. Some other studies claim that physical activity alleviates menopausal symptoms (hot flushes) and so improves QoL [11, 27]. It is hypothesized that endorphin concentration in the hypothalamus decreases and oestrogen production declines, facilitating the release of norepinephrine and serotonin. Exercise may have similar ameliorating effects on vasomotor symptoms by increasing the presence of hypothalamic and peripheral β-endorphin production. Through these mechanisms, exercise may help to stabilize the thermoregulatory centre and diminish the risk of hot flushes . The relationship between physical activity and QoL during the menopause is complex and may involve a number of alternative mechanisms, physiological or psychological or both.
Women who gained weight were more likely to report deterioration in QoL. This is consistent with other studies [23, 16]. The eight-year follow-up study by Dennerstein et al. found that increase of body mass index was associated with decline in self-rated health. Whether this is because of their knowledge of the relationship between body fatness and chronic disease or whether it reflects a problem with body image is unknown. In the study by Sammel et al.  the major predictors of weight gain among menopausal women were quality of life and other psychological factors including depressed mood and anxiety. One might speculate some causality between these factors; did weight gain lead to decline in QoL or did poorer QoL lead to weight gain? The Study of Women's Health Across the Nation (SWAN) , which is a multiethnic cohort study, found that women who had gained weight during the study period reported more vasomotor symptoms (hot flushes) than women whose weight remained stable and hence also poorer QoL.
However, the question of association between obesity and vasomotor symptoms is contradictory. Obese postmenopausal women have an increased peripheral conversion of androstenedione to estrone in adipose tissue compared to normal weight women, might be associated with fewer hot flushes in overweight women. On the other hand, lean women have more hot flushes at the time of menopause  and they have been shown to use HRT more frequently , although opposite results also exist . Stadberg et al  found that a higher BMI was correlated with a higher climacteric symptom score. They thought that possible reason maybe that overweight women sweat more often because of their extra weight load and obesity is also associated with less exercise and poorer general health. Overweight could also be viewed as a lifestyle factor with less concern about health and lower self-esteem .
It was a limitation of our study that information on QoL was elicited only in one straight question, not different dimensions of quality of life, as for example the SF-36 Health Survey questionnaire. In SF-36 scale there are 36 items assessing eight dimensions of quality of life. The global QoL scale is self-anchoring because ratings are made relative to each person's conception of her best or worst QoL. Nor could we use symptoms questions in a longitudinal perspective because the questions in the baseline and follow-up studies were different and thus not comparable.
The main strengths of our study were the size and the fact that it was longitudinal study on Finnish female population with a high response rate. The longitudinal nature of the study meant that it was possible to thoroughly investigate change in physical activity and other related factors during the menopausal transition between two time points.
Menopausal transition was not significantly correlated with change in global QoL during 8-year follow-up. However, women who increased their physical activity, had stable weight or were most highly educated had improved QoL. Our study pinpoints the importance of physical activity increase during menopausal transition and also supports the hypothesis that menopause may be a window of opportunity, since it may induce lifestyle modification.
Academy of Finland, Ministry of Education, Juho Vainio Foundation and Competitive Funding from Pirkanmaa Hospital District (grant to Dr Luoto) have supported financially the project.
School of Health Sciences, University of Tampere
Service system department, National Institute for Welfare and Health
UKK Institute for Health Promotion
University of Southern Denmark
Department of children, young people and families, National Institute for Welfare and Health
Zapantis G, Santoro N: The menopausal transition: characteristics and management. Best Practice and Research Clinical Endocrinology Metabolism. 2003, 17: 33–52.
Utian W: Psychosocial and socioeconomic burden of vasomotor symptoms in menopause: A comprehensive review. Health Qual Life Outcomes 2005., 5: 3:47
McVeigh C: Perimenopause: more than hot flushes and night sweats for some Australian women. J Obstet Gynecol Neonatal Nurs 2005, 34: 21–27. 10.1177/0884217504272801View ArticlePubMed
Kumari M, Stafford M, Marmot M: The menopausal transition was associated in a prospective study with decreased health functioning in women who report menopausal symptoms. Journal of Clinical Epidemiology 2005, 58: 719–727. 10.1016/j.jclinepi.2004.09.016View ArticlePubMed
Blumel JE, Castelo-Branco C, Binfa L, Gramegna G, Tacla X, Aracena B, Cumsille MA, Sanjuan A: Quality of life after the menopause: a population study. Maturitas 2000, 34: 17–23. 10.1016/S0378-5122(99)00081-XView ArticlePubMed
Schneider HPG: The quality of life in the post-menopausal woman. Best Pract Res Clin Obstet Gynaecol 2002, 16: 395–409. 10.1053/beog.2002.0289View ArticlePubMed
Dennerstein L: Well-being, symptoms and the menopausal transition. Maturitas 1996, 23: 147–157. 10.1016/0378-5122(95)00970-1View ArticlePubMed
Elavsky S: Physical activity, menopause and quality of life: The role of affect and self-worth across time. Menopause 2009, 16: 265–271. 10.1097/gme.0b013e31818c0284PubMed CentralView ArticlePubMed
Courneya KS, Tamburrini AL, Woolcott CG, McNeely ML, Karvinen K, Campbell KL, McTierman A, Friedenreich CM: The Alberta physical activity and breast cancer prevention trial: quality of life outcomes. Prev Med 2011, 52: 26–32. 10.1016/j.ypmed.2010.10.014View ArticlePubMed
Gold EB, Sternfeld B, Kelsey JL, Brown C, Mouton C, Reame N, Salamone L, Stellato R: Relation of demographic and lifestyle factors to symptoms in a? multi-racial/ethnic population of women 40–55 years of age. Am J Epidemiol 2000, 152: 463–73. 10.1093/aje/152.5.463View ArticlePubMed
Ivarsson T, Spetz A-C, Hammar M: Physical exercise and vasomotor symptoms in postmenopausal women. Maturitas 1998, 29: 139–146. 10.1016/S0378-5122(98)00004-8View ArticlePubMed
Hammar M, Berg G, Lindgren R: Does physical exercise influence the frequency of postmenopausal hot flushes? Acta Obst Gyn Scand 1990, 69: 409–12. 10.3109/00016349009013303View ArticlePubMed
Thurston RC, Sowers MF, Sternfeld B, Gold EB, Bromberger J, Chang Y, Joffe H, Crandall CJ, Waetjen LE, Matthews KA: Gains in body fat and vasomotor symptom reporting over menopausal transition. The American Journal of Medicine 2009, 170: 766–774.
Wing RR, Matthews KA, Kuller LH, Meilahn EN, Plantiga PL: Weight gain at the time of menopause. Arch Intern Med 1991, 151: 97–102. 10.1001/archinte.1991.00400010111016View ArticlePubMed
Wang Q, Hassanger C, Ravn P, Wang S, Christiansen C: Total and regional body composition changes in early menopausal women; age related or menopause? Am J Clin Nutr 1994, 60: 843–848.PubMed
Sammel MD, Grisso JA, Freeman EW, Hollander L, Liu L, Liu S, Nelson DB, Battistini M: Weight gain among women in the late reproductive years. Family practice 2003, 20: 401–411. 10.1093/fampra/cmg411View ArticlePubMed
Matthews KA, Bromberger JT: Does the menopausal transition affect health-related quality of life? The American Journal of Medicine 2005, 118: 25S-36S.View Article
Aromaa A, Koskinen S (Eds): Health and functional capacity in Finland. Baseline results of the Health 2000 Health examination survey Publications of the National Public Health Institute B12/2004, Helsinki;
Heistaro S (Ed): Methodology Report In Health 2000 Survey. Publications of the National Public Health Institute B26/2008, Helsinki;
Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, O'Brien WL, Bassett DR Jr, Schmitz KH, Emplaincourt PO, Jacobs DR Jr, Leon AS: Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 2000, 32: 498–504. 10.1097/00005768-200009001-00009View Article
Andrews FM, Withey SB: Social indicators of well-being: Americans'perceptions of life quality. New York: Plenum; 1976.View Article
Avis NE, Assmann SF, Kravitz HM, Ganz PA, Ory M: Quality of life in diverse groups of midlife women: Assessing the influence of menopause, health status and psychosocial and demographic factors. Quality of Life Research 2004, 13: 933–946.View ArticlePubMed
Dennerstein L, Dudley EC, Guthrie JR: Predictors of declining self-rated health during the transition to menopause. Journal of Psychosomatic Research 2003, 54: 147–153. 10.1016/S0022-3999(02)00415-4View ArticlePubMed
Mishra GD, Brown WJ, Dobson AJ: Physical and mental health: Changes during menopause transition. Quality of life Research 2003, 12: 405–412. Utian 2005 10.1023/A:1023421128141View ArticlePubMed
Pedersen P, Kjøller M, Ekholm O, Grønbæk M, Curtis T: Readiness to change level of physical activity in leisure time among physically inactive Danish adults. Scand J Public Health 2009, 37: 785–792. 10.1177/1403494809344443View ArticlePubMed
Elavsky S: Physical activity, menopause, and quality of life: The role of affect and self-worth across time. Menopause 2009, 16: 265–271. 10.1097/gme.0b013e31818c0284PubMed CentralView ArticlePubMed
Dennerstein L, Lehert P, Guthrie JR, Burger HG: Modeling women's health during the menopausal transition: a longitudinal analysis. Menopause 2007, 14: 53–62. 10.1097/01.gme.0000229574.67376.baView ArticlePubMed
Reid RL, Hoff JD, Yen SS, Lee CH: Effects of exogenous beta h-endorphin on pituitary hormone secretion and its disappearance rate in normal human subjects. J Clin Endocrinol Metab 1981, 52: 1179–83. 10.1210/jcem-52-6-1179View ArticlePubMed
Thurston RC, Sowers MF, Chang Y, Sternfeld B, Gold EB, Johnston JM, Matthews KA: Adiposity and reporting of vasomotor symptoms among midlife women. The study of women's health across the nation. Am J of Epidemiol 2008, 167: 78–85.View Article
Erlik Y, Meldrum DR, Judd HL: Estrogen levels in postmenopausal women with hot flushes. Obstet Gynecol 1982, 59: 403–7.PubMed
Jalava-Broman J, Mäkinen J, Ojanlatva A, Jokinen K, Sillanmäki L, Rautava P: Tratment of climacteric symptoms in Finland prior to the controversial reports on hormone therapy. Acta Obstetrica et Gynecologica 2008, 87: 682–6. 10.1080/00016340802146920View Article
Den Tonkelaar I, Seidell J, van Noord P: Obesity and fat distribution in relation to hot flushes in Dutch women from the DOM-project. Maturitas 1996, 23: 301–5. 10.1016/0378-5122(95)00990-6View ArticlePubMed
Stadberg E, Mattson L-Å, Milsom I: Factors associated with climacteric symptoms and the use of hormone replacement therapy. Acta Obstet Gynecol Scand 2000, 79: 286–92. 10.1080/j.1600-0412.2000.079004286.xView ArticlePubMed
Kirchengast S: Realtions between antropomethric characteristic and degree of severity of climacteric syndrome in Australian women. Maturitas 1993, 17: 167–80. 10.1016/0378-5122(93)90044-IView ArticlePubMed
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.